{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T09:40:37Z","timestamp":1734169237515,"version":"3.30.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>During the first pandemic of COVID-19, early empirical antibiotic use rates for pneumonia varied widely. The benefit remains hypothetical.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed the benefit of empirical antibiotic use at admission in patients hospitalized with COVID-19 pneumonia. We enrolled all adults admitted from 1 March to 30 April 2020 with symptoms for \u226414 days, a positive nasopharyngeal PCR or a highly suggestive CT scan. The primary outcome was mortality at Day 28. The secondary outcomes were transfer to the ICU, mechanical ventilation and length of hospital stay. To handle confounding-by-indication bias, we used a propensity score analysis, expressing the outcomes in the original and overlap weighted populations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 616 analysed patients, 402 (65%) received antibiotics. At Day 28, 102 patients (17%) had died, 90 (15%) had been transferred to the ICU and 24 (4%) had required mechanical ventilation. Mortality in patients who received antibiotics was higher before but not after weighting (OR 2.7, 95% CI 1.5\u20135.0, P\u200a&amp;lt;\u200a0.001 and OR 1.4, 95% CI 0.8\u20132.5, P\u200a=\u200a0.28, respectively. Antibiotic use had no benefit on: transfer to ICU before and after weighting (OR 1.3, 95% CI 0.8\u20132.3, P\u200a=\u200a0.30 and OR 1.1, 95% CI 0.6\u20131.9, P\u200a=\u200a0.78, respectively); mechanical ventilation before and after weighting (OR 0.5, 95% CI 0.2\u20131.1, P\u200a=\u200a0.079 and OR 0.75, 95% CI 0.3\u20132.0, P\u200a=\u200a0.55, respectively); and length of hospital stay before and after weighting (mean difference \u22120.02\u200a\u00b1\u200a0.5 days, P\u200a=\u200a0.97 and mean difference 0.54\u200a\u00b1\u200a0.75 days, P\u200a=\u200a0.48, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We did not find any benefit of antibiotic use in patients hospitalized with COVID-19 pneumonia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae350","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T20:29:34Z","timestamp":1726518574000},"page":"3243-3247","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of patients hospitalized in ward settings for COVID-19 pneumonia with or without early empirical antibiotics"],"prefix":"10.1093","volume":"79","author":[{"given":"A","family":"Kopp-Derouet","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, H\u00f4pitaux Saint-Louis\/Lariboisi\u00e8re, APHP , H\u00f4pital Lariboisi\u00e8re, 2, rue Ambroise Par\u00e9, 75475, Paris Cedex 10 ,","place":["France"]},{"name":"Universit\u00e9 de Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Infectious Diseases and Internal Medicine Department, GH SIF , Melun ,","place":["France"]},{"name":"DYNAMIC Unit, UPEC , Cr\u00e9teil 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