{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:21:16Z","timestamp":1789874476576,"version":"4.0.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patient-reported penicillin allergy labels (PALs) are associated with adverse patient outcomes and inappropriate antibiotic prescribing. Removal of PALs via direct oral challenge (DOC) is associated with increased penicillin utilization post removal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the impact of direct delabelling (allergy label removal via medical reconciliation alone) of type A adverse drug reaction (ADR) PALs on inpatient prescribing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From January 2019 to December 2022 at two tertiary hospitals in Melbourne, patients aged \u226518 years with type A ADR PALs, as defined by the validated Antibiotic Allergy Assessment Tool, were offered direct delabelling or single-dose DOC. The primary endpoint was antibiotic use pre- and post-assessment (during index admission and 90 days post assessment). The secondary endpoint was the proportion of patients delabelled in the direct delabelling and DOC cohorts in the electronic medical record at 90 days post assessment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Allergy labels (n\u200a=\u200a4108) were assessed for 488 participants, with 490 individual type A ADR PAL assessments included. Three hundred and thirty-seven patients were directly delabelled, 69 underwent DOC and 84 were not delabelled. There was increased use of any penicillin following direct delabelling (OR 19.19, 95% CI 2.48\u2013148.36) and DOC (OR 56.98, 95% CI 6.82\u2013476.19) during the index admission, higher in the DOC group compared with direct delabelling (OR 2.97, 95% CI 1.39\u20136.37). Relabelling at 90 days was low with no statistically significant difference between direct delabelling (5\/337; 1.5%) and DOC (0\/69; 0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both direct delabelling and DOC of type A ADR PALs increased penicillin usage; however, the impact was greatest with DOC. Most patients remain delabelled at 90 days.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae270","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T21:07:07Z","timestamp":1722373627000},"page":"2640-2644","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness of direct delabelling of allergy labels in type A adverse drug reactions to penicillin: a multicentre hospitalwide prospective cohort study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-0523","authenticated-orcid":false,"given":"Kate","family":"Drummond","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Austin Health , Heidelberg, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-9421","authenticated-orcid":false,"given":"Sara","family":"Vogrin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Austin Health , Heidelberg, Victoria ,","place":["Australia"]},{"name":"Department of Infectious Diseases, The Peter Doherty Institute of Infection and Immunity, The University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Department of Medicine, St Vincent\u2019s Hospital, The University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Lambros","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-6367","authenticated-orcid":false,"given":"Jason A","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Austin Health , Heidelberg, Victoria ,","place":["Australia"]},{"name":"Department of Infectious Diseases, The Peter Doherty Institute of Infection and Immunity, The University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-2847","authenticated-orcid":false,"given":"Elise","family":"Mitri","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Austin Health , Heidelberg, Victoria ,","place":["Australia"]},{"name":"Department of Infectious Diseases, The Peter Doherty Institute of Infection and Immunity, The University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"2024093023522264900_dkae270-B1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0140-6736(18)32218-9","article-title":"Antibiotic allergy","volume":"393","author":"Blumenthal","year":"2019","journal-title":"Lancet"},{"key":"2024093023522264900_dkae270-B2","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1093\/cid\/ciw462","article-title":"Impact of reported beta-lactam allergy on inpatient outcomes: a multicentre prospective cohort study","volume":"63","author":"MacFadden","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024093023522264900_dkae270-B3","doi-asserted-by":"publisher","first-page":"k2400","DOI":"10.1136\/bmj.k2400","article-title":"Risk of methicillin-resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: a population-based matched cohort study","volume":"361","author":"Blumenthal","year":"2018","journal-title":"BMJ"},{"key":"2024093023522264900_dkae270-B4","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","article-title":"Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: a cohort study","volume":"133","author":"Macy","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2024093023522264900_dkae270-B5","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/QCO.0000000000000006","article-title":"Antimicrobial stewardship's new weapon? 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