{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:21:26Z","timestamp":1790882486773,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shionogi and Tillotts Pharma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the association of adequate empirical combination therapy (AECT) with 30-day all-cause mortality in patients with septic shock due to Pseudomonas aeruginosa bloodstream infections (BSI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicentre, retrospective cohort study analysed data from 14 public hospitals in Italy, including all consecutive adult patients admitted during 2021\u20132022 with septic shock due to P. aeruginosa BSI. We compared the outcomes of patients receiving AECT to those on adequate empirical monotherapy (AEMT) using Cox regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 98 patients who received adequate empirical antibiotic treatment for septic shock due to P. aeruginosa BSI, 24 underwent AECT and 74 were given AEMT. AECT was associated with a lower 30-day all-cause mortality (25%, six out of 24) compared to AEMT (56.8%, 42 out of 74; P\u200a=\u200a0.007). Multivariate Cox regression analysis indicated AECT as the only factor significantly associated with improved survival (aHR 0.30; 95% CI 0.12\u20130.71; P\u200a=\u200a0.006). By contrast, the use of monotherapy or combination therapy in the definitive regimen did not influence mortality (aHR 0.73; 95% CI 0.25\u20132.14; P\u200a=\u200a0.568).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AECT may be associated with reduced mortality compared to monotherapy in septic shock patients due to P. aeruginosa BSI. However, the administration of definitive adequate monotherapy or combination therapy yields similar outcomes, suggesting that once susceptibility is documented, switching to a single active in vitro drug is safe and feasible. Further studies are recommended to validate these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae296","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T13:38:24Z","timestamp":1725370704000},"page":"2846-2853","source":"Crossref","is-referenced-by-count":19,"title":["Impact of adequate empirical combination therapy on mortality in septic shock due to <i>Pseudomonas aeruginosa<\/i> bloodstream infections: a multicentre retrospective cohort study"],"prefix":"10.1093","volume":"79","author":[{"given":"Antonio","family":"Vena","sequence":"first","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","place":["Italy"]},{"name":"Clinica Malattie Infettive, IRCCS San Martino polyclinic Hospital , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Schenone","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-4297","authenticated-orcid":false,"given":"Silvia","family":"Corcione","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, University of Turin , Turin ,","place":["Italy"]},{"name":"Department of Infectious Diseases, Tufts University School of Medicine , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Giannella","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, IRCCS\u2014Sant'Orsola Polyclinic , Bologna ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pascale","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, IRCCS\u2014Sant'Orsola Polyclinic , Bologna ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-1759","authenticated-orcid":false,"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","place":["Italy"]},{"name":"Clinica Malattie Infettive, IRCCS San Martino polyclinic Hospital , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Muccio","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mornese Pinna","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, University of Turin , Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Pari","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, University of Turin , Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Giovannenze","sequence":"additional","affiliation":[{"name":"Department of Laboratory and Infectious Sciences, IRCCS A. 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