{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:40:26Z","timestamp":1776847226478,"version":"3.51.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pla estrat\u00e8gic de recerca i innovaci\u00f3 en salut"},{"DOI":"10.13039\/501100022335","name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RICAI International Mobility"},{"name":"Rennes University Hospital International Mobility"},{"name":"Coll\u00e8ge Doctoral de Bretagne Outgoing International Mobility Programme"},{"DOI":"10.13039\/100030956","name":"Fundaci\u00f3 Cl\u00ednic per a la Recerca Biom\u00e8dica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031015","name":"Hospital Cl\u00ednic de Barcelona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Effective alternatives to standard of care treatment for E. faecalis infective endocarditis (EFIE) are needed. Some in vitro studies have suggested daptomycin and ceftaroline have synergistic activity against E. faecalis. We aimed to assess the in vitro and in vivo activity of daptomycin in combination with ceftaroline against E. faecalis clinical isolates with and without high-level of aminoglycoside resistance (HLAR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A panel of six endocarditis-associated E. faecalis isolates were used for time\u2013kill assays at initial standard and high inocula. Daptomycin (10\u2005mg\/kg\/day intravenously) and daptomycin (10\u2005mg\/kg\/day iv) plus ceftaroline (600\u2005mg q12\u2005hours intravenous) were compared in vivo using a human-like pharmacokinetic model in two treatment groups using the experimental EFIE model in rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The combination of daptomycin plus ceftaroline achieved synergy against all three HLAR and all three non-HLAR strains in time\u2013kill assays at initial standard inoculum. A bactericidal effect was observed in two of the three HLAR E. faecalis isolates. For HLAR EFAE-188, the use of daptomycin plus ceftaroline significantly decreased the bacterial density in vegetations compared with daptomycin alone (median density 5.2 versus 6.7 log10 cfu\/g; P\u200a=\u200a0.028). For non-HLAR EFAE-468, the bacterial density in vegetations was lower with the combination therapy than with daptomycin alone (median density 5.2 versus 6.8 log10 cfu\/g; P\u200a=\u200a0.072). Adding ceftaroline prevented the development of daptomycin-resistant E. faecalis isolates in all cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daptomycin plus ceftaroline represents a promising alternative for treating EFIE. Further clinical studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag136","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:28:26Z","timestamp":1775561306000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to\n                    <i>Enterococcus faecalis<\/i>\n                    with and without high-level aminoglycoside resistance"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-7204","authenticated-orcid":false,"given":"Mar\u00eda-Alexandra","family":"Ca\u00f1as","sequence":"first","affiliation":[{"name":"Hospital Clinic\u2014Institut D\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), University of Barcelona , Barcelona 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