{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:14:17Z","timestamp":1763972057205,"version":"3.45.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002066","name":"GSK","doi-asserted-by":"publisher","award":["207965"],"award-info":[{"award-number":["207965"]}],"id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from community-acquired respiratory tract infections (CA-RTIs) collected in 2018\u201321 from Ukraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MICs were determined by CLSI broth microdilution test, and susceptibility data were interpreted using CLSI, EUCAST (dose-specific) and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>S. pneumoniae (n\u200a=\u200a64) and H. influenzae (n\u200a=\u200a76) isolates were collected in 2018\u201321. Antibiotic susceptibility was 82.8% for pneumococci penicillin-susceptible by CLSI oral\/EUCAST low-dose breakpoints and 98.4% by EUCAST high-dose\/CLSI intravenous breakpoints. Fluoroquinolones were the most active (100% susceptible). CLSI susceptibility of 85.9%\u201396.9% was also observed for amoxicillin, amoxicillin\/clavulanic acid and cephalosporins. Tetracycline and macrolide susceptibility was 73.4%\u201376.6%, and trimethoprim\/sulfamethoxazole was 59.4%. EUCAST susceptibility was similar if high-dose regimens were chosen, although susceptibility to trimethoprim\/sulfamethoxazole was 79.7%. Most H. influenzae isolates were \u03b2-lactamase negative (n = 72, 94.7%) with &amp;gt;94.7% susceptibility, except for trimethoprim\/sulfamethoxazole (61.8% by CLSI\/EUCAST low-dose, 68.4% by EUCAST high-dose). Susceptibility using EUCAST breakpoints was similar to CLSI, except cefuroxime (oral) with 0% of isolates susceptible versus 100% by CLSI. Cefaclor susceptibility was 11.8% using PK\/PD breakpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For H. influenzae, 100% susceptibility (CLSI) was observed to amoxicillin\/clavulanic acid, macrolides, most cephalosporins and tetracycline. S. pneumoniae susceptibility was 100% to fluoroquinolones, 90.6%\u201396.9% to third-generation cephalosporins and 96.9% to amoxicillin and amoxicillin\/clavulanic acid. This is consistent with previous resistance surveillance in Ukraine. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf287","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:52:02Z","timestamp":1753271522000},"page":"iii68-iii82","source":"Crossref","is-referenced-by-count":0,"title":["Results from the Survey of Antibiotic Resistance (SOAR) 2018\u201321 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints"],"prefix":"10.1093","volume":"80","author":[{"given":"Didem","family":"Torumkuney","sequence":"first","affiliation":[{"name":"Infectious Disease Research Unit, GSK , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bratus","sequence":"additional","affiliation":[{"name":"Diagnostic Center, Dnipropetrovsk State Medical Academy, Dnipropetrovsk , Kyiv ,","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Yuvko","sequence":"additional","affiliation":[{"name":"Diagnostic Center, Dnipropetrovsk State Medical Academy, Dnipropetrovsk , Kyiv ,","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana","family":"Pertseva","sequence":"additional","affiliation":[{"name":"Medical Science, Dnipropetrovsk State Medical Academy , Dnipro ,","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Antimicrobial Focus Ltd. , Sawbridgeworth ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana Ossaille","family":"Beltrame","sequence":"additional","affiliation":[{"name":"a Departamento de Microbiologia M\u00e9dica, Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Medical & Scientific Affairs, GSK , Mumbai ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2025112403093582200_dkaf287-B1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(21)00630-9","article-title":"Community-acquired pneumonia","volume":"398","author":"Aliberti","year":"2021","journal-title":"Lancet"},{"key":"2025112403093582200_dkaf287-B2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/MCC.0000000000000550","article-title":"Community-acquired pneumonia as an emergency condition","volume":"24","author":"Cill\u00f3niz","year":"2018","journal-title":"Curr Opin Crit Care"},{"key":"2025112403093582200_dkaf287-B3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1056\/NEJMoa1500245","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. adults","volume":"373","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"2025112403093582200_dkaf287-B4","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/cid\/civ1214","article-title":"Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia","volume":"62","author":"Gadsby","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2025112403093582200_dkaf287-B5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/17476348.2019.1562339","article-title":"The burden of community-acquired bacterial pneumonia in the era of antibiotic resistance","volume":"13","author":"Peyrani","year":"2019","journal-title":"Expert Rev Respir Med"},{"key":"2025112403093582200_dkaf287-B6","doi-asserted-by":"publisher","first-page":"e000214","DOI":"10.1099\/mgen.0.000214","article-title":"The return of Pfeiffer's bacillus: rising incidence of ampicillin resistance in Haemophilus influenzae","volume":"4","author":"Heinz","year":"2018","journal-title":"Microb Genom"},{"key":"2025112403093582200_dkaf287-B7","author":"World Health Organization"},{"key":"2025112403093582200_dkaf287-B8","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1093\/jac\/dkw332","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore","volume":"71","author":"Torumkuney","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2025112403093582200_dkaf287-B9","author":"CLSI"},{"key":"2025112403093582200_dkaf287-B10","author":"CLSI"},{"key":"2025112403093582200_dkaf287-B11","author":"European Committee on Antimicrobial Susceptibility Testing"},{"issue":"Suppl 1","key":"2025112403093582200_dkaf287-B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.otohns.2003.12.003","article-title":"Antimicrobial treatment guidelines for acute bacterial rhinosinusitis","volume":"130","author":"Anon","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"Suppl 1","key":"2025112403093582200_dkaf287-B13","doi-asserted-by":"publisher","first-page":"i100","DOI":"10.1093\/jac\/dkaa087","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2016-17 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints","volume":"75","author":"Torumkuney","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 1","key":"2025112403093582200_dkaf287-B14","doi-asserted-by":"publisher","first-page":"i63","DOI":"10.1093\/jac\/dkw068","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in Ukraine","volume":"71","author":"Feshchenko","year":"2016","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 5","key":"2025112403093582200_dkaf287-B15","doi-asserted-by":"publisher","first-page":"v28","DOI":"10.1093\/jac\/dky069","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2014-16 in Ukraine and the Slovak republic","volume":"73","author":"Torumkuney","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2025112403093582200_dkaf287-B16","doi-asserted-by":"publisher","first-page":"e2022238","DOI":"10.23750\/abm.v93i2.13137","article-title":"Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine","volume":"93","author":"Kaidashev","year":"2022","journal-title":"Acta Biomed"},{"key":"2025112403093582200_dkaf287-B17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5588\/ijtld.17.0254","article-title":"Alarming levels of multidrug-resistant tuberculosis in Ukraine: results from the first national survey","volume":"22","author":"Pavlenko","year":"2018","journal-title":"Int J Tuberc Lung Dis"},{"key":"2025112403093582200_dkaf287-B18","first-page":"2069","article-title":"Bloodstream infections and antimicrobial resistance of responsible pathogens in Ukraine: results of a multicenter study (2013-2015)","volume":"72","author":"Salmanov","year":"2019","journal-title":"Wiad Lek"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/Supplement_3\/iii68\/65487227\/dkaf287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/Supplement_3\/iii68\/65487227\/dkaf287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:09:46Z","timestamp":1763971786000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/80\/Supplement_3\/iii68\/8340891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":18,"journal-issue":{"issue":"Supplement_3","published-online":{"date-parts":[[2025,11,24]]},"published-print":{"date-parts":[[2025,11,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaf287","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9]]}}}