{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:44:11Z","timestamp":1775511851819,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002066","name":"GSK","doi-asserted-by":"publisher","award":["207965"],"award-info":[{"award-number":["207965"]}],"id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Antibiotic susceptibility determination of Streptococcus pneumoniae and Haemophilus influenzae from community-acquired respiratory infections collected in 2020\u201321 from two hospitals in Ho Chi Minh City, Vietnam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MICs were determined by CLSI broth microdilution; susceptibility was interpreted based on CLSI, EUCAST and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 144 S. pneumoniae and 191 H. influenzae isolates were collected. S. pneumoniae susceptibility to amoxicillin and amoxicillin\/clavulanic acid (2:1) was 56.9% and 56.3% (CLSI), 29.2% and 25.7% (EUCAST high-dose) and 78.5% using high-dose amoxicillin (4\u2005g\/0.25\u2005g\/day, PK\/PD). Susceptibility to ceftriaxone was 91.7% by EUCAST (high-dose) and 50.7% by CLSI or PK\/PD. Pneumococcal cefotaxime susceptibility was 61.8% by CLSI (29.9%, EUCAST). Penicillin susceptibility was 69.4% by CLSI intravenous\/EUCAST high-dose, but 6.3% using CLSI oral\/EUCAST low-dose breakpoints. Tetracyclines, macrolides and trimethoprim\/sulfamethoxazole had 5.6%\u201316.7% susceptibility.<\/jats:p>\n                    <jats:p>Among H. influenzae isolates, 59.7% were \u03b2-lactamase-negative, of which 87.7% and 74.6% were ampicillin-resistant (BLNAR) following EUCAST and CLSI criteria, respectively. H. influenzae fluoroquinolone, macrolide and tetracycline susceptibility reached 62.0%\u201389.5% (CLSI, EUCAST); macrolide susceptibility was 3.7%\u20135.8% (PK\/PD). All were susceptible to ceftriaxone (all breakpoints) and cefotaxime (CLSI, PK\/PD); cefotaxime susceptibility was 15.7% by EUCAST. H. influenzae amoxicillin\/clavulanic acid susceptibility was 45.5% (EUCAST) and 32.5% (CLSI) but increased to 82.8% with high-dose (4\u2005g\/0.25\u2005g\/day, PK\/PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The hospitals showed high rates of penicillin-resistant S. pneumoniae and BLNAR H. influenzae. S. pneumoniae showed low susceptibility to macrolides and several cephalosporins. H. influenzae fluoroquinolone susceptibility was 88.0%\u201389.0% (CLSI). Future surveillance across Vietnam will help understand susceptibility trends over time and regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf290","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:53:48Z","timestamp":1753271628000},"page":"iii114-iii128","source":"Crossref","is-referenced-by-count":1,"title":["Results from the Survey of Antibiotic Resistance (SOAR) 2020\u201321 in Vietnam: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints"],"prefix":"10.1093","volume":"80","author":[{"given":"Didem","family":"Torumkuney","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Unit, GSK , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Hung","family":"Van","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vietnam Research and Development Institute of Clinical Microbiology (VCM) , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Quoc","family":"Thinh","sequence":"additional","affiliation":[{"name":"Pediatric Department, Pediatric 1 Hospital , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hawser","sequence":"additional","affiliation":[{"name":"Global Affairs, IHMA Europe S\u00e0rl , Monthey ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhashri","family":"Kundu","sequence":"additional","affiliation":[{"name":"Infectious Diseases - Antibiotic Resistance, GSK , Singapore,","place":["Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc","family":"Truong Ha Lan","sequence":"additional","affiliation":[{"name":"Vaccine Department, GSK , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Medical & Scientific Affairs, GSK , Mumbai ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2025112403094458400_dkaf290-B1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","journal-title":"Lancet"},{"key":"2025112403094458400_dkaf290-B2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1056\/NEJMoa1500245","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. adults","volume":"373","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"2025112403094458400_dkaf290-B3","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/cid\/civ1214","article-title":"Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia","volume":"62","author":"Gadsby","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2025112403094458400_dkaf290-B4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/17476348.2019.1562339","article-title":"The burden of community-acquired bacterial pneumonia in the era of antibiotic resistance","volume":"13","author":"Peyrani","year":"2019","journal-title":"Expert Rev Respir Med"},{"key":"2025112403094458400_dkaf290-B5","doi-asserted-by":"publisher","first-page":"e000214","DOI":"10.1099\/mgen.0.000214","article-title":"The return of Pfeiffer\u2019s bacillus: rising incidence of ampicillin resistance in Haemophilus influenzae","volume":"4","author":"Heinz","year":"2018","journal-title":"Microb Genom"},{"key":"2025112403094458400_dkaf290-B6","author":"World Health Organization"},{"key":"2025112403094458400_dkaf290-B7","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1093\/jac\/dkw332","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2012\u201314 in Thailand, India, South Korea and Singapore","volume":"71","author":"Torumkuney","year":"2016","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 1","key":"2025112403094458400_dkaf290-B8","doi-asserted-by":"publisher","first-page":"i19","DOI":"10.1093\/jac\/dkaa082","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2016\u201318 in Vietnam, Cambodia, Singapore and the Philippines: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic\/pharmacodynamic (PK\/PD) breakpoints","volume":"75","author":"Torumkuney","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2025112403094458400_dkaf290-B9","author":"CLSI"},{"key":"2025112403094458400_dkaf290-B10","author":"CLSI"},{"key":"2025112403094458400_dkaf290-B11","author":"European Committee on Antimicrobial Susceptibility Testing"},{"issue":"Suppl 1","key":"2025112403094458400_dkaf290-B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.otohns.2003.12.003","article-title":"Antimicrobial treatment guidelines for acute bacterial rhinosinusitis","volume":"130","author":"Anon","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2025112403094458400_dkaf290-B13","doi-asserted-by":"publisher","first-page":"i93","DOI":"10.1093\/jac\/dkw069","article-title":"Results from the Survey of Antibiotic Resistance (SOAR) 2009\u201311 in Vietnam","volume":"71","author":"Van","year":"2016","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/Supplement_3\/iii114\/65487265\/dkaf290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/Supplement_3\/iii114\/65487265\/dkaf290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:09:47Z","timestamp":1763971787000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/80\/Supplement_3\/iii114\/8340895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":13,"journal-issue":{"issue":"Supplement_3","published-online":{"date-parts":[[2025,11,24]]},"published-print":{"date-parts":[[2025,11,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaf290","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9]]}}}