{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:03:49Z","timestamp":1792091029001,"version":"4.4.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-074"],"award-info":[{"award-number":["2022-PUMCH-B-074"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-028"],"award-info":[{"award-number":["2022-PUMCH-B-028"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-C-060"],"award-info":[{"award-number":["2022-PUMCH-C-060"]}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-044"],"award-info":[{"award-number":["2021-I2M-1-044"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the epidemiological cut-off (ECOFF) values of etimicin against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We selected 1500 isolates from five hospitals throughout five cities in China spanning from January 2018 to December 2021 in the study. Minimal inhibit concentrations (MICs) of etimicin were determined using the broth microdilution method. ECOFFs of etimicin against six species were calculated using ECOFFinder software and visual estimation following EUCAST principles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MICs of etimicin were distributed from 0.064 to &amp;gt;128\u2005mg\/L for S. aureus, from 0.125 to &amp;gt;128\u2005mg\/L for P. aeruginosa, from 0.25 to &amp;gt;128\u2005mg\/L for K. pneumoniae, P. mirabilis and A. baumannii, and from 0.5 to &amp;gt;128\u2005mg\/L for E. coli. The MIC ECOFF of etimicin was 2\u2005mg\/L for K. pneumoniae, 8\u2005mg\/L for E. coli and P. mirabilis, 16\u2005mg\/L for P. aeruginosa and A. baumannii, and the tentative ECOFF (TECOFF) of etimicin was 2\u2005mg\/L for S. aureus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>(T)ECOFFs of etimicin against E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa, A. baumannii and S. aureus were determined, which will be helpful to differentiate wild-type strains.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae414","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:46:04Z","timestamp":1733874364000},"page":"381-385","source":"Crossref","is-referenced-by-count":3,"title":["Establishment of epidemiological cut-off values of etimicin: a new fourth-generation aminoglycoside, against <i>Escherichia coli<\/i>, <i>Klebsiella pneumoniae<\/i>, <i>Proteus mirabilis<\/i>, <i>Pseudomonas aeruginosa<\/i>, <i>Acinetobacter baumannii<\/i> and <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"80","author":[{"given":"Ge","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]},{"name":"Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2632-4892","authenticated-orcid":false,"given":"Zhengyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]},{"name":"Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-3900","authenticated-orcid":false,"given":"Qiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-918X","authenticated-orcid":false,"given":"Yunsong","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyue","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of China Medical University , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhuo","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of China Medical University , Shenyang, Liaoning ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongju","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyong","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Microbiology 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