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This is based on decades of clinical practice. The high acute kidney injury rates seen with (flu)cloxacillin in the recently published SNAP trial, which is the largest randomized clinical trial ever in S. aureus bacteraemia (SAB), shows us the need to regularly test and question our usual clinical practice. Acute kidney injury is common in SAB when high doses of (flu)cloxacillin are used. The contribution of (flu)cloxacillin to developing or exacerbating acute kidney injury is likely to have been under recognized until now. Caution needs to be taken with (flu)cloxacillin. Cefazolin provides a safer and equally efficacious treatment for SAB. We discuss how this new evidence might be combined with our existing knowledge and the results of the CloCeBa trial to guide us how to appropriately manage our patients.<\/jats:p>","DOI":"10.1093\/jac\/dkag215","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:42:58Z","timestamp":1780746178000},"source":"Crossref","is-referenced-by-count":3,"title":["A review of the randomized clinical trial results from the\n                    <i>Staphylococcus aureus<\/i>\n                    network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-9017","authenticated-orcid":false,"given":"Anna L","family":"Goodman","sequence":"first","affiliation":[{"name":"University College London Innovative Clinical Trials Unit Institute of Clinical Trials and Methodology, , London ,","place":["UK"]},{"name":"Department of Infection, Guy's and St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]},{"name":"Department of Infection, King's College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6413-919X","authenticated-orcid":false,"given":"Nicholas","family":"Easom","sequence":"additional","affiliation":[{"name":"Infection Research Group, Hull University Teaching Hospitals NHS Trust , Hull ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-0032","authenticated-orcid":false,"given":"Dana","family":"Bielopolski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Guy's and St Thomas\u2019 Hospitals NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-9630","authenticated-orcid":false,"given":"Rebecca K","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-4743","authenticated-orcid":false,"given":"Michael","family":"Marks","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine , London ,","place":["UK"]},{"name":"Hospital for Tropical Diseases, University College London Hospitals , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein P M","family":"Hensgens","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"University Medical Center Utrecht, Utrecht University Julius Center for Health Sciences and Primary Care, , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bonten","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht, Utrecht University Julius Center for Health Sciences and Primary Care, , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-9350","authenticated-orcid":false,"given":"Jennifer","family":"Bostock","sequence":"additional","affiliation":[{"name":"Public Engagement Representative- no Affiliations ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9052-0682","authenticated-orcid":false,"given":"Genevieve","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Middlemore Hospital , Auckland ,","place":["New 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,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2317-1112","authenticated-orcid":false,"given":"Mical","family":"Paul","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus, Unit of Infectious Diseases, Haifa ,","place":["Israel"]},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology , Haifa ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-125X","authenticated-orcid":false,"given":"Fran\u00e7ois-Xavier","family":"Lescure","sequence":"additional","affiliation":[{"name":"Hopital Bichat - Claude-Bernard, Service des Maladies Infectieuses et Tropicales , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-4239","authenticated-orcid":false,"given":"Todd 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,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-5699","authenticated-orcid":false,"given":"Joshua S","family":"Davis","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University , Darwin, Northern Territory ,","place":["Australia"]},{"name":"Department of Infectious Diseases, John Hunter Hospital , Newcastle, NSW 2301 ,","place":["Australia"]},{"name":"University of Newcastle School of Medicine and Public Health, , Newcastle ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026070305580571700_dkag215-B1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1001\/jama.2025.4288","article-title":"Management of Staphylococcus aureus bacteremia: a 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Observations from a systematic review of attributable mortality","volume":"9","author":"Bai","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2026070305580571700_dkag215-B6","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac653","article-title":"All-cause and infection-related mortality in Staphylococcus aureus bacteremia, a multicenter prospective cohort study","volume":"9","author":"van der Vaart","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2026070305580571700_dkag215-B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2026070305580571700_dkag215-B8","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 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