{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:26:19Z","timestamp":1788452779296,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Pfizer International"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas","award":["CB21\/13\/00009"],"award-info":[{"award-number":["CB21\/13\/00009"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, Madrid, Spain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the clinical features, antibiotic therapy and outcomes of carbapenemase-producing Enterobacterales bloodstream infection (CPE-BSI) in neutropenic patients with haematological malignancies treated with ceftazidime\/avibactam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre, international, retrospective, descriptive study of CPE-BSI episodes in neutropenic onco-haematological patients treated with ceftazidime\/avibactam as empirical and\/or targeted therapy (2017\u20132022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 54 episodes of CPE-BSI in haematological patients with neutropenia, more than half presented acute myeloid leukaemia (32, 59.5%). Klebsiella pneumoniae was the most frequently isolated pathogen (79.5%) and KPC the most prevalent carbapenemase (52%). The source of BSI was mainly endogenous (57.5%). Up to 11% presented with septic shock. Initial empirical antibiotic therapy was inadequate in 47% of cases, particularly monotherapy with meropenem or piperacillin\/tazobactam. Ceftazidime\/avibactam was administered empirically in 30% of patients and targeted in all episodes, mainly in combination with aminoglycosides, colistin or tigecycline. Nephrotoxicity occurred in 15% of patients, being attributed to aminoglycosides or colistin. Intensive care unit admission was required in 20% of cases. All-cause 7-day and 30-day case-fatality rates were 11% and 24%, respectively. Multivariate analysis showed that septic shock at BSI onset was an independent risk factor for 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ceftazidime\/avibactam proved to be safe and efficacious for the treatment of CPE-BSI in this extremely high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf120","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:29:58Z","timestamp":1743438598000},"page":"1673-1681","source":"Crossref","is-referenced-by-count":10,"title":["Ceftazidime\/avibactam for the treatment of bloodstream infection due to carbapenemase-producing Enterobacterales in onco-haematologic neutropenic patients (the TARZAN study)"],"prefix":"10.1093","volume":"80","author":[{"given":"Enric","family":"Sastre-Escol\u00e0","sequence":"first","affiliation":[{"name":"Infectious 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