{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:49:50Z","timestamp":1777564190004,"version":"3.51.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100008269","name":"L\u00e6ge Sofus Carl Emil Friis og Hustru Olga Doris Friis\u2019 Legat foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009584","name":"The Toyota Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009908","name":"Grosserer L.F. Foghts foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perioperative antibiotic prophylaxis is essential in oral cancer surgery to prevent surgical site infections, particularly when regional flaps such as the facial artery musculomucosal (FAMM) flap are used. This study compared free cefuroxime concentrations in plasma, FAMM flap, buccal submucosa and subcutaneous tissue following bolus infusion (BI) versus continuous infusion (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen patients scheduled for tumour resection and FAMM flap reconstruction were randomized to receive cefuroxime either as BI (1500\u2005mg every 8\u2005h) (Group BI) or CI (4500\u2005mg\/day) (Group CI). Microdialysis catheters were placed in the FAMM flap, buccal submucosa and subcutaneous tissue in the neck. Free cefuroxime concentrations were measured over 8\u2005h. The primary endpoints were time with concentrations above the minimal inhibitory concentration (T &amp;gt; MIC) and attainment of the treatment target 50%T &amp;gt; MIC for MIC 2 and 4\u2005mg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients achieved \u226550%T &amp;gt; MIC in all tissues for both MIC targets. Group CI achieved 100%T &amp;gt; MIC across all compartments and both MIC thresholds, whereas the mean T &amp;gt; MIC in Group BI were in the range 89%\u201398% for MIC 2\u2005mg\/L and 79%\u201390% for MIC 4\u2005mg\/L. Group CI achieved significantly higher T &amp;gt; MIC than Group BI in subcutaneous tissue for both MIC thresholds and in plasma for MIC 4\u2005mg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A daily dose of 4500\u2005mg cefuroxime provides adequate tissue and plasma concentrations with both BI and CI to achieve \u226550%T &amp;gt; MIC in patients undergoing oral cavity cancer surgery with FAMM flap reconstruction. CI provided more consistent exposure and may offer pharmacokinetic advantages in selected high-risk situations\/patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag085","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:33:26Z","timestamp":1771936406000},"source":"Crossref","is-referenced-by-count":1,"title":["Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study"],"prefix":"10.1093","volume":"81","author":[{"given":"Johanne Ravn","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, Aarhus N 8200 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aarhus University, FORUM , Palle Juul-Jensens 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