{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:29:18Z","timestamp":1790735358062,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82204703"],"award-info":[{"award-number":["82204703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nature Science Foundation of Anhui Medical University","award":["2022xkj158"],"award-info":[{"award-number":["2022xkj158"]}]},{"name":"Nature Science Foundation of Anhui Medical University","award":["2023xkj148"],"award-info":[{"award-number":["2023xkj148"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Acute pancreatitis (AP) is a severe but insufficiently recognized adverse effect of tigecycline in kidney transplant (KT) recipients. This study aimed to identify the clinical characteristics and risk factors associated with tigecycline-induced AP in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A single-center retrospective study was conducted in KT recipients treated with tigecycline. The clinical characteristics of patients who developed AP were analyzed, and risk factors for tigecycline-induced AP were assessed using univariate analysis and multivariate logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>80 KT recipients were enrolled, of whom nine developed AP (incidence: 11.25%), and four died. The mean time from tigecycline administration to AP onset was 7.00 days, to symptomatic relief after discontinuation was 4.87 days, and to normalisation of pancreatic enzymes after discontinuation was 8.75 days. The analysis revealed that tacrolimus trough concentration (C0 Tac) and post-transplant acute kidney injury (AKI) were independent risk factors for tigecycline-induced AP in KT recipients. Logistic regression analysis produced a combined predictive expression: Ycombined\u200a=\u200aAKI\u200a+\u200a0.064C0 Tac\u22122.789. Receiver operating characteristic curve analysis determined that the C0 \u00a0Tac cut-off was 13.9\u2005ng\/mL. The area under the curve for C0 \u00a0Tac and combined predictor were 0.802 and 0.853, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The incidence of AP following tigecycline treatment was significantly higher in KT recipients than in non-transplant patients. Post-transplant AKI and elevated C0 Tac concentrations were identified as independent risk factors for the development of AP. Close monitoring of renal function and ensuring therapeutic monitoring of C0 Tac levels may help prevent AP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaf159","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T11:50:00Z","timestamp":1747050600000},"page":"1980-1987","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and risk factors of tigecycline-induced acute pancreatitis in kidney transplant recipients: a retrospective study"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6421-4062","authenticated-orcid":false,"given":"Lijuan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second People\u2019s Hospital of Hefei , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyi","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, School of Pharmacy, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"2025070104563473700_dkaf159-B1","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3390\/microorganisms9112272","article-title":"Carbapenemase-producing Klebsiella pneumoniae colonization and infection in solid organ transplant recipients: a single-center, retrospective study","volume":"9","author":"Pagani","year":"2021","journal-title":"Microorganisms"},{"key":"2025070104563473700_dkaf159-B2","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1111\/ajt.13317","article-title":"Outcome of transplantation using organs from donors infected or colonized with carbapenem-resistant Gram-negative bacteria","volume":"15","author":"Mularoni","year":"2015","journal-title":"Am J Transplant"},{"key":"2025070104563473700_dkaf159-B3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12941-017-0199-8","article-title":"The efficacy and safety of tigecycline for the treatment of bloodstream infections: a systematic review and meta-analysis","volume":"16","author":"Wang","year":"2017","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2025070104563473700_dkaf159-B4","doi-asserted-by":"publisher","first-page":"1215288","DOI":"10.3389\/fcimb.2023.1215288","article-title":"Safety and effectiveness of tigecycline combination therapy in renal transplant patients with infection due to carbapenem-resistant gram-negative bacteria","volume":"13","author":"Wang","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070104563473700_dkaf159-B5","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/00365540801938949","article-title":"Acute pancreatitis related to tigecycline: case report and review of the literature","volume":"40","author":"Gilson","year":"2008","journal-title":"Scand J Infect Dis"},{"key":"2025070104563473700_dkaf159-B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/jac\/dkt427","article-title":"Pancreatitis in tigecycline phase 3 and 4 clinical studies","volume":"69","author":"McGovern","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2025070104563473700_dkaf159-B7","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.2147\/ijgm.S410542","article-title":"The Spectrum of tigecycline-induced pancreatitis in clinical characteristics, diagnosis, and management","volume":"16","author":"Pan","year":"2023","journal-title":"Int J Gen Med"},{"key":"2025070104563473700_dkaf159-B8","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1111\/bcp.15776","article-title":"Clinical characteristics and risk factors for tigecycline-induced pancreatitis in a tertiary hospital: a retrospective study","volume":"89","author":"Tan","year":"2023","journal-title":"Br J Clin Pharmacol"},{"key":"2025070104563473700_dkaf159-B9","doi-asserted-by":"publisher","first-page":"e0222169","DOI":"10.1371\/journal.pone.0222169","article-title":"Acute pancreatitis risk after kidney transplantation: propensity score matching analysis of a national cohort","volume":"14","author":"Chuang","year":"2019","journal-title":"PLoS One"},{"key":"2025070104563473700_dkaf159-B10","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.3390\/jcm13123366","article-title":"Exploring acute pancreatitis in kidney transplant recipients: a multicentre retrospective cohort analysis of incidence, causes, and clinical outcomes","volume":"13","author":"Basic-Jukic","year":"2024","journal-title":"J Clin Med"},{"key":"2025070104563473700_dkaf159-B11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12879-018-3103-z","article-title":"Tigecycline-induced acute pancreatitis in a renal transplant patient: a case report and literature review","volume":"18","author":"Lin","year":"2018","journal-title":"BMC Infect Dis"},{"key":"2025070104563473700_dkaf159-B12","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/jcpt.13212","article-title":"Analysis of clinical characteristics of tigecycline-induced acute pancreatitis","volume":"45","author":"Fang","year":"2020","journal-title":"J Clin Pharm Ther"},{"key":"2025070104563473700_dkaf159-B13","doi-asserted-by":"publisher","first-page":"e13593","DOI":"10.1111\/tid.13593","article-title":"A case report of tigecycline induced acute pancreatitis in a renal transplant patient and review of the literature: should we avoid tigecycline in patients on calcineurin inhibitors?","volume":"23","author":"Yazirli","year":"2021","journal-title":"Transpl Infect Dis"},{"key":"2025070104563473700_dkaf159-B14","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.3748\/wjg.v26.i22.2902","article-title":"Ever-increasing diversity of drug-induced pancreatitis","volume":"26","author":"Weissman","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2025070104563473700_dkaf159-B15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann Intern Med"},{"key":"2025070104563473700_dkaf159-B16","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed graft function in the kidney transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transplant"},{"key":"2025070104563473700_dkaf159-B17","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/cc5713","article-title":"Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury","volume":"11","author":"Mehta","year":"2007","journal-title":"Crit Care"},{"key":"2025070104563473700_dkaf159-B18","doi-asserted-by":"publisher","first-page":"768193","DOI":"10.1155\/2012\/768193","article-title":"Acute pancreatitis after kidney transplantation","volume":"2012","author":"Tabakovic","year":"2012","journal-title":"Case Rep Transplant"},{"key":"2025070104563473700_dkaf159-B19","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.mayocpiqo.2019.03.006","article-title":"Acute pancreatitis in advanced chronic kidney disease and kidney transplant recipients: results of a US nationwide analysis","volume":"3","author":"Kroner","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"2025070104563473700_dkaf159-B20","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2165\/00002018-200831100-00002","article-title":"Drug-induced pancreatitis: incidence, management and prevention","volume":"31","author":"Balani","year":"2008","journal-title":"Drug Saf"},{"key":"2025070104563473700_dkaf159-B21","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/s41419-019-1969-3","article-title":"Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"2025070104563473700_dkaf159-B22","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3109\/10715762.2013.804624","article-title":"Chronic pancreatitis: role of oxidative stress and antioxidants","volume":"47","author":"Bhardwaj","year":"2013","journal-title":"Free Radic Res"},{"key":"2025070104563473700_dkaf159-B23","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1399-0012.2009.01088.x","article-title":"Challenges in diagnosing acute pancreatitis in renal transplant patients","volume":"23","author":"Taylor","year":"2009","journal-title":"Clin Transplant"},{"key":"2025070104563473700_dkaf159-B24","doi-asserted-by":"publisher","first-page":"1231320","DOI":"10.3389\/fphar.2023.1231320","article-title":"Risk factors for drug-related acute pancreatitis: an analysis of the FDA adverse event reporting system (FAERS)","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"key":"2025070104563473700_dkaf159-B25","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00228-017-2207-5","article-title":"Intravenous methylprednisolone induced acute pancreatitis","volume":"73","author":"Yahiaoui","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"2025070104563473700_dkaf159-B26","doi-asserted-by":"publisher","first-page":"102230","DOI":"10.1016\/j.trim.2025.102230","article-title":"Drug-induced acute pancreatitis following dose increase of mycophenolate mofetil in a kidney transplant recipient: a case report and literature review","volume":"90","author":"Abou-Jaoude","year":"2025","journal-title":"Transpl Immunol"},{"key":"2025070104563473700_dkaf159-B27","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1046\/j.1365-2168.2000.01577.x","article-title":"Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants","volume":"87","author":"Bicknell","year":"2000","journal-title":"Br J Surg"},{"key":"2025070104563473700_dkaf159-B28","doi-asserted-by":"publisher","first-page":"843870","DOI":"10.3389\/fmed.2022.843870","article-title":"Case report: acute pancreatitis associated with tacrolimus in kidney transplantation and a review of the literature","volume":"9","author":"Ding","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2025070104563473700_dkaf159-B29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/jcpt.13269","article-title":"Acute pancreatitis due to tacrolimus in kidney transplant and review of the literature","volume":"46","author":"Liu","year":"2021","journal-title":"J Clin Pharm Ther"},{"key":"2025070104563473700_dkaf159-B30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12882-019-1395-x","article-title":"A case report: acute pancreatitis associated with tacrolimus in kidney transplantation","volume":"20","author":"Xu","year":"2019","journal-title":"BMC Nephrol"},{"key":"2025070104563473700_dkaf159-B31","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1053\/j.ajkd.2010.10.040","article-title":"Altered bioavailability of tacrolimus following intravenous administration of tigecycline","volume":"57","author":"Pavan","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"2025070104563473700_dkaf159-B32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/nep.13594","article-title":"Beware of drug interaction between tigecycline and tacrolimus","volume":"25","author":"Chow","year":"2020","journal-title":"Nephrology (Carlton)"},{"key":"2025070104563473700_dkaf159-B33","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s10096-020-04121-1","article-title":"Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review","volume":"41","author":"Yaghoubi","year":"2022","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2025070104563473700_dkaf159-B34","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.2147\/dddt.S365512","article-title":"Population pharmacokinetics of tigecycline: a systematic review","volume":"16","author":"Zhou","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"2025070104563473700_dkaf159-B35","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1111\/bcp.14692","article-title":"Population pharmacokinetics and exposure-response analysis of tigecycline in patients with hospital-acquired pneumonia","volume":"87","author":"Zhou","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"2025070104563473700_dkaf159-B36","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1128\/aac.01636-05","article-title":"Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections","volume":"50","author":"Van Wart","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2025070104563473700_dkaf159-B37","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1128\/aac.01414-09","article-title":"Tigecycline population pharmacokinetics in patients with community- or hospital-acquired pneumonia","volume":"54","author":"Rubino","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2025070104563473700_dkaf159-B38","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1097\/ftd.0000000000000784","article-title":"Safety and efficacy of tigecycline in intensive care unit patients based on therapeutic drug monitoring","volume":"42","author":"Fan","year":"2020","journal-title":"Ther Drug Monit"},{"key":"2025070104563473700_dkaf159-B39","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1128\/aac.00277-10","article-title":"Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia","volume":"56","author":"Rubino","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2025070104563473700_dkaf159-B40","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/jac\/dkae396","article-title":"Serum concentration threshold and risk factors of tigecycline-induced hypofibrinogenaemia in critically ill patients","volume":"80","author":"Li","year":"2025","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/7\/1980\/63302558\/dkaf159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/7\/1980\/63302558\/dkaf159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:56:36Z","timestamp":1751360196000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/80\/7\/1980\/8141291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,5,23]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaf159","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,5,23]]}}}