{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:13:43Z","timestamp":1775880823045,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary tract infections (UTI) in oncological patients can lead to bacteraemia (bUTI), increasing morbidity and mortality. This study assessed the characteristics, outcomes and recurrence of bUTI in oncological patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at Hospital Clinic, Barcelona, from 2008 to 2019. All episodes of bUTI in oncological patients were analysed. Multivariable regression models identified independent risk factors for multidrug-resistant (MDR) Gram-negative bacilli (GNB), recurrent bUTI and related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 561 bUTI episodes were identified in 478 oncological patients. Urinary tract involvement due to neoplasm was present in 62.2%, and 59.4% had urinary tract instrumentation. Prior UTI-related admission without bacteraemia was reported in 63.8%. Following bUTI, oncological treatment was delayed in 47% and stopped in 33.6% of cases. GNB caused 87.3% of episodes, with Escherichia coli and Klebsiella spp. being the most common pathogens. Enterococcus spp. and Pseudomonas aeruginosa were frequent, particularly in patients with urinary instrumentation. MDR-GNB caused 19.6% of episodes, and 23.4% of cases received inappropriate empirical antibiotic therapy (IEAT). Recurrent bUTI occurred in 14.0% of patients. A simple predictive score efficiently identified patients at high risk of recurrence. Thirty-day mortality was 15.3%, and bUTI-related mortality was 10.7%, with absence of fever, septic shock and carbapenemase-producing Enterobacterales linked to higher related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>bUTI in oncological patients is predominantly caused by GNB, with high rates of MDR isolates and high mortality. IEAT is common, and recurrence is significant, highlighting the need for targeted preventive strategies and optimized empirical therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf335","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:35:14Z","timestamp":1756467314000},"page":"3026-3033","source":"Crossref","is-referenced-by-count":1,"title":["Multidrug resistance and recurrence in urinary bacteraemia among cancer patients"],"prefix":"10.1093","volume":"80","author":[{"given":"Ignacio","family":"Grafia","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]},{"name":"Internal Medicine Department, Complex Hospitalari Universitari Mois\u00e9s Broggi , Sant Joan Desp\u00ed, Barcelona ,","place":["Spain"]},{"name":"Department of Medicine, Universitat de Barcelona (UB) , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Moll-Febrer","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solanche Jasmin","family":"Santill\u00e1n","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lillo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e9stor","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Microbiology Department, Centre Diagn\u00f2stic Biom\u00e8dic, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Rico-Caballero","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateu","family":"Espasa-Soley","sequence":"additional","affiliation":[{"name":"Microbiology Department, Centre Diagn\u00f2stic Biom\u00e8dic, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3412-7563","authenticated-orcid":false,"given":"Daniel N","family":"Marco","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pitart","sequence":"additional","affiliation":[{"name":"Microbiology Department, Centre Diagn\u00f2stic Biom\u00e8dic, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Marco-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Supportive and Palliative Care in Cancer Unit, Hospital Cl\u00ednic , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Internal Medicine Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Zamora","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Padrosa","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Garcia de Herreros","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]},{"name":"Translational Genomics and Targeted Therapeutics in Solid Tumors Lab, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2014Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB-IDIBAPS) , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Herrera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Viladot","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Llavata","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Tuca","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-0811","authenticated-orcid":false,"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-0217","authenticated-orcid":false,"given":"Pedro","family":"Puerta-Alcalde","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universitat de Barcelona (UB) , Barcelona ,","place":["Spain"]},{"name":"Infectious Diseases Department, Hospital Cl\u00ednic-IDIBAPS , Barcelona ,","place":["Spain"]},{"name":"Infectious Disease Department, Hospital Germans Trias i Pujol , Badalona ,","place":["Spain"]},{"name":"Infection in Immunocompromised Patients Unit, Fundaci\u00f3 Lluita Contra les Infeccions , Badalona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2025110817253244500_dkaf335-B1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Flores-Mireles","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"2025110817253244500_dkaf335-B2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s40121-017-0146-1","article-title":"Infections in cancer patients with solid tumors: a review","volume":"6","author":"Rolston","year":"2017","journal-title":"Infect Dis Ther"},{"key":"2025110817253244500_dkaf335-B3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1080\/21505594.2016.1141161","article-title":"Bloodstream infections in patients with solid tumors","volume":"7","author":"Gudiol","year":"2016","journal-title":"Virulence"},{"key":"2025110817253244500_dkaf335-B4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jhin.2020.09.006","article-title":"Acquisition of MDR-GNB in hospital settings: a systematic review and meta-analysis focusing on ESBL-E","volume":"106","author":"Vink","year":"2020","journal-title":"J Hosp Infect"},{"key":"2025110817253244500_dkaf335-B5","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41409-019-0701-3","article-title":"Changing epidemiology of bloodstream infection in a 25-years hematopoietic stem cell transplant program: current challenges and pitfalls on empiric antibiotic treatment impacting outcomes","volume":"55","author":"Puerta-Alcalde","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"2025110817253244500_dkaf335-B6","doi-asserted-by":"publisher","first-page":"e0214223","DOI":"10.1128\/spectrum.02142-23","article-title":"Epidemiology and risk factors for recurrence in biliary source bloodstream infection episodes in oncological patients","volume":"11","author":"Grafia","year":"2023"},{"key":"2025110817253244500_dkaf335-B7","doi-asserted-by":"publisher","first-page":"S94","DOI":"10.1086\/320182","article-title":"Variations in the prevalence of strains expressing an extended-spectrum \u03b2-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region","volume":"32","author":"Winokur","year":"2001","journal-title":"Clin Infect Dis"},{"key":"2025110817253244500_dkaf335-B8","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1186\/s12879-021-06243-z","article-title":"Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance","volume":"21","author":"Amanati","year":"2021","journal-title":"BMC Infect Dis"},{"key":"2025110817253244500_dkaf335-B9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12885-023-10869-4","article-title":"Urinary tract infection after radiation therapy or radical prostatectomy on the prognosis of patients with prostate cancer: a population-based study","volume":"23","author":"Hyun","year":"2023","journal-title":"BMC Cancer"},{"key":"2025110817253244500_dkaf335-B10","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1093\/cid\/ciz319","article-title":"Inappropriate empirical antibiotic treatment in high-risk neutropenic patients with bacteremia in the era of multidrug resistance","volume":"70","author":"Martinez-Nadal","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2025110817253244500_dkaf335-B11","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00345-018-2181-2","article-title":"Urinary tract infections following radical cystectomy and urinary diversion: a review of 1133 patients","volume":"36","author":"Clifford","year":"2018","journal-title":"World J Urol"},{"key":"2025110817253244500_dkaf335-B12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.11604\/pamj.2020.36.169.21038","article-title":"Acute urinary tract infection in patients with underlying benign prostatic hyperplasia and prostate cancer","volume":"36","author":"Tolani","year":"2020","journal-title":"Pan Afr Med J"},{"key":"2025110817253244500_dkaf335-B13","doi-asserted-by":"publisher","first-page":"e000018","DOI":"10.1136\/esmoopen-2015-000018","article-title":"Critically ill patients with cancer: chances and limitations of intensive care medicine-a narrative review","volume":"1","author":"Schellongowski","year":"2016","journal-title":"ESMO Open"},{"key":"2025110817253244500_dkaf335-B14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jcrc.2020.01.027","article-title":"One-year survival in patients with solid tumours discharged alive from the intensive care unit after unplanned admission: a retrospective study","volume":"57","author":"Borcoman","year":"2020","journal-title":"J Crit Care"},{"key":"2025110817253244500_dkaf335-B15","volume-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","author":"Rhodes","year":"2017"},{"key":"2025110817253244500_dkaf335-B16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2025110817253244500_dkaf335-B17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1469-0691.2007.01846.x","article-title":"Phenotypic detection of extended-spectrum \u03b2-lactamase production in Enterobacteriaceae: review and bench guide","volume":"14","author":"Drieux","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"2025110817253244500_dkaf335-B18","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1128\/JCM.00193-17","article-title":"Modified carbapenem inactivation method for phenotypic detection of carbapenemase production among Enterobacteriaceae","volume":"55","author":"Pierce","year":"2017","journal-title":"J Clin Microbiol"},{"key":"2025110817253244500_dkaf335-B19","doi-asserted-by":"publisher","first-page":"769","DOI":"10.21037\/atm-20-8216","article-title":"Carbapenemase detection by NG-test CARBA 5\u2014a rapid immunochromatographic assay in carbapenem-resistant Enterobacterales diagnosis","volume":"9","author":"Zhu","year":"2021","journal-title":"Ann Transl Med"},{"key":"2025110817253244500_dkaf335-B20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1080\/02841850410003671","article-title":"Complications associated with percutaneous nephrostomies. A retrospective study","volume":"45","author":"Radecka","year":"2004","journal-title":"Acta Radiol"},{"key":"2025110817253244500_dkaf335-B21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/bju.12918","article-title":"Retrograde ureteric stent insertion in the management of infected obstructed kidneys","volume":"115","author":"Flukes","year":"2015","journal-title":"BJU Int"},{"key":"2025110817253244500_dkaf335-B22","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/j.juro.2011.02.008","article-title":"Metal ureteral stent for benign and malignant ureteral obstruction","volume":"185","author":"Benson","year":"2011","journal-title":"J Urol"},{"key":"2025110817253244500_dkaf335-B23","doi-asserted-by":"publisher","first-page":"e0243474","DOI":"10.1371\/journal.pone.0243474","article-title":"Urinary tract infection in cancer patients and antimicrobial susceptibility of isolates in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia","volume":"15","author":"Sime","year":"2020","journal-title":"PLoS One"},{"key":"2025110817253244500_dkaf335-B24","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1016\/j.ijid.2012.11.030","article-title":"Enterobacteriaceae bacteremias among cancer patients: an observational cohort study","volume":"17","author":"Henao-Mart\u00ednez","year":"2013","journal-title":"Int J Infect Dis"},{"key":"2025110817253244500_dkaf335-B25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/03915603241236361","article-title":"Spectrum and antibiotic resistance in community- and hospital-acquired urinary tract infections among adults: experience from a large tertiary care center in a developing country","volume":"91","author":"Herbawi","year":"2024","journal-title":"Urologia"},{"key":"2025110817253244500_dkaf335-B26","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1017\/S0950268820003015","article-title":"Extended-spectrum beta-lactamase Escherichia coli and Klebsiella pneumoniae urinary tract infections","volume":"149","author":"Vachvanichsanong","year":"2020","journal-title":"Epidemiol Infect"},{"key":"2025110817253244500_dkaf335-B27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.idc.2013.10.002","article-title":"Management of urinary tract infections from multidrug-resistant organisms","volume":"28","author":"Gupta","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"2025110817253244500_dkaf335-B28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12879-023-08023-3","article-title":"Extended-spectrum beta-lactamase-producing Enterobacteriaceae related urinary tract infection in adult cancer patients: a multicenter retrospective study, 2015\u20132019","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Infect Dis"},{"key":"2025110817253244500_dkaf335-B29","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s00345-015-1718-x","article-title":"Extended-spectrum beta-lactamase-producing Enterobacteriaceae in hospital urinary tract infections: incidence and antibiotic susceptibility profile over 9 years","volume":"34","author":"Toner","year":"2016","journal-title":"World J Urol"},{"key":"2025110817253244500_dkaf335-B30","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.cmi.2017.03.026","article-title":"Risk factors for extended-spectrum \u03b2-lactamase-producing Escherichia coli urinary tract infection in the community in Denmark: a case\u2013control study","volume":"23","author":"S\u00f8gaard","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"2025110817253244500_dkaf335-B31","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.juro.2012.08.094","article-title":"Nephrostomy tube related pyelonephritis in patients with cancer: epidemiology, infection rate and risk factors","volume":"189","author":"Bahu","year":"2013","journal-title":"J Urol"},{"key":"2025110817253244500_dkaf335-B32","doi-asserted-by":"publisher","first-page":"e0022120","DOI":"10.1128\/cmr.00221-20","article-title":"Environmental, microbiological, and immunological features of bacterial biofilms associated with implanted medical devices","volume":"35","author":"Caldara","year":"2022","journal-title":"Clin Microbiol Rev"},{"key":"2025110817253244500_dkaf335-B33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s15010-018-1245-y","article-title":"Risk factors for recurrent percutaneous nephrostomy catheter-related infections","volume":"47","author":"Szvalb","year":"2019","journal-title":"Infection"},{"key":"2025110817253244500_dkaf335-B34","doi-asserted-by":"publisher","first-page":"e33002","DOI":"10.1097\/MD.0000000000033002","article-title":"Evaluation of risk factors, causative pathogens, and treatment in recurrent percutaneous nephrostomy catheter-related urinary tract infections in cancer patients","volume":"102","author":"Mert","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"2025110817253244500_dkaf335-B35","doi-asserted-by":"publisher","first-page":"e0237260","DOI":"10.1371\/journal.pone.0237260","article-title":"Relationship between the composition of the intestinal microbiota and the tracheal and intestinal colonization by opportunistic pathogens in intensive care patients","volume":"15","author":"Fontaine","year":"2020","journal-title":"PLoS One"},{"key":"2025110817253244500_dkaf335-B36","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.cmi.2022.01.004","article-title":"Changes in the gut microbiota and risk of colonization by multidrug-resistant bacteria, infection, and death in critical care patients","volume":"28","author":"Garcia","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"2025110817253244500_dkaf335-B37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10096-021-04289-0","article-title":"Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes","volume":"41","author":"Sokal","year":"2022","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2025110817253244500_dkaf335-B38","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jinf.2016.10.008","article-title":"Characteristics, aetiology, antimicrobial resistance and outcomes of bacteraemic cholangitis in patients with solid tumours: a prospective cohort study","volume":"74","author":"Royo-Cebrecos","year":"2017","journal-title":"J Infect"},{"key":"2025110817253244500_dkaf335-B39","doi-asserted-by":"publisher","first-page":"e0174421","DOI":"10.1128\/AAC.01744-21","article-title":"Impact of empirical antibiotic regimens on mortality in neutropenic patients with bloodstream infection presenting with septic shock","volume":"66","author":"Chumbita","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"2025110817253244500_dkaf335-B40","doi-asserted-by":"crossref","first-page":"e0213209","DOI":"10.1371\/journal.pone.0213209","article-title":"Time to initial cancer treatment in the United States and association with survival over time: an observational study","volume":"14","author":"Khorana","year":"2019","journal-title":"PLoS One"},{"key":"2025110817253244500_dkaf335-B41","doi-asserted-by":"crossref","first-page":"e107993","DOI":"10.1371\/journal.pone.0107993","article-title":"The impact of delayed chemotherapy on its completion and survival outcomes in stage II colon cancer patients","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/11\/3026\/64311413\/dkaf335.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/80\/11\/3026\/64311413\/dkaf335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:25:39Z","timestamp":1762640739000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/80\/11\/3026\/8257432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,9,18]]},"published-print":{"date-parts":[[2025,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaf335","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,9,18]]}}}