{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:07:55Z","timestamp":1791824875530,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop a scoring system to predict resistance to ceftolozane\/tazobactam in Pseudomonas aeruginosa strains isolated from respiratory specimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A case\u2013control study was conducted to evaluate the risk factors associated with resistance to ceftolozane\/tazobactam. Patients with P. aeruginosa were defined as cases if they had ceftolozane\/tazobactam-resistant strains, whereas those with ceftolozane\/tazobactam-susceptible strains were defined as test-negative controls. A predictive scoring system based on binary logistic regression coefficients was formulated to predict resistance to ceftolozane\/tazobactam. The score\u2019s performance was assessed using ROC curves and AUC. The sensitivity, specificity and predictive values of the score were determined on the basis of a cut-off point, using the Youden index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ceftolozane\/tazobactam resistance was detected in 18.4% of P. aeruginosa isolates from 473 patients. In multivariate analysis, a history of bronchoscopy [OR (95% CI)\u200a=\u200a2.1 (1.1\u20134.3), P\u200a=\u200a0.035], invasive mechanical ventilation [OR (95% CI)\u200a=\u200a2.4 (1.2\u20134.5), P\u200a=\u200a0.009], colistin\/polymyxin B use [OR (95% CI)\u200a=\u200a3.2 (1.8\u20135.7), P\u200a&amp;lt;\u200a0.001] and fluoroquinolone use [OR (95% CI)\u200a=\u200a2.3 (1.1\u20134.8), P\u200a=\u200a0.024] in the preceding month prior to P. aeruginosa isolation were significantly associated with ceftolozane\/tazobactam resistance. The AUC (95% CI) of the score was 0.734 (0.675\u20130.794), with a sensitivity of 69%, specificity of 71.8%, positive predictive value of 35.5% and negative predictive value of 91.1% at the cut-off point of 2, out of a range of 0\u20135.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In respiratory tract infections caused by P. aeruginosa, use of the proposed scoring system may reduce inappropriate use of ceftolozane\/tazobactam in empirical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae476","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T09:39:18Z","timestamp":1736933958000},"page":"788-796","source":"Crossref","is-referenced-by-count":2,"title":["A scoring system to predict resistance to ceftolozane\/tazobactam in respiratory isolates of <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-5906","authenticated-orcid":false,"given":"Eda","family":"Karadogan","sequence":"first","affiliation":[{"name":"Department of Public Health, Division of Epidemiology, Hacettepe University Faculty of Medicine , Ankara ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Sertcelik","sequence":"additional","affiliation":[{"name":"Department of Public Health, Division of Epidemiology, Hacettepe University Faculty of Medicine , Ankara ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcin Telli","family":"Dizman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine , Ankara 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