{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:20:55Z","timestamp":1790014855059,"version":"4.0.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Antimicrobial Chemotherapy"],"published-print":{"date-parts":[[2009,9,1]]},"DOI":"10.1093\/jac\/dkp248","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T00:26:06Z","timestamp":1247790366000},"page":"579-588","source":"Crossref","is-referenced-by-count":60,"title":["Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation"],"prefix":"10.1093","volume":"64","author":[{"given":"S.","family":"Molina-Pinelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Soriano-Sarabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ferrando-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Resino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Munoz-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"issue":"16","key":"1_16185436","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1056\/NEJM199604183341602","volume":"334","author":"Collier","year":"1996","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"11","key":"2_5708862","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJM199709113371101","volume":"337","author":"Hammer","year":"1997","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"3_6421673","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1086\/315171","volume":"181","author":"Connick","year":"2000","journal-title":"The Journal of infectious diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"issue":"10","key":"4_18811360","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1086\/429670","volume":"191","author":"Benveniste","year":"2005","journal-title":"The Journal of infectious diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"issue":"20","key":"5_22620339","doi-asserted-by":"publisher","first-page":"10229","DOI":"10.1128\/JVI.00965-06","volume":"80","author":"Delobel","year":"2006","journal-title":"Journal of Virology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"issue":"2","key":"6_22421388","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.clim.2006.04.570","volume":"120","author":"Fernandez","year":"2006","journal-title":"Clinical immunology (Orlando, Fla.)","ISSN":"https:\/\/id.crossref.org\/issn\/1521-6616","issn-type":"print"},{"issue":"8","key":"7_17260733","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1086\/342695","volume":"35","author":"Dronda","year":"2002","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"issue":"8","key":"8_6073977","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1128\/JVI.72.8.6279-6282.1998","volume":"72","author":"Kaplan","year":"1998","journal-title":"Journal of Virology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"issue":"10","key":"9_11210621","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1097\/00002030-200107060-00018","volume":"15","author":"Pitrak","year":"2001","journal-title":"AIDS (London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"issue":"9","key":"10_17082271","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1097\/00002030-200206140-00013","volume":"16","author":"Hazenberg","year":"2002","journal-title":"AIDS (London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"issue":"2","key":"11_5881026","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nm0298-208","volume":"4","author":"Pakker","year":"1998","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"4","key":"12_10651891","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/79724","volume":"1","author":"Hazenberg","year":"2000","journal-title":"Nature immunology","ISSN":"https:\/\/id.crossref.org\/issn\/1529-2908","issn-type":"print"},{"issue":"3","key":"13_17376964","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/135965350200700304","volume":"7","author":"de la Rosa","year":"2002","journal-title":"Antiviral therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1359-6535","issn-type":"print"},{"issue":"4","key":"14_17835397","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/135965350300800404","volume":"8","author":"Ruiz-Mateos","year":"2003","journal-title":"Antiviral therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1359-6535","issn-type":"print"},{"issue":"3","key":"15_18186290","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1365-2249.2004.02474.x","volume":"136","author":"Ruiz-Mateos","year":"2004","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"12","key":"16_31289791","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1086\/588480","volume":"46","author":"Isgro","year":"2008","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"issue":"2","key":"17_18914984","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jcv.2004.09.030","volume":"33","author":"Molina-Pinelo","year":"2005","journal-title":"Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology","ISSN":"https:\/\/id.crossref.org\/issn\/1386-6532","issn-type":"print"},{"issue":"2","key":"18_6383642","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF02786467","volume":"20","author":"Ginaldi","year":"1999","journal-title":"Immunologic research","ISSN":"https:\/\/id.crossref.org\/issn\/0257-277X","issn-type":"print"},{"issue":"1","key":"19_18390235","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/IR:30:1:081","volume":"30","author":"Ginaldi","year":"2004","journal-title":"Immunologic research","ISSN":"https:\/\/id.crossref.org\/issn\/0257-277X","issn-type":"print"},{"issue":"2","key":"20_23481543","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/path.2104","volume":"211","author":"Gruver","year":"2007","journal-title":"The Journal of pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"issue":"17","key":"21_17338094","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1097\/00002030-200211220-00005","volume":"16","author":"Cohen Stuart","year":"2002","journal-title":"AIDS (London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"issue":"2","key":"22_31153442","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1189\/jlb.1207847","volume":"84","year":"2008","journal-title":"Journal of Leukocyte Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0741-5400","issn-type":"print"},{"issue":"6712","key":"23_6279853","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/25374","volume":"396","author":"Douek","year":"1998","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"2","key":"24_14195574","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2214\/ajr.149.2.269","volume":"149","author":"Choyke","year":"1987","journal-title":"American Journal of Roentgenology","ISSN":"https:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"issue":"10","key":"25_21331145","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1182\/blood.V99.10.3702","volume":"99","author":"Franco","year":"2002","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"16","key":"26_10440726","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1101\/gad.14.16.2060","volume":"14","author":"Wei","year":"2000","journal-title":"Genes & Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"4","key":"27_6139355","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0092-8674(00)81590-1","volume":"94","author":"Li","year":"1998","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"5","key":"28_31584057","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/QAI.0b013e31817bebb3","volume":"48","author":"Baker","year":"2008","journal-title":"Journal of acquired immune deficiency syndromes","ISSN":"https:\/\/id.crossref.org\/issn\/0894-9255","issn-type":"print"},{"key":"29_35284720","first-page":"583","volume":"7","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/1097-4180","issn-type":"print"},{"issue":"15","key":"30_11357672","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1097\/00002030-200110190-00007","volume":"15","author":"Correa","year":"2001","journal-title":"AIDS (London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"issue":"3","key":"31_23503214","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1086\/510746","volume":"44","author":"Moore","year":"2007","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"issue":"6","key":"32_10464126","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/archinte.133.3.401","volume":"133","author":"Grabar","year":"2000","journal-title":"Annals of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"issue":"9327","key":"33_17156489","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0140-6736(02)09411-4","volume":"360","author":"Egger","year":"2002","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"3","key":"34_17721208","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1468-1293.2003.00156.x","volume":"4","author":"Florence","year":"2003","journal-title":"HIV medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1464-2662","issn-type":"print"},{"issue":"2","key":"35_17665809","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/00126334-200306010-00002","volume":"33","author":"Anthony","year":"2003","journal-title":"Journal of acquired immune deficiency syndromes","ISSN":"https:\/\/id.crossref.org\/issn\/0894-9255","issn-type":"print"},{"issue":"3","key":"36_19252875","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1086\/431484","volume":"41","author":"Kaufmann","year":"2005","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"issue":"13","key":"37_22542114","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1097\/01.aids.0000242819.72839.db","volume":"20","author":"Marchetti","year":"2006","journal-title":"AIDS (London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/0269-9370","issn-type":"print"},{"issue":"2","key":"38_18081939","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1468-1293.2004.00187.x","volume":"5","author":"Hardy","year":"2004","journal-title":"HIV medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1464-2662","issn-type":"print"},{"issue":"1","key":"39_21328669","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1182\/blood.V95.1.249","volume":"95","author":"Hazenberg","year":"2000","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"10","key":"40_17607301","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1086\/374786","volume":"187","author":"Hunt","year":"2003","journal-title":"The Journal of infectious diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"issue":"4","key":"41_21334894","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1182\/blood-2003-09-3333","volume":"104","year":"2004","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"6831","key":"42_11117124","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/35073648","volume":"410","author":"McCune","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"7","key":"43_23102088","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1182\/blood-2006-09-047308","volume":"109","year":"2007","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"2","key":"44_19161965","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/00126334-200406010-00003","volume":"36","author":"Hansjee","year":"2004","journal-title":"Journal of acquired immune deficiency syndromes","ISSN":"https:\/\/id.crossref.org\/issn\/0894-9255","issn-type":"print"},{"issue":"3","key":"45_10859869","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/sj.cdd.4400491","volume":"6","author":"Verhoven","year":"1999","journal-title":"Cell death and differentiation","ISSN":"https:\/\/id.crossref.org\/issn\/1350-9047","issn-type":"print"},{"issue":"3","key":"46_10859864","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/sj.cdd.4400484","volume":"6","author":"Diaz","year":"1999","journal-title":"Cell death and differentiation","ISSN":"https:\/\/id.crossref.org\/issn\/1350-9047","issn-type":"print"},{"issue":"8","key":"47_17764328","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/S0531-5565(03)00090-1","volume":"38","author":"Weyand","year":"2003","journal-title":"Experimental gerontology","ISSN":"https:\/\/id.crossref.org\/issn\/0531-5565","issn-type":"print"},{"issue":"5","key":"48_28775085","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.exger.2006.12.003","volume":"42","author":"Appay","year":"2007","journal-title":"Experimental gerontology","ISSN":"https:\/\/id.crossref.org\/issn\/0531-5565","issn-type":"print"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/64\/3\/579\/2333223\/dkp248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T08:34:30Z","timestamp":1710491670000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkp248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,16]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,8,11]]},"published-print":{"date-parts":[[2009,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkp248","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,16]]}}}