{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:05:36Z","timestamp":1789506336360,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"ViiV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the prevalence of transmitted drug resistance mutations (TDRMs) and the impact of pre-existing resistance mutations, including minority variants, on virological response in ART-na\u00efve individuals initiating dolutegravir-based triple therapy using next-generation sequencing (GRT-NGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentre, retrospective cohort study was conducted including ART-na\u00efve individuals who started a dolutegravir-3DR between 2015 and 2019. Baseline GRT-NGS Illumina\u00ae, covering RT, PR and IN genes identified primary (P-DRM) and secondary\/polymorphic (S\/p-DRM) mutations in high-abundance drug resistance variants (HA-DRVs; \u226520%) and low-abundance drug resistance variants (LA-DRVs; 1%\u201319%). Virological failure (VF) was defined as two consecutive HIV-1 RNA\u200a\u2265\u200a50\u2005copies\/mL. Virological response was assessed at Weeks 48 and 96.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 326 participants, 86% were male and 72% were MSM; 78% received DTG\/ABC\/3TC and 22% TDF\/FTC\u200a+\u200aDTG. At least one TDRM was detected in 24% and any DRM in 48% of subjects. Virological suppression was achieved in 76% by intention-to-treat (ITT), 97% on-treatment (OT) and 56% (ITT), 94% (ITT) at Weeks 48 and 96, respectively. VF occurred in 11 subjects (3.4%), mostly within 48\u2005weeks, all with low-level viraemia (&amp;lt;1000\u2005copies\/mL; 8\u200a&amp;lt;\u200a200\u2005copies\/mL) and no emergent of new DRM in HA-DRVs with phenotypic impact. Among those with pre-existing DRM, including 36 P-HA-DRVs, 79 S\/p-HA-DRVs, 57 P-LA-DRVs and 45 S\/P-LA-DRVs, no significant association with VF was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that pre-existing IN and RT DRM, including low-abundance and secondary\/polymorphic variants, did not compromise the virological efficacy of dolutegravir-based triple therapy in ART-na\u00efve individuals, supporting the high resistance barrier of dolutegravir and the lack of need for baseline resistance testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag080","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:12:21Z","timestamp":1774332741000},"source":"Crossref","is-referenced-by-count":1,"title":["Baseline resistance mutations and virological response to dolutegravir in 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