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Clinical efficacy was evaluated by measuring the size of the lesion and parasitological efficacy by limited dilution assay of the parasite culture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PA showed a tendency to reduce the size of the lesion, but without a significant difference in relation to the control. AmphLipo reduced the parasite load in the spleen (P\u200a&amp;lt;\u200a0.05), but there was no difference in the size of the lesion between the treated groups and the control group. Glu IL showed complete epithelialization in 80% (weekly) and 100% (fortnightly) of the animals (P\u200a&amp;lt;\u200a0.05) but did not reduce the parasite load. Instead, all binary combinations (PA\u200a+\u200aGluIL, PA\u200a+\u200aAmphLipo and GluIL\u200a+\u200aAmphLipo) reduced the size of the lesions by 100% (P\u200a&amp;lt;\u200a0.05). No animal showed weight loss or toxic effects, such as ruffled fur, aggressiveness, diarrhoea or other adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combinations tested were more effective in healing the lesions than the monotherapies, representing a promising alternative for the treatment of cutaneous leishmaniasis and encouraging new clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf362","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:54:32Z","timestamp":1757505272000},"page":"3278-3287","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by\n                    <i>Leishmania<\/i>\n                    (\n                    <i>Viannia<\/i>\n                    )\n                    <i>braziliensis<\/i>"],"prefix":"10.1093","volume":"80","author":[{"given":"L\u00edndicy Leidicy","family":"Alves","sequence":"first","affiliation":[{"name":"Clinical Research and Public Policy Group on Infectious and Parasitic Diseases\u2014Ren\u00e9 Rachou Institute\u2014Funda\u00e7\u00e3o Oswaldo Cruz\u2014FIOCRUZ , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian Carlo","family":"Pinheiro Rosa","sequence":"additional","affiliation":[{"name":"Clinical Research and Public Policy Group on Infectious and Parasitic Diseases\u2014Ren\u00e9 Rachou Institute\u2014Funda\u00e7\u00e3o Oswaldo Cruz\u2014FIOCRUZ , Belo Horizonte, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Louren\u00e7o","family":"Freire","sequence":"additional","affiliation":[{"name":"Clinical Research and Public 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