{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:02:30Z","timestamp":1781010150343,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Artificial Heart Frontier Program Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Driveline infection, exemplifying medical device\u2013associated infection, is a difficult-to-treat complication of ventricular assist device implantation in which biofilm formation underlies both infection onset and recurrence. Although clinical experience remains limited, treatment success has been reported in cases where local antibiotics at high concentrations were used in combination with surgical debridement and\/or device reimplantation. We recently identified the low metabolic state of biofilm cells as the central mechanism underlying the high antimicrobial resistance of staphylococcal biofilms and as a potential therapeutic target for driveline infections. We hypothesize that rationally combining weakly and strongly metabolism-dependent antibiotics at high concentrations for an extended period may eradicate staphylococcal biofilms, including the embedded tolerant and persister cells. If clinically validated, this strategy may hold the key to achieving long-term treatment success in many medical device\u2013associated infections, including the driveline infection.<\/jats:p>","DOI":"10.1093\/jac\/dkag203","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:50:55Z","timestamp":1780055455000},"source":"Crossref","is-referenced-by-count":0,"title":["Using biofilm-targeting local antibiotics to treat recalcitrant medical device\u2013associated infections: driveline infection as a model"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-708X","authenticated-orcid":false,"given":"Yue","family":"Qu","sequence":"first","affiliation":[{"name":"Infection Theme, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University , Clayton, Victoria 3800 ,","place":["Australia"]},{"name":"Department of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University , Melbourne, Victoria 3004 ,","place":["Australia"]},{"name":"The Consortium for Infection and Innovation (CII), The First Affiliated Hospital of Wenzhou Medical University , Zhejiang 325000 ,","place":["China"]},{"name":"Centre to Impact AMR, Monash University , Melbourne, Victoria 3800 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Alfred Hospital and Central Clinical School, Monash University , Melbourne, Victoria 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McGiffin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Alfred Hospital and Monash University , Melbourne, Victoria 3004 ,","place":["Australia"]},{"name":"Critical Care Research Group , Brisbane, Queensland 4000 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