{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:48:19Z","timestamp":1780408099984,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the epidemiology and outcomes of patients with non-Serratia Enterobacterales endocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients were identified at 14 hospitals between January 2000 and December 2024 with definite non-Serratia Enterobacterales endocarditis. Combination therapy was defined as receipt of \u22652 antimicrobial agents with documented in vitro activity against the primary pathogen for \u226572\u2005hours. Clinical failure was defined as a composite of all-cause 42-day mortality or treatment-emergent resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-five patients were included. The median (IQR) age was 67 (51\u201378) years, and 16% (12\/75) were patients who inject drugs. The most common pathogens were E. coli [41% (31\/75)] and Klebsiella spp. [37% (28\/75)]. Klebsiella spp. were most commonly associated with septic emboli. Patients who experienced clinical failure were more likely to have a higher median (IQR) age [71 (66\u201379) versus 62 (43\u201376); P\u200a=\u200a0.031], higher median (IQR) Charlson comorbidity index [4 (2\u20137) versus 3 (1\u20134); P\u200a=\u200a0.026] and were less likely to receive surgery despite an indication [59% (10\/17) versus 21% (10\/47); P\u200a=\u200a0.007]. After propensity score weighting, patients with valvular endocarditis treated with a combination regimen had a trend towards a lower 90-day mortality (HR\u200a=\u200a0.39; 95% CI: 0.13\u20131.19; P\u200a=\u200a0.098). However, patients who received combination therapy also had a proportionally higher rate of adverse events [33% (7\/21) versus 13% (7\/47); P\u200a=\u200a0.054].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of combination treatment may improve mortality in patients with non-Serratia Enterobacterales endocarditis; however, larger studies are required. Adverse effects among patients who received combination therapy were common.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf432","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:04:50Z","timestamp":1762434290000},"source":"Crossref","is-referenced-by-count":3,"title":["Epidemiology and treatment of endocarditis secondary to Enterobacterales other than\n                    <i>Serratia<\/i>\n                    spp."],"prefix":"10.1093","volume":"81","author":[{"given":"Clayton F","family":"Hausberger","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pittsburgh Medical Center , Falk Medical Building, Suite 3A, Room 317, 3601 Fifth Avenue, Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, University of Pittsburgh , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G K","family":"Balasubramani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-5665","authenticated-orcid":false,"given":"Ryan K","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh Medical Center , Pittsburgh, PA ,","place":["USA"]},{"name":"Antibiotic Management Program, University of Pittsburgh Medical Center , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-1451","authenticated-orcid":false,"given":"Sunish","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pittsburgh Medical Center , Falk Medical 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