{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:44:39Z","timestamp":1790959479413,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council, Taiwan","doi-asserted-by":"publisher","award":["113-2314-B-002-126-MY3"],"award-info":[{"award-number":["113-2314-B-002-126-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"publisher","award":["MOHW113-TDU-B-211-114006"],"award-info":[{"award-number":["MOHW113-TDU-B-211-114006"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114-SS0012"],"award-info":[{"award-number":["114-SS0012"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study is to evaluate the benefit of early appropriate antibiotics in vancomycin-resistant Enterococcus (VRE) bloodstream infections (BSIs) amid increasing incidence and limited evidence supporting empirical VRE-active therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a cohort study (2010\u201323) involving patients with VRE BSI who received empiric Gram-positive coverage. Patients who did not receive VRE-active therapy (daptomycin or linezolid) were excluded. Based on their initial regimen, patients were classified into an empiric anti-VRE group or a glycopeptide (vancomycin or teicoplanin) group. The primary outcome was 28-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 134 patients: 46 in the empiric anti-VRE group and 88 in the glycopeptide group. The 28-day mortality rate was 53.7%. All glycopeptide recipients switched to daptomycin, and 29 of the 46 (63%) patients in the empiric anti-VRE group also received daptomycin. Time to VRE-active therapy was shorter in the empiric anti-VRE group (0 versus 2\u2005days; P\u200a&amp;lt;\u200a0.001), and each day\u2019s delay correlated with higher mortality (0\u2005day: 37.0%, 1\u2005day: 57.7%, \u22652\u2005days: 64.5%; P\u200a=\u200a0.02). The empiric anti-VRE group had a lower 28-day mortality rate (37.0% versus 62.5%, P\u200a=\u200a0.006). Multivariable analysis adjusting for comorbidities, steroid use, infection focus and bacteraemia severity indicated that empiric anti-VRE therapy was independently associated with lower mortality (adjusted OR 0.41; 95% CI, 0.17\u20130.98; P\u200a=\u200a0.046).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among patients with VRE BSI requiring empiric Gram-positive coverage, anti-VRE therapy was associated with reduced 28-day mortality compared with glycopeptides, even both groups eventually received VRE-active antibiotics. This highlights the critical role of timely, appropriate antibiotic to improve VRE BSI outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaf225","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T07:55:54Z","timestamp":1750924554000},"page":"2408-2416","source":"Crossref","is-referenced-by-count":6,"title":["Impact of empiric anti-VRE therapy on survival in vancomycin-resistant enterococcal bloodstream infection"],"prefix":"10.1093","volume":"80","author":[{"given":"Tao-Hung","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei 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