{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:03:34Z","timestamp":1773270214846,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100018853","name":"Prince Charles Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031173","name":"Australian and New Zealand Intensive Care Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001136","name":"Australian and New Zealand College of Anaesthetists","doi-asserted-by":"publisher","award":["S12\/001"],"award-info":[{"award-number":["S12\/001"]}],"id":[{"id":"10.13039\/501100001136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001136","name":"Australian and New Zealand College of Anaesthetists","doi-asserted-by":"publisher","award":["S13\/021"],"award-info":[{"award-number":["S13\/021"]}],"id":[{"id":"10.13039\/501100001136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001238","name":"Society of Hospital Pharmacists of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1079421"],"award-info":[{"award-number":["APP1079421"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1099452"],"award-info":[{"award-number":["APP1099452"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe meropenem population pharmacokinetics in critically ill adults receiving extracorporeal membrane oxygenation (ECMO) with or without renal replacement therapy (RRT), and to identify dosing regimens likely to achieve safe and effective exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serial blood samples were collected over a single dosing interval during ECMO. Total plasma concentrations were measured by a validated assay. Population pharmacokinetic modelling and Monte Carlo dosing simulations were performed using Monolix. Dosing regimens were assessed against efficacy targets (Cmin \u22652 or \u22658\u2005mg\/L) and a toxicity threshold (Cmin &amp;gt;45\u2005mg\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 150 plasma concentration-time points were obtained from 18 patients. Meropenem pharmacokinetics were best described by a two-compartment model with first-order elimination. ECMO flow rate significantly influenced the volume of distribution of the central compartment, while estimated creatinine clearance and concomitant RRT significantly influenced drug clearance. Using the primary efficacy target of 2\u2005mg\/L, a meropenem dose of 1\u2005g every 8\u2005h as continuous infusion was the most appropriate regimen for patients with a creatinine clearance of 60\u2013130\u2005mL\/min receiving ECMO at a flow rate of 4\u20136\u2005L\/min. In patients receiving RRT, this regimen demonstrated less than 4% probability of reaching toxic concentrations and 100% probability of achieving the efficacy target across all simulated scenarios. The regimen remained robust against the higher efficacy target of 8\u2005mg\/L in most scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A meropenem dose of 1\u2005g every 8\u2005h as continuous infusion is safe and efficacious in most critically ill patients receiving ECMO with or without concomitant RRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag090","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:43:54Z","timestamp":1771937034000},"source":"Crossref","is-referenced-by-count":0,"title":["Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation\u2014an ASAP ECMO study"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-5579","authenticated-orcid":false,"given":"Mohd H","family":"Abdul\u2013Aziz","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesa","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fay","family":"Burrows","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, St.Vincent\u2019s Hospital , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hergen","family":"Buscher","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, St.Vincent\u2019s Hospital , Sydney, New South Wales ,","place":["Australia"]},{"name":"St Vincent\u2019s Centre for Applied Medical Research, University of New South Wales , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seongnam ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Corley","sequence":"additional","affiliation":[{"name":"Critical Care Research Group and Adult Intensive Care Services and Critical Care Research Group, The Prince Charles Hospital , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Diehl","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, Victoria, Australia and School of Public Health and Preventive Medicine, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Gilder","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital , Auckland ,","place":["New Zealand"]},{"name":"School of Nursing, The University of Auckland , Auckland ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Seoul National University Bundang Hospital , Seongnam ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca J","family":"Levkovich","sequence":"additional","affiliation":[{"name":"Experiential Development and Graduate Education and Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yoon","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seongnam ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"McGuinness","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital , Auckland ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Ordonez","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Parke","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital , Auckland ,","place":["New Zealand"]},{"name":"School of Nursing, The University of Auckland , Auckland ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, Victoria, Australia and School of Public Health and Preventive Medicine, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, St.Vincent\u2019s Hospital , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Rudham","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, St.Vincent\u2019s Hospital , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-9854","authenticated-orcid":false,"given":"Steven C","family":"Wallis","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, St.Vincent\u2019s Hospital , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F","family":"Fraser","sequence":"additional","affiliation":[{"name":"Critical Care Research Group and Adult Intensive Care Services and Critical Care Research Group, The Prince Charles Hospital , Brisbane, Queensland ,","place":["Australia"]},{"name":"Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]},{"name":"Faculty of Health, Queensland University of Technology , Brisbane, Queensland ,","place":["Australia"]},{"name":"Faculty of Health Sciences and Medicine, Bond University , Gold Coast, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Shekar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]},{"name":"Faculty of Health, Queensland University of Technology , Brisbane, Queensland ,","place":["Australia"]},{"name":"Faculty of Health Sciences and Medicine, Bond University , Gold Coast, Queensland ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland , Brisbane, Queensland ,","place":["Australia"]},{"name":"Metro North Health, Herston Infectious Diseases Institute (HeIDI) , Brisbane, Queensland ,","place":["Australia"]},{"name":"Department of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women\u2019s Hospital , Brisbane, Queensland ,","place":["Australia"]},{"name":"Division of Anaesthesiology Critical Care Emergency and Pain Medicine, N\u00eemes University Hospital, University of Montpellier , N\u00eemes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"2026031103461583400_dkag090-B1","doi-asserted-by":"publisher","first-page":"R206","DOI":"10.1186\/cc10441","article-title":"Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of \u03b2-lactams","volume":"15","author":"Gon\u00e7alves-Pereira","year":"2011","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B2","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1093\/cid\/ciu027","article-title":"DALI: defining antibiotic levels in intensive care unit patients: are current beta-lactam antibiotic doses sufficient for critically ill patients?","volume":"58","author":"Roberts","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2026031103461583400_dkag090-B3","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1093\/cid\/ciaa224","article-title":"The effect of renal replacement therapy and antibiotic dose on antibiotic concentrations in critically ill patients: data from the multinational sampling antibiotics in renal replacement therapy study","volume":"72","author":"Roberts","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2026031103461583400_dkag090-B4","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1007\/s00134-022-06847-2","article-title":"Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software","volume":"48","author":"Roberts","year":"2022","journal-title":"Intensive Care Med"},{"key":"2026031103461583400_dkag090-B5","doi-asserted-by":"publisher","first-page":"e02390","DOI":"10.1128\/AAC.02390-17","article-title":"Population pharmacokinetics of Meropenem in plasma and subcutis from patients on extracorporeal membrane oxygenation treatment","volume":"62","author":"Hanberg","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2026031103461583400_dkag090-B6","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/microorganisms9061310","article-title":"Meropenem pharmacokinetics and target attainment in critically ill patients are not affected by extracorporeal membrane oxygenation: a matched cohort analysis","volume":"9","author":"Gijsen","year":"2021","journal-title":"Microorganisms"},{"key":"2026031103461583400_dkag090-B7","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.3390\/pharmaceutics13111861","article-title":"Population Pharmacokinetics of meropenem in critically ill Korean patients and effects of extracorporeal membrane Oxygenation","volume":"13","author":"Lee","year":"2021","journal-title":"Pharmaceutics"},{"key":"2026031103461583400_dkag090-B8","doi-asserted-by":"publisher","first-page":"768912","DOI":"10.3389\/fphar.2021.768912","article-title":"Pharmacokinetics and Monte Carlo simulation of Meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation","volume":"12","author":"Lee","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026031103461583400_dkag090-B9","doi-asserted-by":"publisher","first-page":"6621","DOI":"10.3390\/jcm11226621","article-title":"Dose optimization of Meropenem in patients on veno-arterial extracorporeal membrane oxygenation in critically ill cardiac patients: pharmacokinetic\/pharmacodynamic modeling","volume":"11","author":"Kang","year":"2022","journal-title":"J Clin Med"},{"key":"2026031103461583400_dkag090-B10","first-page":"497","article-title":"Elevated beta-lactam concentrations associated with neurological deterioration in ICU septic patients","volume":"81","author":"Beumier","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"2026031103461583400_dkag090-B11","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1093\/jac\/dkx209","article-title":"Too much of a good thing: a retrospective study of beta-lactam concentration-toxicity relationships","volume":"72","author":"Imani","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2026031103461583400_dkag090-B12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2253-12-29","article-title":"ASAP ECMO: antibiotic, sedative and analgesic Pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO","volume":"12","author":"Shekar","year":"2012","journal-title":"BMC Anesthesiol"},{"key":"2026031103461583400_dkag090-B13","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1164\/rccm.202207-1393OC","article-title":"Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation","volume":"207","author":"Shekar","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031103461583400_dkag090-B14","author":"Food and Drug Administration"},{"key":"2026031103461583400_dkag090-B15","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med"},{"key":"2026031103461583400_dkag090-B16","unstructured":"The European Committee on Antimicrobial Susceptibility Testing\n          . Breakpoint tables for interpretation of MICs and zone diameters. version 15.0. 2025."},{"key":"2026031103461583400_dkag090-B17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13054-019-2378-9","article-title":"Optimization of the treatment with beta-lactam antibiotics in critically ill patients-guidelines from the French society of pharmacology and therapeutics (Soci\u00e9t\u00e9 Fran\u00e7aise de Pharmacologie et Th\u00e9rapeutique-SFPT) and the French society of anaesthesia and intensive care medicine (Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et R\u00e9animation-SFAR)","volume":"23","author":"Guilhaumou","year":"2019","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13054-024-04911-5","article-title":"Impact of attaining aggressive vs. Conservative PK\/PD target on the clinical efficacy of beta-lactams for the treatment of gram-negative infections in the critically ill patients: a systematic review and meta-analysis","volume":"28","author":"Gatti","year":"2024","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1186\/s13054-014-0565-2","article-title":"The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study","volume":"18","author":"Shekar","year":"2014","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B20","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ijantimicag.2014.11.005","article-title":"beta-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: a case-control study","volume":"45","author":"Donadello","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"2026031103461583400_dkag090-B21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.accpm.2019.02.015","article-title":"PHARMECMO: therapeutic drug monitoring and adequacy of current dosing regimens of antibiotics in patients on extracorporeal life support","volume":"38","author":"Bougle","year":"2019","journal-title":"Anaesth Crit Care Pain Med"},{"key":"2026031103461583400_dkag090-B22","doi-asserted-by":"publisher","first-page":"R194","DOI":"10.1186\/cc11679","article-title":"Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation","volume":"16","author":"Shekar","year":"2012","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13054-015-0891-z","article-title":"Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study","volume":"19","author":"Shekar","year":"2015","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/s13054-015-1151-y","article-title":"Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models","volume":"19","author":"Shekar","year":"2015","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B25","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1177\/02676591211018985","article-title":"Oxygenator impact on meropenem\/vaborbactam in extracorporeal membrane oxygenation circuits","volume":"37","author":"Cies","year":"2022","journal-title":"Perfusion"},{"key":"2026031103461583400_dkag090-B26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1051\/ject\/2023035","article-title":"Meropenem extraction by ex vivo extracorporeal life support circuits","volume":"55","author":"Honeycutt","year":"2023","journal-title":"J Extra Corpor Technol"},{"key":"2026031103461583400_dkag090-B27","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1186\/s13054-020-03397-1","article-title":"Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study","volume":"24","author":"K\u00fchn","year":"2020","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B28","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/cid\/ciy790","article-title":"Renal dosing of antibiotics: are we jumping the gun?","volume":"68","author":"Crass","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2026031103461583400_dkag090-B29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13054-025-05736-6","article-title":"Beta-lactam dose reductions in critically ill patients with acute kidney injury: a scoping review","volume":"30","author":"Horstink","year":"2025","journal-title":"Crit Care"},{"key":"2026031103461583400_dkag090-B30","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"2026031103461583400_dkag090-B31","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/phar.2842","article-title":"International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: endorsed by the American college of clinical pharmacy, British Society for Antimicrobial Chemotherapy, cystic fibrosis foundation, European society of clinical microbiology and infectious diseases, Infectious Diseases Society of America, society of critical care medicine, and society of infectious diseases pharmacists","volume":"43","author":"Hong","year":"2023","journal-title":"Pharmacotherapy"},{"key":"2026031103461583400_dkag090-B32","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1001\/jama.2024.9779","article-title":"Continuous vs intermittent \u03b2-Lactam antibiotic infusions in critically ill patients with sepsis: the BLING III randomized clinical trial","volume":"332","author":"Dulhunty","year":"2024","journal-title":"JAMA"},{"key":"2026031103461583400_dkag090-B33","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1001\/jama.2024.9803","article-title":"Prolonged vs intermittent infusions of \u03b2-Lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis","volume":"332","author":"Abdul-Aziz","year":"2024","journal-title":"JAMA"},{"key":"2026031103461583400_dkag090-B34","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1007\/s00134-024-07650-x","article-title":"Continuous infusion of beta-lactam antibiotics in critically ill patients with sepsis: implementation considerations","volume":"50","author":"Barton","year":"2024","journal-title":"Intensive Care Med"},{"key":"2026031103461583400_dkag090-B35","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1007\/s00134-025-08067-w","article-title":"Meropenem and piperacillin\/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy","volume":"51","author":"Roberts","year":"2025","journal-title":"Intensive Care Med"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/81\/4\/dkag090\/67296720\/dkag090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/81\/4\/dkag090\/67296720\/dkag090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:46:27Z","timestamp":1773215187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/doi\/10.1093\/jac\/dkag090\/8513779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkag090","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,4]]},"article-number":"dkag090"}}