{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:56:35Z","timestamp":1793055395572,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020278","name":"EU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NextGenerationEU-MUR PNRR Extended Partnership","award":["PE0000000"],"award-info":[{"award-number":["PE0000000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Bloodstream infections (BSIs) caused by carbapenemase-resistant Klebsiella pneumoniae (CR-Kp) are associated with high morbidity and mortality, particularly in frail patients. Identifying frailty upon hospital admission may improve clinical decision-making and outcomes. This study evaluates the Frailty Index Laboratory (FI-Lab) as a predictive tool for adverse outcomes in patients with CR-Kp BSIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted between January 2020 and September 2024 at the Policlinico Universitario di Bari. Frailty was assessed using FI-Lab, derived from 35 laboratory parameters measured within 96\u2005h of admission. Outcomes included all-cause mortality, 28\u2005day mortality and relapse, with FI-Lab predictive accuracy evaluated via ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 182 patients with CR-Kp BSIs were included, of whom 48 died (26.3%). Non-survivors had significantly higher FI-Lab scores than survivors (0.66\u200a\u00b1\u200a0.10 versus 0.33\u200a\u00b1\u200a0.16, P\u200a&amp;lt;\u200a0.0001). FI-Lab demonstrated excellent predictive accuracy for mortality (AUC\u200a=\u200a0.94), 28\u2005day mortality (AUC\u200a=\u200a0.87) and relapse (AUC\u200a=\u200a0.87). Each 0.10-point increase in FI-Lab was associated with a higher risk of mortality (HR\u200a=\u200a2.07), 28\u2005day mortality (HR\u200a=\u200a1.86) and relapse (HR\u200a=\u200a1.52).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FI-Lab proved to be a simple and robust tool for early frailty assessment in patients with CR-Kp BSIs. Further studies are needed to validate these findings and explore the broader applicability of FI-Lab in managing infections in vulnerable populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf359","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:43:16Z","timestamp":1757763796000},"page":"3257-3264","source":"Crossref","is-referenced-by-count":2,"title":["Frailty Index Laboratory (FI-Lab) as predictor of poor outcomes for intra-hospital multidrug-resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    bloodstream infections: a single-centre retrospective cohort study"],"prefix":"10.1093","volume":"80","author":[{"given":"Carmen","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro , Bari 70124 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