{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:08:02Z","timestamp":1784128082945,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 114-2311-B-037-002"],"award-info":[{"award-number":["NSTC 114-2311-B-037-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-TB114001-2"],"award-info":[{"award-number":["KMU-TB114001-2"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Scedosporium and Lomentospora species are intrinsically resistant moulds increasingly implicated in invasive infections. Olorofim, a novel orotomide antifungal, has demonstrated potent activity against several moulds. This study evaluated the antifungal susceptibility of clinical and environmental isolates, focusing on olorofim, and examined these data in a phylogenetic context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 216 isolates (Scedosporium spp., n\u200a=\u200a205; L. prolificans, n\u200a=\u200a11) were collected from clinical and environmental sources across Taiwan. Antifungal susceptibility was determined using the CLSI M38-A3 method. Correlation analyses assessed cross-resistance patterns, while phylogenetic signal, Mantel tests, and variance partitioning were used to evaluate evolutionary structuring of MICs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Scedosporium apiospermum (46.3%) and S. boydii (15.7%) were the predominant species, exhibiting comparable triazole susceptibility profiles (MIC90: voriconazole 1\u20132\u2005mg\/L, posaconazole 4\u2005mg\/L, and isavuconazole 8\u2005mg\/L). L. prolificans displayed pan-resistance to all agents except olorofim. Olorofim exhibited the lowest MICs across Scedosporium spp. and L. prolificans (all MIC90\u200a\u2264\u200a0.12\u2005mg\/L). The isolate source exerted limited biological impact on antifungal susceptibility campared with species-specific characteristics. The association between antifungal susceptibility and species relatedness varied by drug: moderate for posaconazole, amphotericin B, and voriconazole; intermediate for olorofim; weak for isavuconazole; and absent for itraconazole. The majority of MIC variability (72.5%\u201389.2%) was observed within rather than between species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Susceptibility in Scedosporium and Lomentospora exhibits high intraspecies variability. Triazoles showed only moderate phylogenetic conservation and cross-resistance, whereas olorofim demonstrated potent, independent activity across all taxa. Given the limited predictive value of species identity, individual susceptibility testing remains essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag236","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:20:22Z","timestamp":1784006422000},"source":"Crossref","is-referenced-by-count":0,"title":["Antifungal susceptibility profiles of clinical and environmental\n                    <i>Scedosporium<\/i>\n                    and\n                    <i>Lomentospora<\/i>\n                    isolates from Taiwan: focus on olorofim activity and phylogenetic heterogeneity"],"prefix":"10.1093","volume":"81","author":[{"given":"Shang-Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital , Kaohsiung ,","place":["Taiwan"]},{"name":"College of Medicine, Kaohsiung Medical University , Kaohsiung ,","place":["Taiwan"]},{"name":"Department of Laboratory Medicine, Kaohsiung Medical University Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Abdrabo El-Sayid","family":"Abdrabo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University , Kaohsiung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Mao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University , Kaohsiung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital , Linkou Branch, Taoyuan ,","place":["Taiwan"]},{"name":"College of Medicine, Chang Gung University , Taoyuan ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-355X","authenticated-orcid":false,"given":"Chong Kei","family":"Lao","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital , Taoyuan ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chang Gung Memorial Hospital , Linkou Branch, Taoyuan ,","place":["Taiwan"]},{"name":"College of Medicine, Chang Gung University , Taoyuan ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Jung","family":"Wu","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Tainan ,","place":["Taiwan"]},{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-0688","authenticated-orcid":false,"given":"Passanesh","family":"Sukphopetch","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University , Bangkok \u00a0","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-6603","authenticated-orcid":false,"given":"Sharon C 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