{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:20:03Z","timestamp":1784035203875,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011004","name":"French Ministry of Agriculture and Food Sovereignty","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011004","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union, the State, and the R\u00e9union Region"},{"DOI":"10.13039\/501100014141","name":"European Agricultural Fund for Rural Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carbapenemase-producing Enterobacterales (CPE) are a significant public health concern, associated with high morbidity and mortality rates due to restricted antibiotic treatment options. Among the genetic determinants of CPE resistance, imipenemase (IMI) mediated resistance is an emerging problem in infections involving bacteria of the Enterobacter cloacae complex (ECC) and has been linked to worldwide clinical cases, including community-level outbreaks in the Indian Ocean region. Little is known about the potential role of animals as reservoirs of multidrug-resistant ECC bacteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Characterize blaIMI-4 carbapenemase-producing ECC strains isolated from patients and a companion animal in the southwestern Indian Ocean region (R\u00e9union and Mayotte islands).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used antibiotic susceptibility testing to determine available treatment and genome sequencing to characterize resistance gene variants and mobile genetic elements carrying blaIMI-4 genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>blaIMI-4 ECC isolates are susceptible to new antibiotics active on Class A carbapenemase, notably \u03b2-lactams-inhibitors (ceftazidime\u2013avibactam, meropenem\u2013vaborbactam). The blaIMI-4 gene was identified on a common EcloIMEX-2 mobile integrative element in (i) ST 2370 Enterobacter sichuanensis isolated from a dog in R\u00e9union and (ii) ST1845 Enterobacter roggenkampii clinical isolates from R\u00e9union and Mayotte islands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Companion animals may play a role in the persistence and spread of mobile genetic elements that confer carbapenem resistance in diverse Enterobacter species.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag243","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:00:34Z","timestamp":1784034034000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of IMI-4 carbapenemase-producing\n                    <i>Enterobacter<\/i>\n                    sp. isolated from humans and a companion animal in French Indian Ocean territories"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-6212","authenticated-orcid":false,"given":"David A","family":"Wilkinson","sequence":"first","affiliation":[{"name":"UMR ASTRE, Cirad - BIOS, plateforme CYROI , 2 Rue Maxime Rivi\u00e8re, Sainte Clotilde, La R\u00e9union 97490 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Sellier","sequence":"additional","affiliation":[{"name":"UMR ASTRE, Cirad - BIOS, plateforme CYROI , 2 Rue Maxime Rivi\u00e8re, Sainte Clotilde, La R\u00e9union 97490 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9a","family":"Maurines-Carboneill","sequence":"additional","affiliation":[{"name":"UMR ASTRE, Cirad - BIOS, plateforme CYROI , 2 Rue Maxime Rivi\u00e8re, Sainte Clotilde, La R\u00e9union 97490 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