{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:01:45Z","timestamp":1790078505827,"version":"4.0.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Beihua University Graduate Innovation and Entrepreneurship Training Program","award":["[2025] 018"],"award-info":[{"award-number":["[2025] 018"]}],"id":[{"id":"https:\/\/ror.org\/013jjp941","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology projects"},{"DOI":"10.13039\/501100010211","name":"Jilin Province Department of Education","doi-asserted-by":"publisher","award":["JJKH20240092KJ"],"award-info":[{"award-number":["JJKH20240092KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013060","name":"Jilin Province Health and Family Planning Commission","doi-asserted-by":"publisher","award":["2022JC021"],"award-info":[{"award-number":["2022JC021"]}],"id":[{"id":"10.13039\/501100013060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that causes severe infections in pigs and humans. Bacterial autolysins play essential roles in cell-wall remodelling and virulence; however, the structural and functional characteristics of the SS2 autolysin ATL remain poorly understood. With the increasing emergence of antimicrobial resistance, anti-virulence strategies that attenuate bacterial pathogenicity without directly inhibiting growth have attracted increasing attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ATL domain organization was analysed bioinformatically. The catalytic domain was expressed, purified and crystallized, and its structure was determined at 1.8 \u00c5 resolution. An atl deletion mutant was generated, and ATL function was evaluated by autolysis, biofilm formation, adhesion and mouse infection assays. Lanreotide acetate was assessed for its effects on bacterial growth, ATL inhibition and anti-virulence activity in vitro and in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ATL contains cell-wall-binding repeats and a C-terminal Zn2+-dependent amidase domain with a His13\u2013Glu27\u2013His81 catalytic site. Deletion of atl did not affect bacterial growth but reduced autolysis, biofilm formation, adhesion and virulence in mice. Lanreotide acetate had a minimum inhibitory concentration (MIC) of 512\u2005mg\/L and showed no growth inhibition at sub-MIC concentrations. However, it inhibited ATL activity and reduced autolysis, biofilm formation, adhesion, barrier penetration and bacterial burden, while alleviating splenic pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ATL is a key SS2 virulence-associated autolysin. Lanreotide acetate attenuates SS2 pathogenicity by inhibiting ATL activity without suppressing bacterial growth, supporting ATL as a potential anti-virulence target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag326","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:53:35Z","timestamp":1788954815000},"source":"Crossref","is-referenced-by-count":0,"title":["Targeting autolysin ATL of\n                    <i>Streptococcus suis<\/i>\n                    : structural insights and inhibition by lanreotide acetate"],"prefix":"10.1093","volume":"81","author":[{"given":"Huiming","family":"Han","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlong","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Beihua University , Jilin ,","place":["China"]},{"name":"Center for Infection and Immunity, Beihua University , Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Science and Education, Affiliated Hospital of Beihua University , Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"2026092207091268000_dkag326-B1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.tvjl.2013.01.030","article-title":"Identification of a novel collagen type I-binding protein from Streptococcus suis serotype 2","volume":"197","author":"Zhang","year":"2013","journal-title":"Vet J"},{"key":"2026092207091268000_dkag326-B2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12915-024-01835-y","article-title":"Enolase of Streptococcus suis serotype 2 promotes biomolecular condensation of ribosomal protein SA for HBMECs apoptosis","volume":"22","author":"Jiang","year":"2024","journal-title":"BMC Biol"},{"key":"2026092207091268000_dkag326-B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.125202","article-title":"A CRISPR-Cas12a-based platform facilitates the detection and serotyping of Streptococcus suis serotype 2","volume":"267","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"2026092207091268000_dkag326-B4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1362316","article-title":"Pan-genome analysis of Streptococcus suis serotype 2 highlights genes associated with virulence and antibiotic resistance","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Microbiol"},{"key":"2026092207091268000_dkag326-B5","doi-asserted-by":"publisher","DOI":"10.34133\/2020\/2016201","article-title":"The strategies of pathogen-oriented therapy on circumventing antimicrobial resistance","volume":"2020","author":"Shang","year":"2020","journal-title":"Research (Wash D C)"},{"key":"2026092207091268000_dkag326-B6","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00118-23","article-title":"Staphylococcus capitis: insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species","volume":"37","author":"Crepin","year":"2024","journal-title":"Clin Microbiol Rev"},{"key":"2026092207091268000_dkag326-B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2301414120","article-title":"Autolysin-mediated peptidoglycan hydrolysis is required for the surface display of Staphylococcus aureus cell wall-anchored proteins","volume":"120","author":"Leonard","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026092207091268000_dkag326-B8","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1111\/mmi.13435","article-title":"The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity","volume":"101","author":"Sandalova","year":"2016","journal-title":"Mol Microbiol"},{"key":"2026092207091268000_dkag326-B9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.vetmic.2019.05.020","article-title":"A novel autolysin AtlASS mediates bacterial cell separation during cell division and contributes to full virulence in Streptococcus suis","volume":"234","author":"Zhang","year":"2019","journal-title":"Vet Microbiol"},{"key":"2026092207091268000_dkag326-B10","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s42003-020-01405-2","article-title":"New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus","volume":"3","author":"Nega","year":"2020","journal-title":"Commun Biol"},{"key":"2026092207091268000_dkag326-B11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1128\/JB.00926-12","article-title":"Cell death of Streptococcus mutans induced by a quorum-sensing peptide occurs via a conserved streptococcal autolysin","volume":"195","author":"Dufour","year":"2013","journal-title":"J Bacteriol"},{"key":"2026092207091268000_dkag326-B12","doi-asserted-by":"publisher","first-page":"36794","DOI":"10.1074\/jbc.M110.167312","article-title":"Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins","volume":"285","author":"Pasztor","year":"2010","journal-title":"J Biol Chem"},{"key":"2026092207091268000_dkag326-B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2022.102261","article-title":"Gaps in the wall: understanding cell wall biology to tackle amoxicillin resistance in Streptococcus pneumoniae","volume":"72","author":"Gibson","year":"2023","journal-title":"Curr Opin Microbiol"},{"key":"2026092207091268000_dkag326-B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104286","article-title":"Quebrachitol inhibits biofilm formation and virulence production against methicillin-resistant Staphylococcus aureus","volume":"149","author":"Vijayakumar","year":"2020","journal-title":"Microb Pathog"},{"key":"2026092207091268000_dkag326-B15","doi-asserted-by":"publisher","first-page":"7937","DOI":"10.1038\/s41467-024-52325-2","article-title":"Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode","volume":"15","author":"Alvarez","year":"2024","journal-title":"Nat Commun"},{"key":"2026092207091268000_dkag326-B16","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1099\/mic.0.2007\/015172-0","article-title":"A novel cell wall-anchored peptidoglycan hydrolase (autolysin), IspC, essential for Listeria monocytogenes virulence: genetic and proteomic analysis","volume":"154","author":"Wang","year":"2008","journal-title":"Microbiology (Reading)"},{"key":"2026092207091268000_dkag326-B17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molimm.2021.09.011","article-title":"Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages","volume":"140","author":"Cao","year":"2021","journal-title":"Mol Immunol"},{"key":"2026092207091268000_dkag326-B18","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1038\/s41598-018-24152-1","article-title":"DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages","volume":"8","author":"Herta","year":"2018","journal-title":"Sci Rep"},{"key":"2026092207091268000_dkag326-B19","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1128\/IAI.02811-14","article-title":"Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response","volume":"83","author":"Ramos-Sevillano","year":"2015","journal-title":"Infect Immun"},{"key":"2026092207091268000_dkag326-B20","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1128\/IAI.00364-10","article-title":"Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype","volume":"79","author":"Houston","year":"2011","journal-title":"Infect Immun"},{"key":"2026092207091268000_dkag326-B21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23845","article-title":"Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus","volume":"6","author":"Mashruwala","year":"2017","journal-title":"Elife"},{"key":"2026092207091268000_dkag326-B22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.728989","article-title":"Adaptation of Staphylococcus aureus to the human skin environment identified using an ex vivo tissue model","volume":"12","author":"Burian","year":"2021","journal-title":"Front Microbiol"},{"key":"2026092207091268000_dkag326-B23","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1128\/JB.06231-11","article-title":"Characterization and functional analysis of atl, a novel gene encoding autolysin in Streptococcus suis","volume":"194","author":"Ju","year":"2012","journal-title":"J Bacteriol"},{"key":"2026092207091268000_dkag326-B24","first-page":"68","article-title":"Identification and characterization of a novel infection-related factor (cell wall hydrolase\/autolysin) of Streptococcus suis serotype 2","volume":"48","author":"Gu","year":"2008","journal-title":"Wei Sheng Wu Xue Bao"},{"key":"2026092207091268000_dkag326-B25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13568-024-01736-x","article-title":"Coptis rhizome extract influence on Streptococcus pneumoniae through autolysin activation","volume":"14","author":"Lee","year":"2024","journal-title":"AMB Express"},{"key":"2026092207091268000_dkag326-B26","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.2147\/IDR.S455339","article-title":"Inhibiting peptidoglycan hydrolase alleviates MRSA pneumonia through autolysin-mediated MDP-NOD2 pathway","volume":"17","author":"Yang","year":"2024","journal-title":"Infect Drug Resist"},{"key":"2026092207091268000_dkag326-B27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.892364","article-title":"Molecular characterization of predominant serotypes, drug resistance, and virulence genes of Streptococcus pneumoniae isolates from East China","volume":"13","author":"Huang","year":"2022","journal-title":"Front Microbiol"},{"key":"2026092207091268000_dkag326-B28","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00252-17","article-title":"Atla mediates extracellular DNA release, which contributes to Streptococcus mutans biofilm formation in an experimental rat model of infective endocarditis","volume":"85","author":"Jung","year":"2017","journal-title":"Infect Immun"},{"key":"2026092207091268000_dkag326-B29","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071378","article-title":"Peptide-based bioconjugates and therapeutics for targeted anticancer therapy","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026092207091268000_dkag326-B30","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082108","article-title":"iRGD-targeted peptide nanoparticles for anti-angiogenic RNAi-based therapy of endometriosis","volume":"15","author":"Egorova","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026092207091268000_dkag326-B31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1517\/14656566.2016.1127914","article-title":"Lanreotide for the treatment of gastroenteropancreatic neuroendocrine tumors","volume":"17","author":"Saif","year":"2016","journal-title":"Expert Opin Pharmacother"},{"issue":"Suppl 1","key":"2026092207091268000_dkag326-B32","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1007\/s11102-010-0287-7","article-title":"Tamoxifen enhances the control of acromegaly treated with somatostatin analog lanreotide","volume":"15","author":"Maiza","year":"2012","journal-title":"Pituitary"},{"key":"2026092207091268000_dkag326-B33","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1080\/09513590.2017.1404240","article-title":"Pregnancy in women after successful acromegaly treatment, including surgical removal of pituitary adenoma and postoperative therapy using lanreotide acetate","volume":"33","author":"Teltayev","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"2026092207091268000_dkag326-B34","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00082","article-title":"Identification of novel laminin- and fibronectin-binding proteins by far-western blot: capturing the adhesins of Streptococcus suis type 2","volume":"5","author":"Li","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"2026092207091268000_dkag326-B35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"2026092207091268000_dkag326-B36","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00382-20","article-title":"In silico structure-based repositioning of approved drugs for spike glycoprotein S2 domain fusion peptide of SARS-CoV-2: rationale from molecular dynamics and binding free energy calculations","volume":"5","author":"Shekhar","year":"2020","journal-title":"mSystems"},{"key":"2026092207091268000_dkag326-B37","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04750-22","article-title":"DivIVA interacts with the cell wall hydrolase MltG to regulate peptidoglycan synthesis in Streptococcus suis","volume":"11","author":"Jiang","year":"2023","journal-title":"Microbiol Spectr"},{"key":"2026092207091268000_dkag326-B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126829","article-title":"Biofilm patterns in gram-positive and gram-negative bacteria","volume":"251","author":"Ruhal","year":"2021","journal-title":"Microbiol Res"},{"key":"2026092207091268000_dkag326-B39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02724-16","article-title":"Downregulation of autolysin-encoding genes by phage-derived lytic proteins inhibits biofilm formation in Staphylococcus aureus","volume":"61","author":"Fern\u00e1ndez","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2026092207091268000_dkag326-B40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3201\/eid3003.230348","article-title":"Molecular epidemiology of underreported emerging zoonotic pathogen Streptococcus suis in Europe","volume":"30","author":"Brizuela","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"2026092207091268000_dkag326-B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2020.151463","article-title":"Characterization of the Atl-mediated staphylococcal internalization mechanism","volume":"310","author":"Schlesier","year":"2020","journal-title":"Int J Med Microbiol"},{"key":"2026092207091268000_dkag326-B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282843","article-title":"Naturally occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses","volume":"18","author":"Wong","year":"2023","journal-title":"PLoS One"},{"key":"2026092207091268000_dkag326-B43","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41589-021-00803-9","article-title":"Modification of cell wall polysaccharide guides cell division in Streptococcus mutans","volume":"17","author":"Zamakhaeva","year":"2021","journal-title":"Nat Chem Biol"},{"key":"2026092207091268000_dkag326-B44","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00056-22","article-title":"The major autolysin Atl regulates the virulence of Staphylococcus aureus by controlling the sorting of LukAB","volume":"90","author":"Zheng","year":"2022","journal-title":"Infect Immun"},{"key":"2026092207091268000_dkag326-B45","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12667","article-title":"Antimicrobial peptides properties beyond growth inhibition and bacterial killing","volume":"10","author":"Castillo-Ju\u00e1rez","year":"2022","journal-title":"PeerJ"},{"key":"2026092207091268000_dkag326-B46","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030439","article-title":"Glycosylation and lipidation strategies: approaches for improving antimicrobial peptide efficacy","volume":"16","author":"Bellavita","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026092207091268000_dkag326-B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.106609","article-title":"Attenuation of Las\/Rhl quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 by artocarpesin","volume":"189","author":"Mohan","year":"2024","journal-title":"Microb Pathog"},{"key":"2026092207091268000_dkag326-B48","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00635-20","article-title":"Abam regulates quorum sensing, biofilm formation, and virulence in Acinetobacter baumannii","volume":"203","author":"L\u00f3pez-Mart\u00edn","year":"2021","journal-title":"J Bacteriol"},{"key":"2026092207091268000_dkag326-B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108905","article-title":"Structure-activity relationship and molecular interaction mechanisms of the ACE-inhibitory tripeptide LL-X","volume":"164","author":"Yang","year":"2025","journal-title":"Bioorg Chem"},{"key":"2026092207091268000_dkag326-B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2023.105209","article-title":"The dual M protein systems have diverse biological characteristics, but both contribute to M18-type group A Streptococcus pathogenicity","volume":"27","author":"Zhou","year":"2025","journal-title":"Microbes Infect"},{"key":"2026092207091268000_dkag326-B51","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2451173","article-title":"Virulence and pathogenicity of group B Streptococcus: virulence factors and their roles in perinatal infection","volume":"16","author":"Megli","year":"2025","journal-title":"Virulence"},{"key":"2026092207091268000_dkag326-B52","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00273-24","article-title":"The group A Streptococcus pathogenicity island RD2: virulence role and barriers to conjugative transfer","volume":"93","author":"Roshika","year":"2025","journal-title":"Infect Immun"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/81\/10\/dkag326\/71310381\/dkag326.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/81\/10\/dkag326\/71310381\/dkag326.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:28Z","timestamp":1790075368000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/doi\/10.1093\/jac\/dkag326\/8827526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkag326","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,1]]},"article-number":"dkag326"}}