{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:16:26Z","timestamp":1763662586719},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"DOI":"10.1093\/jac\/dkl083","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T01:23:56Z","timestamp":1142299436000},"page":"983-986","source":"Crossref","is-referenced-by-count":17,"title":["Combinations of PBPs and MurM protein variants in early and contemporary high-level penicillin-resistant Streptococcus pneumoniae isolates in Spain"],"prefix":"10.1093","volume":"57","author":[{"given":"Rosa","family":"del Campo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cafini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Morosini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asunci\u00f3n","family":"Fenoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Li\u00f1ares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sevillano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Cant\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Baquero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,13]]},"reference":[{"key":"key\n\t\t\t\t20171010172621_B1","doi-asserted-by":"crossref","unstructured":"Fenoll A, Jado I, Vicioso D et al. Evolution of Streptococcus pneumoniae serotypes and antibiotic resistance in Spain: update (1990\u20131996). J Clin Microbiol1998; 36: 3447\u201354.","DOI":"10.1128\/JCM.36.12.3447-3454.1998"},{"key":"key\n\t\t\t\t20171010172621_B2","doi-asserted-by":"crossref","unstructured":"Smith AM, Botha RF, Koornhof HJ et al. Emergence of a pneumococal clone with cephalosporin resistance and penicillin susceptibility. Antimicrob Agents Chemother2001; 45: 2648\u201350.","DOI":"10.1128\/AAC.45.9.2648-2650.2001"},{"key":"key\n\t\t\t\t20171010172621_B3","doi-asserted-by":"crossref","unstructured":"Smith AM, Feldman C, Massidda O et al. Altered PBP2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother2005; 49: 2002\u20137.","DOI":"10.1128\/AAC.49.5.2002-2007.2005"},{"key":"key\n\t\t\t\t20171010172621_B4","doi-asserted-by":"crossref","unstructured":"Filipe SR, Severina E, Tomasz A. Distribution of the mosaic structured murM genes among natural populations of Streptococcus pneumoniae. J Bacteriol2000; 182: 6798\u2013805.","DOI":"10.1128\/JB.182.23.6798-6805.2000"},{"key":"key\n\t\t\t\t20171010172621_B5","doi-asserted-by":"crossref","unstructured":"Filipe SR, Severina E, Tomasz A. The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae. Proc Natl Acad Sci2002; 99: 1550\u20135.","DOI":"10.1073\/pnas.032671699"},{"key":"key\n\t\t\t\t20171010172621_B6","doi-asserted-by":"crossref","unstructured":"Smith AM, Klugman KP. Alterations in MurM, a cell wall muropeptide branching enzyme increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother2001; 45: 2393\u20136.","DOI":"10.1128\/AAC.45.8.2393-2396.2001"},{"key":"key\n\t\t\t\t20171010172621_B7","doi-asserted-by":"crossref","unstructured":"du Plessis M, Bingen E, Klugman KP. Analysis of penicillin-binding proteins genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin. Antimicrob Agents Chemother2002; 46: 2349\u201357.","DOI":"10.1128\/AAC.46.8.2349-2357.2002"},{"key":"key\n\t\t\t\t20171010172621_B8","doi-asserted-by":"crossref","unstructured":"Munoz R, Coffey TJ, Daniels M et al. Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis1991; 164: 302\u20136.","DOI":"10.1093\/infdis\/164.2.302"},{"key":"key\n\t\t\t\t20171010172621_B9","doi-asserted-by":"crossref","unstructured":"Dowson C, Hutchison A, Spratt BG. Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae. Mol Microbiol1989; 3: 95\u2013102.","DOI":"10.1111\/j.1365-2958.1989.tb00108.x"},{"key":"key\n\t\t\t\t20171010172621_B10","doi-asserted-by":"crossref","unstructured":"Chesnel L, Carapito R, Croize J et al. Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance. Antimicrob Agents Chemother2005; 49: 2895\u2013902.","DOI":"10.1128\/AAC.49.7.2895-2902.2005"},{"key":"key\n\t\t\t\t20171010172621_B11","doi-asserted-by":"crossref","unstructured":"Cafini F, del Campo R, Alou L et al. Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain. J Antimicrob Chemother2006; 57: 224\u20139.","DOI":"10.1093\/jac\/dki442"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/57\/5\/983\/2297506\/dkl083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T04:45:29Z","timestamp":1586753129000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jac\/article\/57\/5\/983\/764596\/Combinations-of-PBPs-and-MurM-protein-variants-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,13]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,3,13]]},"published-print":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkl083","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,5]]},"published":{"date-parts":[[2006,3,13]]}}}