{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:58:33Z","timestamp":1788461913414,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1093\/jac\/dkn319","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T00:25:25Z","timestamp":1218500725000},"page":"998-1002","source":"Crossref","is-referenced-by-count":35,"title":["Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design"],"prefix":"10.1093","volume":"62","author":[{"given":"Pragya","family":"Misra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvir","family":"Khaliq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"SenGupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Samant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awanish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Kushawaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. K.","family":"Majumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Narender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,11]]},"reference":[{"key":"key\n\t\t\t\t20170511114133_DKN319C1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1201-9712(00)90078-X","article-title":"Treatment of visceral leishmaniasis (kala-azar): a decade of progress and future approaches","volume":"4","author":"Murray","year":"2000","journal-title":"Int J Infect Dis"},{"key":"key\n\t\t\t\t20170511114133_DKN319C2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.1365-3156.2001.00754.x","article-title":"Monitoring drug resistance in leishmaniasis","volume":"6","author":"Croft","year":"2001","journal-title":"Trop Med Int Health"},{"key":"key\n\t\t\t\t20170511114133_DKN319C3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.febslet.2004.03.078","article-title":"Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani","volume":"565","author":"Das","year":"2004","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170511114133_DKN319C4","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1074\/jbc.M309341200","article-title":"Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity","volume":"279","author":"Mehta","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511114133_DKN319C5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.cdd.4400387","article-title":"The mitochondrion as an integrator\/coordinator of cell death pathways","volume":"5","author":"Kroemer","year":"1998","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170511114133_DKN319C6","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1074\/jbc.275.10.7087","article-title":"Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells","volume":"275","author":"Dey","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511114133_DKN319C7","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1016\/j.bmcl.2007.05.082","article-title":"A computational docking study for prediction of binding mode of diospyrin and derivatives: inhibitors of human and leishmanial DNA topoisomerase-I","volume":"17","author":"Chhabra","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"key\n\t\t\t\t20170511114133_DKN319C8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0020-7519(03)00008-0","article-title":"Programmed cell death in trypanosomatids and other unicellular organisms","volume":"33","author":"Debrabant","year":"2003","journal-title":"Int J Parasitol"},{"key":"key\n\t\t\t\t20170511114133_DKN319C9","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/AAC.48.3.852-859.2004","article-title":"Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes","volume":"48","author":"Paris","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170511114133_DKN319C10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000046884","article-title":"Mitochondria and apoptosis","volume":"10","author":"Gottlieb","year":"2001","journal-title":"Biol Signals Recept"},{"key":"key\n\t\t\t\t20170511114133_DKN319C11","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1021\/ci010025x","article-title":"How does consensus scoring work for virtual library screening? An idealized computer experiment","volume":"41","author":"Wang","year":"2001","journal-title":"J Chem Inf Comput Sci"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/62\/5\/998\/16862392\/dkn319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T05:50:19Z","timestamp":1503467419000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkn319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,11]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,8,11]]},"published-print":{"date-parts":[[2008,11]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkn319","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8,11]]}}}