{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:00:23Z","timestamp":1780905623109,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pulmonary aspergillosis (CPA) requires prolonged oral azole therapy, yet 30%\u201340% experience relapse after treatment discontinuation. The role of nebulized amphotericin B (NAB) in CPA as a maintenance therapy remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed CPA patients treated with NAB deoxycholate (10\u2005mg twice daily) preparation administered either on alternate days (three times weekly) or six times weekly (6\/7-day). The primary objective was to compare the efficacy and safety of these two dosage schedules in maintaining CPA remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 36 subjects (28 chronic cavitary pulmonary aspergillosis, 8 chronic fibrosing pulmonary aspergillosis ). Most received oral itraconazole (n\u200a=\u200a34) for a median duration of 12\u2005months before NAB initiation. Patients received NAB on alternate days (n\u200a=\u200a16) or 6\/7-day (n\u200a=\u200a20) for a median duration of 11\u2005months. Of 34 evaluable patients with a median follow-up of 27\u2005months, remission was maintained in 23 (67.6%) during NAB therapy, with significantly higher rates with 6\/7-day versus alternate-day therapy (16\/19 [84.2%] versus 7\/15 [46.7%]; P\u200a=\u200a0.020). CPA relapse occurred in 11 patients (32.4%), more frequently with alternate-day treatment (8\/15 [53.3%] versus 3\/19 [15.8]; P\u200a=\u200a0.020). Adverse events occurred in eight patients (22.2%), including bronchospasm (n\u200a=\u200a5) and haemoptysis (n\u200a=\u200a1); two discontinued NAB due to intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nebulized amphotericin B deoxycholate maintained CPA remission in two-thirds of patients, with 6\/7-day administration achieving significantly better outcomes than alternate-day therapy. Prospective randomized controlled trials are needed to establish NAB as standard maintenance therapy in CPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag200","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:46:47Z","timestamp":1779968807000},"source":"Crossref","is-referenced-by-count":0,"title":["Nebulized amphotericin B deoxycholate in management of chronic pulmonary aspergillosis: experience from a tertiary care centre in North India"],"prefix":"10.1093","volume":"81","author":[{"given":"Inderpaul Singh","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 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