{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:17:45Z","timestamp":1788513465578,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The global emergence and dissemination of epidemic Clostridioides difficile ribotype 027 (RT027) and related lineages illustrate the role of antimicrobial pressure in shaping the epidemiology of this pathogen. We propose a hierarchical model in which fluoroquinolones (FQs) served as the dominant selective force underlying the worldwide expansion of RT027-related strains, with rifampin and rifamycins acting as secondary modifiers that promoted persistence and regional dominance.<\/jats:p>","DOI":"10.1093\/jac\/dkag310","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:06:18Z","timestamp":1788512778000},"source":"Crossref","is-referenced-by-count":0,"title":["The underappreciated role of rifampin in shaping the epidemiology of RT027-like\n                    <i>Clostridioides difficile<\/i>\n                    lineages"],"prefix":"10.1093","volume":"81","author":[{"given":"Isabella A","family":"Tickler","sequence":"first","affiliation":[{"name":"Cepheid Department of Medical and Scientific Affairs, , 904 Caribbean Drive, Sunnyvale, CA 94089 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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