{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:07:20Z","timestamp":1792181240871,"version":"4.4.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020953","name":"Taiwan Centers for Disease Control","doi-asserted-by":"publisher","award":["MOHW113-CDC-C-114-000104"],"award-info":[{"award-number":["MOHW113-CDC-C-114-000104"]}],"id":[{"id":"10.13039\/100020953","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020953","name":"Taiwan Centers for Disease Control","doi-asserted-by":"publisher","award":["MOHW114-CDC-C-114-000101"],"award-info":[{"award-number":["MOHW114-CDC-C-114-000101"]}],"id":[{"id":"10.13039\/100020953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Doxycycline has demonstrated a favourable safety profile in clinical trials of post-exposure prophylaxis (doxy-PEP) for sexually transmitted infections; however, potential adverse effects may limit its feasibility. We aimed to investigate dermatological adverse effects of doxy-PEP in real-world settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre retrospective cohort study was conducted between October 2023 and February 2025, following the implementation of doxy-PEP among MSM. Individuals were encouraged to report adverse effects after initiating doxy-PEP. Data on medical history, previous therapeutic doxycycline exposure and history of allergic reactions were collected from electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 671 MSM were included, comprising 460 people with HIV and 211 on pre-exposure prophylaxis. Among them, nine individuals (1.3%) developed skin reactions, with an incidence rate of 1.0 per 100 person-years. Most were fixed drug eruptions (n\u200a=\u200a8), with one case of photosensitivity. These reactions typically appeared within 24\u2005h of exposure; and all nine individuals discontinued doxy-PEP, and symptoms resolved within 1\u20133\u2005weeks. Individuals with a prior history of allergic reactions to any medication were at greater risk of experiencing adverse skin reactions (odds ratio, 6.99; 95% CI, 1.83\u201326.65). Notably, all individuals who experienced dermatological adverse events had previously used therapeutic doxycycline, though only three reported prior allergic reactions to it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although dermatological adverse events associated with doxy-PEP were generally mild, they led to discontinuations. These findings underscore the importance of obtaining a thorough history of drug allergy before initiating doxy-PEP and highlight the need for vigilant monitoring of dermatological adverse events during its use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf351","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T11:59:45Z","timestamp":1757073585000},"page":"3118-3122","source":"Crossref","is-referenced-by-count":3,"title":["Dermatological adverse effects of doxycycline as post-exposure prophylaxis for sexually transmitted infections among men who have sex with men: real-world findings from a multicentre study"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-6595","authenticated-orcid":false,"given":"Ling-Ya","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Infection Control, National Taiwan University Hospital , Taipei 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,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Da","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Taiwan University Cancer Centre , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-5709","authenticated-orcid":false,"given":"Yu-Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , 7 Chung-Shan South Road, Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , 7 Chung-Shan South Road, Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristine","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , 7 Chung-Shan South Road, Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhen","family":"Luo","sequence":"additional","affiliation":[{"name":"Center for Infection Control, National Taiwan University Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Infection Control, National Taiwan University Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Yen","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Infection Control, National Taiwan University 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