{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:27:30Z","timestamp":1789644450862,"version":"4.0.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthetic joint infections (PJI) of the hip and knee are most often caused by Staphylococcus spp. and require long-term treatment with rifampicin and fluoroquinolone as first-line treatment. However, resistance, contraindications or intolerance highlight the need for effective oral alternatives. Tetracyclines, with favourable bioavailability and bone penetration, represent a potential option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CYCLIOS, a multicentre retrospective matched case\u2013control study, included adult patients with staphylococcal hip or knee PJI treated with curative intent. Cases received doxycycline as part of their antibiotic regimen, and controls were matched 1:2 on infection site, age, pathogen and date of multidisciplinary meeting. The primary endpoint was a composite of death or treatment failure at 2\u2005years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-seven patients were analysed (23 doxycycline group, 44 control). The two groups were comparable except for immunosuppression (17% (4\/23) versus 2% (1\/44); P\u200a=\u200a0.04). The median duration of doxycycline was 75\u2005days (interquartile range [IQR]: 47\u201383). The primary endpoint occurred in 43% (10\/23 and 19\/44) of both groups (odds ratio [OR] 1.01, 95% confidence interval [CI] [0.36\u20132.84]; P\u200a=\u200a0.98). Treatment-related adverse events were reported in 35% (8\/23) versus 20% (9\/44); P\u200a=\u200a0.24, but premature discontinuation remained rare (4% (1\/23) versus 5% (2\/44); P\u200a=\u200a1.00). In the conditional logistic regression model, doxycycline exposure was not associated with an increased risk of unfavourable outcome (univariate OR 1.06, 95% CI [0.40\u20132.81]; P\u200a=\u200a0.91 and multivariate OR 0.97, 95% CI [0.23\u20134.25]; P\u200a=\u200a0.97).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this multicentre real-life study, doxycycline-based regimen, no significant difference was observed between doxycycline-based regimens and comparator strategies, with acceptable tolerability. Given the observational design and limited sample size, these findings should be considered exploratory. Tetracyclines may represent a pragmatic therapeutic alternative when first-line options are not feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag219","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:31:27Z","timestamp":1781613087000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of doxycycline in treatment of\n                    <i>Staphylococcus<\/i>\n                    spp. prosthetic joint infections: a CRIOGO multicentre case\u2013control study"],"prefix":"10.1093","volume":"81","author":[{"given":"Vincent","family":"Fiorenza","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, CHU de Poitiers Site de la Mil\u00e9trie , Poitiers 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