{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:22:32Z","timestamp":1774725752654,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University Hospital of Poitiers","award":["INSERM U1070"],"award-info":[{"award-number":["INSERM U1070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Surgical site infections (SSIs) are a leading cause of healthcare-associated infections, particularly in abdominal surgery. In patients allergic to beta-lactams, gentamicin is often used for surgical antibiotic prophylaxis (SAP), but its efficacy is questioned due to limited tissue-level pharmacokinetic\/pharmacodynamic (PK\/PD) data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a monocentric prospective study involving eight adult patients undergoing major abdominal surgery who received gentamicin (5\u2005mg\/kg IV) for SAP. Subcutaneous unbound gentamicin concentrations were measured using microdialysis over 6 h. Plasma and tissue PKs were analysed using nonlinear mixed-effects modelling. Monte Carlo simulations assessed the probability of target attainment (PTA) for Cmax\/MIC &amp;gt;8 at doses of 5 and 8\u2005mg\/kg, using EUCAST MIC distributions for Escherichia coli and Staphylococcus aureus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 246 samples were collected (100 plasma and 146 microdialysate). Subcutaneous gentamicin concentrations were lower than plasma concentrations throughout the 0\u20136\u2005h interval. Mean Cmax values were 43.7\u200a\u00b1\u200a4.5\u2005mg\/L in plasma and 17.8\u200a\u00b1\u200a11.5\u2005mg\/L in subcutaneous tissue. Given the lack of defined tissue PK\/PD targets in surgical prophylaxis, a plasma-based Cmax\/MIC\u200a&amp;gt;\u200a8 target was used for PTA simulations. At 5\u2005mg\/kg, PTA was suboptimal for MIC \u22651\u2005mg\/L in subcutaneous tissue. Simulations showed that increasing the dose to 8\u2005mg\/kg improved the cumulative fraction of response against E. coli and S. aureus from 70% and 79% to 80% and 87%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study highlights insufficient subcutaneous gentamicin exposure with standard SAP dosing. An 8\u2005mg\/kg dose improved tissue PK\/PD target attainment, supporting updated dosing recommendations for beta-lactam-allergic patients. Further research is needed to validate safety and efficacy in broader populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag071","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:22:50Z","timestamp":1771244570000},"source":"Crossref","is-referenced-by-count":1,"title":["Microdialysis assessment of gentamicin for second-line antimicrobial prophylaxis in abdominal surgery"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6420-0480","authenticated-orcid":false,"given":"Quentin","family":"Saint-Genis","sequence":"first","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]},{"name":"Service d\u2019anesth\u00e9sie-R\u00e9animation et M\u00e9decine P\u00e9ri-Op\u00e9ratoire, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Marchand","sequence":"additional","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]},{"name":"Service de Toxicologie-Pharmacocin\u00e9tique, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-5888","authenticated-orcid":false,"given":"Alexia","family":"Chauzy","sequence":"additional","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Mirfendereski","sequence":"additional","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kostencovska","sequence":"additional","affiliation":[{"name":"Service d\u2019anesth\u00e9sie-R\u00e9animation et M\u00e9decine P\u00e9ri-Op\u00e9ratoire, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Service d\u2019anesth\u00e9sie-R\u00e9animation et M\u00e9decine P\u00e9ri-Op\u00e9ratoire, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Gregoire","sequence":"additional","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]},{"name":"Service de Toxicologie-Pharmacocin\u00e9tique, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-5782","authenticated-orcid":false,"given":"Matthieu","family":"Boisson","sequence":"additional","affiliation":[{"name":"INSERM U1070, PHAR2, Universit\u00e9 de Poitiers , Poitiers ,","place":["France"]},{"name":"Service d\u2019anesth\u00e9sie-R\u00e9animation et M\u00e9decine P\u00e9ri-Op\u00e9ratoire, CHU de Poitiers , Poitiers ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026022604254510700_dkag071-B1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.anrea.2021.04.010","article-title":"Pr\u00e9vention du risque infectieux p\u00e9riop\u00e9ratoire","volume":"7","author":"Boisson","year":"2021","journal-title":"Anesth R\u00e9anim"},{"key":"2026022604254510700_dkag071-B2","author":"European Centre for Disease Prevention and Control.","year":"2022"},{"key":"2026022604254510700_dkag071-B3","volume-title":"Global Guidelines for the Prevention of Surgical Site Infection","author":"World Health Organization","year":"2016"},{"key":"2026022604254510700_dkag071-B4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am J Health Syst Pharm"},{"key":"2026022604254510700_dkag071-B5","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.accpm.2019.02.017","article-title":"Antibioprophylaxis in surgery and interventional medicine (adult patients). 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