{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:39:27Z","timestamp":1792809567736,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutibacterium acnes, a human commensal, occasionally causes infections requiring long-term antibiotic treatment, including periprosthetic joint infections. Dalbavancin is a new lipoglycopeptide that allows intermittent dosing because of its exceptionally long half-life. However, data on susceptibility of C. acnes to dalbavancin are lacking, and no EUCAST breakpoints have been defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the MIC distribution of C. acnes for dalbavancin, and to compare the gradient test to the agar dilution reference method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C. acnes isolates were obtained from tissue samples from arthroplasties (n\u200a=\u200a117), skin samples (n\u200a=\u200a15), and positive blood cultures (n\u200a=\u200a85). Antibiotic susceptibility was tested by agar dilution according to EUCAST methodology for anaerobic bacteria (\u00b1polysorbate 80) and by gradient test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MIC50 and MIC90 for dalbavancin against C. acnes were 0.03 and 0.06\u2005mg\/L using agar dilution, and 0.004 and 0.008\u2005mg\/L with the gradient test. The gradient test yielded 3-fold lower MIC values than agar dilution. No significant difference was observed when polysorbate 80 was added to the agar dilution test. When vancomycin was tested as a comparator, the MICs did not differ between the agar dilution and gradient tests; MIC50 and MIC90 were 0.5\u2005mg\/L in both tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>C. acnes showed significantly lower MIC values for dalbavancin than for vancomycin, highlighting the potential of dalbavancin as a therapeutic option. The gradient test yielded significantly lower MICs for dalbavancin than the reference method for anaerobes, agar dilution, suggesting that the gradient test for dalbavancin may not be a reliable method for antibiotic susceptibility testing (AST) of C. acnes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkag364","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:03:34Z","timestamp":1792659814000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    susceptibility of\n                    <i>Cutibacterium acnes<\/i>\n                    to dalbavancin: comparison between gradient test and the agar dilution reference method"],"prefix":"10.1093","volume":"81","author":[{"given":"Sara","family":"Svensson","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro ,","place":["Sweden"]},{"name":"Department of Orthopedics, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Jacobsson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-3667","authenticated-orcid":false,"given":"Erika","family":"Matuschek","sequence":"additional","affiliation":[{"name":"EUCAST Development Laboratory, Clinical Microbiology, V\u00e4xj\u00f6 Hospital , V\u00e4xj\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-2932","authenticated-orcid":false,"given":"Bo","family":"S\u00f6derquist","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro ,","place":["Sweden"]},{"name":"Department of Orthopedics, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"2026102322225349200_dkag364-B1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1128\/CMR.00092-13","article-title":"Propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen","volume":"27","author":"Achermann","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2026102322225349200_dkag364-B2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jinf.2007.02.006","article-title":"Propionibacterium acnes: an agent of prosthetic joint infection and colonization","volume":"55","author":"Zeller","year":"2007","journal-title":"J Infect"},{"key":"2026102322225349200_dkag364-B3","author":"European Medicines Agency"},{"key":"2026102322225349200_dkag364-B4","author":"Durata Therapeutics"},{"key":"2026102322225349200_dkag364-B5","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/phar.1641","article-title":"Dalbavancin and oritavancin: an innovative approach to the treatment of gram-positive infections","volume":"35","author":"Roberts","year":"2015","journal-title":"Pharmacotherapy"},{"key":"2026102322225349200_dkag364-B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106960","article-title":"Expert opinion on dose regimen and therapeutic drug monitoring for long-term use of dalbavancin: expert review panel","volume":"62","author":"Senneville","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"2026102322225349200_dkag364-B7","unstructured":"The European Committee on Antimicrobial Susceptibility Testing\n          . 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