{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:00:29Z","timestamp":1768456829096,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20338"],"award-info":[{"award-number":["U22A20338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402677"],"award-info":[{"award-number":["82402677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270183"],"award-info":[{"award-number":["32270183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ24H200005"],"award-info":[{"award-number":["LQ24H200005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the genomic and resistance features of a blaNDM-1-positive Acinetobacter soli isolate and assess the global distribution and genomic traits of A. soli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We isolated a blaNDM-1-positive A. soli strain from a patient in 2023. Antimicrobial susceptibility testing was performed and whole-genome sequencing was used to investigate the genomic characteristics and resistance features of A. soli. Conjugation was performed to assess the transferability of the blaNDM-1-carrying plasmid, and plasmid stability was evaluated using serial-passaging experiments. Additionally, genomic analysis of 74 publicly available A. soli genomes was performed to explore their global distribution, resistance genes, plasmid replicons and phylogeographic relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SZL7 exhibited resistance to meropenem (8\u2005mg\/L) and ceftazidime (\u226564\u2005mg\/L), but remained susceptible to tigecycline, polymyxin B, fluoroquinolones, cefiderocol and cefoperazone-sulbactam. Among the 74 global genomes, blaNDM-1 was detected in 9.46% (7\/74) of the isolates. The blaNDM-1 gene was located on a plasmid and was stably inherited after 10\u2005days of serial passage. A total of 83.78% of the isolates originated from Asia, particularly China and Japan. Notably, all Chinese isolates were collected from coastal cities, with environmental samples predominating, indicating the importance of environmental monitoring in these high-risk areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents the first global genomic analysis of A. soli, highlighting its potential as a reservoir and vector for clinically significant resistance genes, such as blaNDM-1. These findings emphasize the importance of continuous genomic surveillance and environmental monitoring within the One Health framework to mitigate emerging resistance threats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf437","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:59:35Z","timestamp":1762952375000},"source":"Crossref","is-referenced-by-count":0,"title":["Global phylogeography and genomic characterization of\n                    <i>bla<\/i>\n                    NDM-1-positive carbapenem-resistant\n                    <i>Acinetobacter soli<\/i>"],"prefix":"10.1093","volume":"81","author":[{"given":"Pengpeng","family":"Min","sequence":"first","affiliation":[{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College , Hangzhou, Zhejiang 310014 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Hangzhou, Zhejiang 310014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8215-916X","authenticated-orcid":false,"given":"Xiaoting","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College , Hangzhou, Zhejiang 310014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meizhen","family":"Ye","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College , Hangzhou, Zhejiang ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-918X","authenticated-orcid":false,"given":"Yunsong","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College , Hangzhou, Zhejiang 310014 ,","place":["China"]},{"name":"Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College , Hangzhou, Zhejiang 310014 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