{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:50:59Z","timestamp":1781650259521,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005908","name":"Federal Ministry of Food and Agriculture","doi-asserted-by":"publisher","award":["FKH: 2820HS002"],"award-info":[{"award-number":["FKH: 2820HS002"]}],"id":[{"id":"10.13039\/501100005908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MRSA is a major contributor to AMR-related deaths. The WHO\u2019s global action plan emphasizes a One Health approach, acknowledging the connection between humans and their companion animals. It is agreed on that comprehensive AMR surveillance is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study provides a large-scale overview of MRSA occurrence in cats and dogs in Germany, serving as a foundation for continuous surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study analysed all results of canine and feline bacterial diagnostic samples from a large laboratory, encompassing samples received from veterinary practices between January 2019 and December 2021. MRSA prevalence between host species, sample types and geographical distribution were compared. Additionally, data were contrasted with human MRSA surveillance data from Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Samples originated from 3491 German veterinary practices, representing 33.1% of practices and clinics nationally. Bacterial examination results from 175\u200a171 samples were analysed, identifying S. aureus in 5526 of these samples (3.2% isolation rate). S. aureus in clinical samples was more prevalent in cats (5.6%) than dogs (2.0%). Methicillin resistance was found in 17.8% of S. aureus samples and was higher in dogs (20.4%, 95%CI 18.9\u201322.0) than cats (15.6%, 95%CI 14.3\u201317.0). The highest MRSA prevalence was found in canine wound samples (32%), compared to skin\/soft tissue, respiratory tract and other (&amp;lt;23% respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study reveals a 17.8% MRSA prevalence, which is higher than the human outpatient MRSA prevalence (5.4%). Restriction and regulation of veterinary antibiotic use should be validated with AMR surveillance. Our study shows that this is feasible in companion animals with significant coverage.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkae225","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T09:41:51Z","timestamp":1721036511000},"page":"2273-2280","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of MRSA in canine and feline clinical samples from one-third of veterinary practices in Germany from 2019\u20132021"],"prefix":"10.1093","volume":"79","author":[{"given":"Leonie","family":"Feuer","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , Koserstra\u00dfe 20, Berlin 14195 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie Katharina","family":"Frenzer","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Epidemiology and Biostatistics, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , K\u00f6nigsweg 67, Berlin 14163 , Germany"},{"name":"Veterinary Centre for Resistance Research (TZR), Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 8, Berlin 14163 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-2926","authenticated-orcid":false,"given":"Roswitha","family":"Merle","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Epidemiology and Biostatistics, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , K\u00f6nigsweg 67, Berlin 14163 , Germany"},{"name":"Veterinary Centre for Resistance Research (TZR), Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 8, Berlin 14163 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Leistner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Infectious Diseases and Rheumatology, Medical Department, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Hindenburgdamm 30, Berlin 12200 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , Koserstra\u00dfe 20, Berlin 14195 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Bethe","sequence":"additional","affiliation":[{"name":"Veterinary Centre for Resistance Research (TZR), Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 8, Berlin 14163 , Germany"},{"name":"Institute of Microbiology and Epizootics, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 7, Berlin 14163 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antina","family":"L\u00fcbke-Becker","sequence":"additional","affiliation":[{"name":"Veterinary Centre for Resistance Research (TZR), Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 8, Berlin 14163 , Germany"},{"name":"Institute of Microbiology and Epizootics, School of Veterinary Medicine, Freie Universit\u00e4t Berlin , Robert-von-Ostertag-Stra\u00dfe 7, Berlin 14163 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette","family":"Klein","sequence":"additional","affiliation":[{"name":"LABOKLIN GmbH und Co. 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