{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:35:34Z","timestamp":1775583334749,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SCYNEXIS, Inc"},{"name":"Canisius-Wilhelmina Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"DOI":"10.1093\/jac\/dkaf240","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:20:38Z","timestamp":1752729638000},"page":"3165-3166","source":"Crossref","is-referenced-by-count":3,"title":["SCY-247, a novel second-generation triterpenoid antifungal, demonstrates high\n                    <i>in vitro<\/i>\n                    activity against genetically diverse\n                    <i>Candida auris<\/i>\n                    isolates, including\n                    <i>FKS1<\/i>\n                    mutants"],"prefix":"10.1093","volume":"80","author":[{"given":"Bram","family":"Spruijtenburg","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]},{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theun","family":"de Groot","sequence":"additional","affiliation":[{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]},{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eelco F J","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]},{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"2025110817243488100_dkaf240-B1","doi-asserted-by":"publisher","first-page":"2400729","DOI":"10.2807\/1560-7917.ES.2024.29.45.2400729","article-title":"Should all hospitalised patients colonised with Candida auris be considered for isolation?","volume":"29","author":"Meijer","year":"2024","journal-title":"Euro Surveill"},{"key":"2025110817243488100_dkaf240-B2","doi-asserted-by":"publisher","first-page":"100878","DOI":"10.1016\/S2666-5247(24)00101-0","article-title":"Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study","volume":"5","author":"Suphavilai","year":"2024","journal-title":"Lancet Microbe"},{"key":"2025110817243488100_dkaf240-B3","doi-asserted-by":"publisher","first-page":"e0132423","DOI":"10.1128\/aac.01324-23","article-title":"In vitro activity of ibrexafungerp against clinically relevant echinocandin-resistant Candida strains","volume":"68","author":"Aldejohann","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"2025110817243488100_dkaf240-B4","doi-asserted-by":"publisher","first-page":"e01988-20","DOI":"10.1128\/AAC.01988-20","article-title":"A second-generation fungerp analog, SCY-247, shows potent in vitro activity against Candida auris and other clinically relevant fungal isolates","volume":"65","author":"Chu","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2025110817243488100_dkaf240-B5","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/myc.13655","article-title":"Whole genome sequencing analysis demonstrates therapy-induced echinocandin resistance in Candida auris isolates","volume":"66","author":"Spruijtenburg","year":"2023","journal-title":"Mycoses"},{"key":"2025110817243488100_dkaf240-B6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3390\/jof9050529","article-title":"Evaluation of a novel FKS1 R1354H mutation associated with caspofungin resistance in Candida auris using the CRISPR-cas9 system","volume":"9","author":"Kiyohara","year":"2023","journal-title":"J Fungi (Basel)"},{"key":"2025110817243488100_dkaf240-B7","author":"EUCAST"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/11\/3165\/63780550\/dkaf240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/11\/3165\/63780550\/dkaf240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:24:38Z","timestamp":1762640678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/80\/11\/3165\/8203699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,7,17]]},"published-print":{"date-parts":[[2025,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaf240","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,7,17]]}}}