{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:41:54Z","timestamp":1791294114693,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1093\/jac\/dkq083","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T01:10:43Z","timestamp":1269393043000},"page":"1224-1227","source":"Crossref","is-referenced-by-count":60,"title":["Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates"],"prefix":"10.1093","volume":"65","author":[{"given":"Smritilekha","family":"Bera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.","family":"Zhanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,3,23]]},"reference":[{"key":"key\n\t\t\t\t20170425164543_DKQ083C1","first-page":"11","article-title":"Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects","volume":"46","author":"Dzidic","year":"2008","journal-title":"Food Technol Biotech"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C2","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1021\/jm800345u","article-title":"Design, synthesis and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity","volume":"51","author":"Bera","year":"2008","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C3","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C4","doi-asserted-by":"crossref","first-page":"15997","DOI":"10.1073\/pnas.0606129103","article-title":"Ultrashort antibacterial and antifungal lipopeptides","volume":"103","author":"Makovitski","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.copbio.2008.10.013","article-title":"De novo designed synthetic mimics of antimicrobial peptides","volume":"19","author":"Scott","year":"2008","journal-title":"Curr Opin Biotechnol"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1099\/mic.0.27526-0","article-title":"Evidence of a charge-density threshold for optimum efficiency of biocidal cationic surfaces","volume":"151","author":"K\u00fcgler","year":"2005","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2672.2005.02664.x","article-title":"Cationic antiseptics: diversity of action under a common epithet","volume":"99","author":"Gilbert","year":"2005","journal-title":"J Appl Microbiol"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C8","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1021\/jo001142e","article-title":"Synthesis and anti HIV activity of guanidino aminoglycosides","volume":"65","author":"Baker","year":"2000","journal-title":"J Org Chem"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C9","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1128\/AAC.01538-07","article-title":"Antimicrobial resistant pathogens in intensive care units across Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005\/2006","volume":"52","author":"Zhanel","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425164543_DKQ083C10","doi-asserted-by":"crossref","first-page":"12612","DOI":"10.1021\/bi960835f","article-title":"Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes","volume":"35","author":"Dathe","year":"1996","journal-title":"Biochemistry"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/65\/6\/1224\/13760033\/dkq083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T10:21:06Z","timestamp":1503483666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkq083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,23]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,3,23]]},"published-print":{"date-parts":[[2010,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkq083","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3,23]]}}}