{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:29Z","timestamp":1790724509230,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National High Level Hospital","award":["2022-PUMCH-B-074"],"award-info":[{"award-number":["2022-PUMCH-B-074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To establish the epidemiology cut-off (ECOFF) values of eravacycline against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii and Staphylococcus aureus, from a multi-centre study in China.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected 2500 clinical isolates from five hospitals in China from 2017 to 2020. The MICs of eravacycline were determined using broth microdilution. The ECOFF values of eravacycline against the five species commonly causing cIAIs were calculated using visual estimation and ECOFFinder following the EUCAST guideline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The MICs of eravacycline against all the strains were in the range of 0.004\u201316 mg\/L. The ECOFF values of eravacycline were 0.5 mg\/L for E. coli, 2 mg\/L for K. pneumonia and E. cloacae, and 0.25 mg\/L for A. baumannii and S. aureus, consistent with the newest EUCAST publication of eravacycline ECOFF values for the populations. No discrepancy was found between the visually estimated and 99.00% ECOFF values calculated using ECOFFinder.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The determined ECOFF values of eravacycline against the five species can assist in distinguishing wild-type from non-wild-type strains. Given its promising activity, eravacycline may represent a member of the tetracycline class in treating cIAIs caused by commonly encountered Gram-negative and Gram-positive pathogens.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae220","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T10:20:45Z","timestamp":1721125245000},"page":"2246-2250","source":"Crossref","is-referenced-by-count":15,"title":["Establishment of epidemiological cut-off values for eravacycline, against <i>Escherichia coli<\/i>, <i>Klebsiella pneumoniae<\/i>, <i>Enterobacter cloacae<\/i>, <i>Acinetobacter baumannii<\/i> and <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"79","author":[{"given":"Ran","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Lian","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-3900","authenticated-orcid":false,"given":"Qi-Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Song","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Peking University First Hospital , Beijing 100191 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Peking University First Hospital , Beijing 100191 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Pin","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, and Key Laboratory of Clinical Pharmacology of Antibiotics , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University, and Key Laboratory of Clinical Pharmacology of Antibiotics , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Yue","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Everest Medicines (China) Co., Ltd. , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China"},{"name":"Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"2024090302262056900_dkae220-B1","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.2147\/IDR.S182180","article-title":"A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese antimicrobial resistance surveillance of nosocomial infections (CARES) 2007\u20132016","volume":"11","author":"Zhang","year":"2018","journal-title":"Infect Drug Resist"},{"key":"2024090302262056900_dkae220-B2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/sur.2013.181","article-title":"Bacteriology of spontaneous intra-abdominal abscess in patients with Crohn disease in China: risk of extended-spectrum beta-lactamase-producing bacteria","volume":"16","author":"Li","year":"2015","journal-title":"Surg Infect (Larchmt)"},{"key":"2024090302262056900_dkae220-B3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/sur.2014.148","article-title":"Epidemiology and microbiology of secondary peritonitis caused by viscus perforation: a single-center retrospective study","volume":"16","author":"Jang","year":"2015","journal-title":"Surg Infect (Larchmt)"},{"key":"2024090302262056900_dkae220-B4","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/cc8877","article-title":"Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis","volume":"14","author":"Augustin","year":"2010","journal-title":"Crit Care"},{"key":"2024090302262056900_dkae220-B5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/QCO.0b013e32835635cb","article-title":"Changing bacteriology of abdominal and surgical sepsis","volume":"25","author":"Chen","year":"2012","journal-title":"Curr Opin Infect Dis"},{"key":"2024090302262056900_dkae220-B6","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing\u2014Thirty-Third Edition: M100","author":"CLSI","year":"2023"},{"key":"2024090302262056900_dkae220-B7","article-title":"Broth micro-dilution reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases. 20776-1","author":"ISO","year":"2019"},{"key":"2024090302262056900_dkae220-B8","article-title":"MIC distributions and epidemiological cut-off value (ECOFF) setting. SOP 10.2","author":"EUCAST","year":"2021"},{"key":"2024090302262056900_dkae220-B9","doi-asserted-by":"crossref","first-page":"e01699-19","DOI":"10.1128\/AAC.01699-19","article-title":"In vitro activity of eravacycline against gram-negative bacilli isolated in clinical laboratories worldwide from 2013 to 2017","volume":"64","author":"Morrissey","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2024090302262056900_dkae220-B10","doi-asserted-by":"crossref","first-page":"e01715-19","DOI":"10.1128\/AAC.01715-19","article-title":"In vitro activity of eravacycline against gram-positive bacteria isolated in clinical laboratories worldwide from 2013 to 2017","volume":"64","author":"Morrissey","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2024090302262056900_dkae220-B11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jmii.2022.09.009","article-title":"In vitro susceptibility of common enterobacterales to eravacycline in Taiwan","volume":"56","author":"Huang","year":"2023","journal-title":"J Microbiol Immunol Infect"},{"key":"2024090302262056900_dkae220-B12","doi-asserted-by":"crossref","first-page":"dlad020","DOI":"10.1093\/jacamr\/dlad020","article-title":"In vitro activity of eravacycline and comparator agents against bacterial pathogens isolated from patients with cancer","volume":"5","author":"Rolston","year":"2023","journal-title":"JAC Antimicrob Resist"},{"key":"2024090302262056900_dkae220-B13","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/microorganisms10040776","article-title":"Establishment of epidemiological resistance cut-off values of aquatic Aeromonas to eight antimicrobial agents","volume":"10","author":"Lin","year":"2022","journal-title":"Microorganisms"},{"key":"2024090302262056900_dkae220-B14","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1128\/AAC.00436-16","article-title":"In vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii","volume":"60","author":"Livermore","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2024090302262056900_dkae220-B15","doi-asserted-by":"crossref","first-page":"e0119064","DOI":"10.1371\/journal.pone.0119064","article-title":"Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae","volume":"10","author":"He","year":"2015","journal-title":"PLoS ONE"},{"key":"2024090302262056900_dkae220-B16","doi-asserted-by":"crossref","first-page":"1043736","DOI":"10.3389\/fmicb.2022.1043736","article-title":"In vitro antimicrobial activity and resistance mechanisms of the new generation tetracycline agents, eravacycline, omadacycline, and tigecycline against clinical Staphylococcus aureus isolates","volume":"13","author":"Zeng","year":"2022","journal-title":"Front Microbiol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/9\/2246\/58998533\/dkae220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/9\/2246\/58998533\/dkae220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T02:27:06Z","timestamp":1725330426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/79\/9\/2246\/7714436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":16,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,7,16]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkae220","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,16]]}}}