{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:07:42Z","timestamp":1780506462218,"version":"3.54.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["GNT2009677"],"award-info":[{"award-number":["GNT2009677"]}]},{"name":"National Health and Medical Research Council of Australia","award":["GNT1196520"],"award-info":[{"award-number":["GNT1196520"]}]},{"name":"National Health and Medical Research Council of Australia","award":["GNT2014388"],"award-info":[{"award-number":["GNT2014388"]}]},{"name":"National Health and Medical Research Council of Australia","award":["APP1176180"],"award-info":[{"award-number":["APP1176180"]}]},{"name":"The University of Queensland Research Training"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Enterococcus faecium and Staphylococcus aureus are opportunistic bacterial pathogens with a demonstrated capacity to develop antimicrobial resistance and cause serious life-threatening infections, underscoring the urgent need for new therapeutic options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we have synthesized and characterized the activities of an 8-hydroxyquinoline\u2013based ionophore antibiotic (ionophoroantibiotic; IP antibiotic), designated \u2018IP-antibiotic 12.\u2019<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using multidrug-resistant strains of E. faecium and S. aureus, in vitro investigations revealed that IP-antibiotic 12 exhibits bactericidal activity, demonstrates a low propensity for resistance emergence, increases the susceptibility of particular strains to select antibiotics, possesses a favorable toxicity profile, and dysregulates bacterial metal homeostasis. IP-antibiotic 12 demonstrated therapeutic efficacy against multidrug-resistant S. aureus skin infection, as a direct-acting topical antimicrobial and antibiotic adjunct when co-administered with oral linezolid. Interestingly, it was not efficacious in murine models of systemic and pulmonary infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results highlight the potential of IP-antibiotic 12 as a novel therapeutic against multidrug-resistant gram-positive bacteria and provide a foundation for the development of next-generation IP-antibiotics with enhanced in vivo therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag186","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:57:16Z","timestamp":1778673436000},"source":"Crossref","is-referenced-by-count":0,"title":["Newly identified antimicrobial activity of an 8-hydroxyquinoline-based ionophore against multidrug-resistant\n                    <i>Enterococcus faecium<\/i>\n                    and\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"81","author":[{"given":"Gen","family":"Li","sequence":"first","affiliation":[{"name":"Australian Infectious Diseases Research Centre, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":"Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M","family":"El-Deeb","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine and Glycomics, Griffith University , Southport, QLD 4222 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden G","family":"Whyte","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":"Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A T","family":"Blaskovich","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":"Community for Open Antimicrobial Drug Discovery, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Walker","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre, Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":"Centre for Superbug Solutions, Institute for Molecular 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