{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:06:27Z","timestamp":1768907187269,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ototoxic potential of aminoglycosides has limited their use. Although their effects on adult hearing have been extensively studied, there is limited research on their potential effects on newborns following intrauterine exposure. However, aminoglycosides are commonly used to treat urinary tract infections during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives and methods<\/jats:title>\n                    <jats:p>Evaluate the incidence of sensorineural hearing loss (SNHL) in neonates who were exposed to aminoglycosides in utero. A cohort of children born between 2018 and 2024 at a single urban hospital was analysed; all underwent universal hearing screening and, if necessary, a complete diagnostic audiological evaluation. Hearing test results of newborns whose mothers were exposed to aminoglycosides in utero were compared with those of unexposed newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 39\u200a237 newborns were included in the study. Of these, 85 were exposed in utero to aminoglycosides: gentamicin (13, 34 and 33 in first, second and third trimesters, respectively) or amikacin (3 and 4 in second and third trimesters, respectively), for a mean of three doses. Exposed children had significantly higher rates of other risk factors for hearing loss, including prolonged ICU stay, low birth weight and a family history of hearing loss. However, no exposed newborns developed SNHL, compared to 100 unexposed newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Among 85 children exposed to aminoglycosides in utero, mostly to gentamicin, no cases of congenital SNHL were observed, despite the higher prevalence of other risk factors. Although limited by a relatively small number of aminoglycoside exposures, these findings suggest that short courses of aminoglycosides during pregnancy are not likely to be associated with increased risk of congenital SNHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaf483","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:43:06Z","timestamp":1765888986000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of intrauterine exposure to aminoglycosides on neonatal hearing"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-3208","authenticated-orcid":false,"given":"Daniel","family":"Leshin-Carmel","sequence":"first","affiliation":[{"name":"Infectious Diseases and Infection Control Unit, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Kariv","sequence":"additional","affiliation":[{"name":"Department of Communication Disorders, Ariel University , Ariel ,","place":["Israel"]},{"name":"Hearing and Speech Institute, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Mor","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Unit, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ortal","family":"Neeman","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta Benshalom","family":"Tirosh","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Brosh-Nissimov","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Infection Control Unit, Samson Assuta Ashdod Hospital , Ashdod ,","place":["Israel"]},{"name":"Faculty of Health Sciences, Ben Gurion University in the Negev , Be\u2019er Sheva ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"2026011902093549700_dkaf483-B1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2174\/138161207779313731","article-title":"Aminoglycoside-induced ototoxicity","volume":"13","author":"Selimoglu","year":"2007","journal-title":"Curr Pharm Des"},{"key":"2026011902093549700_dkaf483-B2","doi-asserted-by":"publisher","first-page":"937861","DOI":"10.1155\/2011\/937861","article-title":"Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection","author":"Huth","year":"2011","journal-title":"Int J Otolaryngol"},{"key":"2026011902093549700_dkaf483-B3","doi-asserted-by":"publisher","first-page":"905","DOI":"10.22037\/ijpr.2011.979","article-title":"The incidence of Amikacin ototoxicity in multidrug resistant tuberculosis patients","volume":"10","author":"Javadi","year":"2011","journal-title":"Iran J Pharm Res"},{"key":"2026011902093549700_dkaf483-B4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jinf.2021.05.010","article-title":"Prevalence of aminoglycosides induced hearing loss in drug resistant tuberculosis patient: a systematic review","volume":"83","author":"Dillard","year":"2021","journal-title":"J Infect"},{"key":"2026011902093549700_dkaf483-B5","first-page":"201","article-title":"Intrauterine ototoxicity. 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