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Times to treatment discontinuation (TD) and to virological failure (VF50, two consecutive HIV-RNA &amp;gt;50 copies\/mL or one &amp;gt;1000 copies\/mL followed by ART switch) were estimated by the Kaplan\u2013Meier method. Cox regression models, adjusted for age, sex and mode of HIV transmission and stratified by the centre, were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 583 PWH started LA cabotegravir\/rilpivirine. Six VF50 were observed, with a 1 year estimated cumulative probability of virological failure of 1.2% (95% CI, 0.5%\u20133.0%). Resistance-associated mutations for rilpivirine and cabotegravir were detected in 3\/4 and 4\/4 participants with VF50, respectively, for which the genotypic resistance test was performed.<\/jats:p>\n                    <jats:p>The 1 year cumulative probability of TD was 11.4% (95% CI, 8.6%\u201314.9%), mainly caused by toxicity\/adverse events (73.2%). Multivariable analysis identified heterosexual intercourse and IV drug use as significant risk factors for TD compared with MSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis demonstrated the short-term effectiveness of cabotegravir\/rilpivirine in a real-life setting showing minimal incidence of virological failure but a notable probability of discontinuation due to toxicity or adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf184","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:47:02Z","timestamp":1748418422000},"page":"2169-2178","source":"Crossref","is-referenced-by-count":20,"title":["Effectiveness and predictors of treatment discontinuation of long-acting cabotegravir\/rilpivirine in virologically suppressed people with HIV: real-life data from the Icona 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