{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:49:40Z","timestamp":1784828980929,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Women, particularly those of advanced age with comorbidities and polypharmacy, are often underrepresented in clinical trials evaluating long-acting (LA) antiretroviral therapy (ART) regimens like cabotegravir and rilpivirine (CAB\u200a+\u200aRPV LA). This single-center study aims to address this gap by assessing the effectiveness, tolerability, and adherence to CAB\u200a+\u200aRPV LA, focusing on women who often have complex health profiles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this single-center, retrospective study, we analyzed virologic suppression rates, adherence and tolerability in our cohort of women living with HIV comparing their outcomes to men on the same regimen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 270 individuals (42 women and 228 men) were included. Women had a higher prevalence of comorbidities (86% versus 49%, P\u200a=\u200a0.0001), and were more likely to have used \u22655 ART lines (69% versus 29%, P\u200a&amp;lt;\u200a0.0001), and 31% were aged \u226560\u2005years compared to 13% of men (P\u200a=\u200a0.003). Despite higher rates of comorbidities and polypharmacy, women achieved virologic suppression and adherence levels comparable to men. CAB\u200a+\u200aRPV LA was well-tolerated in both groups, with no significant gender-based differences in treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CAB\u200a+\u200aRPV LA is effective and well-tolerated in women with complex ART histories, providing a viable long-acting alternative for populations traditionally underrepresented in clinical trials. These findings underscore the importance of including women in studies of novel ART regimens to ensure equitable access and outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaf038","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T04:22:35Z","timestamp":1738210955000},"page":"1084-1088","source":"Crossref","is-referenced-by-count":4,"title":["Real-world efficacy and tolerability of CAB+RPV LA in women: addressing the gender gap in HIV treatment research"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-2471","authenticated-orcid":false,"given":"Marta","family":"Rosas Cancio-Su\u00e1rez","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and IRYCIS, Hospital Universitario Ram\u00f3n y Cajal , Carretera de Colmenar Km 9.1, Madrid 28034 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, University of Alcal\u00e1 de Henares , Guadalajara Campus, Alcal\u00e1 de Henares 28801 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and IRYCIS, Hospital Universitario Ram\u00f3n y Cajal , Carretera de Colmenar Km 9.1, Madrid 28034 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos","family":"Del Campo Terr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and IRYCIS, Hospital Universitario Ram\u00f3n y Cajal , Carretera de Colmenar Km 9.1, Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Vivancos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and IRYCIS, Hospital Universitario Ram\u00f3n y Cajal , Carretera de Colmenar Km 9.1, Madrid 28034 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"G. 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