{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:16:07Z","timestamp":1788142567061,"version":"build-2803163510"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Health Protection Unit"},{"DOI":"10.13039\/100018336","name":"NIHR HPRU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICHT Charity Fellowship to E.M"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An upsurge in Streptococcus pyogenes infections 2022\u20132023 highlighted potential benefits of point-of-care tests (POCT) to support clinical pathways, prevent outbreaks and optimize antibiotic use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We conducted a pilot research study in a west London paediatric emergency department (ED) to determine whether a molecular POCT had potential to alter management in children who were also having a conventional throat swab taken for culture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children &amp;lt;16\u2005years presenting to ED who had a throat swab requested by a clinician were invited to have a second swab taken for research purposes only. Clinical management was unaffected by the research swab result, which was processed using a molecular POCT that was not approved for use in the host NHS Trust.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of streptococcal infection was low during the study (May 2023\u2013June 2025); swab positivity in symptomatic children was 12.8% (6\/47). Overall, 38\/49 (77.6%) participants who had throat swabs received antibiotics. Of those children recommended to receive antibiotics, 29\/38 (76.3%) had a negative POCT. Mean time to reporting of positive throat swab culture results was 3.67\u2005days (range 3\u20135\u2005days) leading to occasional delay in treatment, although POCT identified positive results within minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibiotic use was frequent and could be avoided by use of a \u2018rule out\u2019 POCT in many children in the ED, provided suspicion of S. pyogenes is the main driver for prescribing. POCT were easy to process and produced immediate results compared with culture. More research is needed to establish whether POCT confers overall net benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag290","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:54:45Z","timestamp":1786190085000},"source":"Crossref","is-referenced-by-count":0,"title":["Group A Streptococcus molecular point of care testing in a paediatric emergency department"],"prefix":"10.1093","volume":"81","author":[{"given":"Ewurabena A","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Bingham","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud G","family":"Nijman","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London ,","place":["UK"]},{"name":"Department of Paediatric Emergency Medicine, Division of Medicine, St. Mary\u2019s Hospital, Imperial College NHS Healthcare Trust, London ,","place":["UK"]},{"name":"Centre for Paediatrics and Child Health, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5214-4941","authenticated-orcid":false,"given":"Shiranee","family":"Sriskandan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London ,","place":["UK"]},{"name":"NIHR Health Protection Research Unit in Healthcare Associated Infections and AMR, Department of Infectious Disease, Imperial College London , London ,","place":["UK"]},{"name":"Centre for Bacterial Resistance Biology, Imperial College London , London 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