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Its large genome supports extensive metabolic diversity and promotes its adaptation to diverse environments. The survival and persistence of P. aeruginosa in clinical settings is further facilitated by a vast arsenal of strategies that contribute to its tolerance or resistance to antibiotics. Here, we aimed to systematically identify the genetic determinants that affect its susceptibility to antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ordered PA14 transposon mutant library was grown in the presence of sub-MIC concentrations of a panel of antibiotics of various classes, and the growth of each mutant was quantified to generate susceptibility scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a dense network of genes affecting antibiotic susceptibility in P. aeruginosa, where a large portion of genes modulated susceptibility to various classes of antibiotics. Not surprisingly, efflux and outer membrane permeability were key contributors, but we also identified genes that are not typically associated with antibiotic susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data provide a genome-wide view of the antibiotic susceptibility network in P. aeruginosa. Overall, our approach deepens our understanding of antibiotic susceptibility and opens new avenues for developing strategies against multidrug-resistant P. aeruginosa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag272","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:36:56Z","timestamp":1784979416000},"source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide network of antibiotic susceptibility in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1093","volume":"81","author":[{"given":"Oc\u00e9ane","family":"Goncalves","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biologie, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec J1K 2R1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-6834","authenticated-orcid":false,"given":"Jean-Philippe","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec J1K 2R1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026080505372718400_dkag272-B1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fcimb.2017.00039","article-title":"Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival, and persistence","volume":"7","author":"Moradali","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"2026080505372718400_dkag272-B2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1574-6976.2011.00269.x","article-title":"Pseudomonas genomes: diverse and adaptable","volume":"35","author":"Silby","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"2026080505372718400_dkag272-B3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41392-022-01056-1","article-title":"Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics","volume":"7","author":"Qin","year":"2022","journal-title":"Sig Transduct Target Ther"},{"key":"2026080505372718400_dkag272-B4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.biotechadv.2018.11.013","article-title":"Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies","volume":"37","author":"Pang","year":"2019","journal-title":"Biotechnol Adv"},{"key":"2026080505372718400_dkag272-B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126468","article-title":"What it takes to be a Pseudomonas aeruginosa? 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