{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:29:21Z","timestamp":1740130161271,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The COVID-19 pandemic has resulted in great incertitude and overwhelming changes in healthcare that have had a direct impact on antibiotic prescription. However, the influence of this pandemic on antibiotic consumption in patients undergoing surgery has not yet been analysed. The goal of this study was to analyse antimicrobial consumption and prescription in the same period of 2019 (pre-COVID-19), 2020 (beginning of the COVID-19 pandemic) and 2021 (established COVID-19) according to the DDD system in surgical patients at a tertiary-level hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospectively maintained database was analysed. All patients who underwent elective or emergency gastrointestinal surgery during the same period (2019, 2020 and 2021) were included. Those who received at least 1 of the 10 most frequently prescribed antimicrobials during those periods were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2975 patients were included in this study. In 2020, the number of procedures performed decreased significantly (653 versus 1154 and 1168 in 2020 versus 2019 and 2021, respectively; P\u200a=\u200a0.005). Of all patients who underwent surgery during these periods, 45.08% received at least one of the antimicrobials studied (45.8% in 2020 versus 22.9% and 22.97% in 2019 and 2021, respectively; P\u200a=\u200a0.005). Of these, 22.97% of the patients received a combination of these antimicrobials, with ceftriaxone\/metronidazole being the most frequent. Hepato-Pancreato-Biliary and Liver Transplant, Emergency Surgery and Colorectal Surgery units had higher antibiotic consumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The COVID-19 pandemic has resulted in a significant decrease in surgical activity and higher post-operative antimicrobial prescription compared with previous and subsequent years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae222","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:31:51Z","timestamp":1720629111000},"page":"2259-2262","source":"Crossref","is-referenced-by-count":0,"title":["Influence of the COVID-19 pandemic on the defined daily dose of antimicrobials in patients requiring elective and emergency surgical procedures"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8492-5599","authenticated-orcid":false,"given":"F\u00e1tima","family":"Aguilar-Del-Castillo","sequence":"first","affiliation":[{"name":"Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"\u00c1lvarez-Aguilera","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Tinoco-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Complex Abdominal Wall Unit, Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Vaca","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Herrera-Hidalgo","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Paniagua","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Padillo-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M","family":"Jim\u00e9nez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery, Hospital Universitario Virgen del Roc\u00edo , Avenue Manuel Siurot S\/N, 41013 Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"2024090302260467900_dkae222-B1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance\u2014the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect Dis"},{"author":"WHO","key":"2024090302260467900_dkae222-B2"},{"key":"2024090302260467900_dkae222-B3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0213-005X(10)70039-2","article-title":"Prudent use of antibiotics 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