{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:10:17Z","timestamp":1790939417079,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1093\/jac\/dkq387","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T01:54:34Z","timestamp":1290477274000},"page":"15-28","source":"Crossref","is-referenced-by-count":47,"title":["Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181"],"prefix":"10.1093","volume":"66","author":[{"given":"Gallen B.","family":"Triana-Baltzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hedlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Aschenbrenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,21]]},"reference":[{"key":"key\n\t\t\t\t20170425183809_DKQ387C1","volume-title":"Seasonal Influenza Factsheet","author":"WHO"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C2","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1001\/jama.2009.294","article-title":"Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States","volume":"301","author":"Dharan","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1001\/jama.297.13.1435","article-title":"Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors","volume":"297","author":"Hatakeyama","year":"2007","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C4","first-page":"119","article-title":"Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine","volume":"176","author":"Hayden","year":"1992","journal-title":"Curr Top Microbiol Immunol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C5","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1056\/NEJMp058291","article-title":"Oseltamivir resistance\u2014disabling our influenza defenses","volume":"353","author":"Moscona","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza","volume":"360","author":"Moscona","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C7","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AAC.00555-08","article-title":"Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008","volume":"52","author":"Sheu","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10156-003-0262-6","article-title":"Emergence of amantadine-resistant influenza A viruses: epidemiological study","volume":"9","author":"Suzuki","year":"2003","journal-title":"J Infect Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C9","first-page":"433","article-title":"Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009","volume":"58","author":"CDC","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.324_705","article-title":"Swine flu outbreak. What role for antiviral drugs?","volume":"324","author":"Couzin-Frankel","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3810\/pgm.2009.09.2051","article-title":"The first pandemic of the 21st century: a review of the 2009 pandemic variant influenza A (H1N1) virus","volume":"121","author":"Scalera","year":"2009","journal-title":"Postgrad Med"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1086\/522609","article-title":"DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection","volume":"196","author":"Belser","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C13","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1128\/AAC.00389-09","article-title":"DAS181 inhibits H5N1 influenza virus infection of human lung tissues","volume":"53","author":"Chan","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C14","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/AAC.50.4.1470-1479.2006","article-title":"Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection","volume":"50","author":"Malakhov","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C15","doi-asserted-by":"crossref","first-page":"e7838","DOI":"10.1371\/journal.pone.0007838","article-title":"Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein","volume":"4","author":"Triana-Baltzer","year":"2009","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C16","doi-asserted-by":"crossref","first-page":"e7788","DOI":"10.1371\/journal.pone.0007788","article-title":"Novel pandemic influenza A(H1N1) viruses are potently inhibited by DAS181, a sialidase fusion protein","volume":"4","author":"Triana-Baltzer","year":"2009","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jac\/dkp421","article-title":"DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis","volume":"65","author":"Triana-Baltzer","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/AAC.40.1.40","article-title":"Generation and characterization of variants of NWS\/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en","volume":"40","author":"McKimm-Breschkin","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/AAC.17.5.865","article-title":"Plaque inhibition assay for drug susceptibility testing of influenza viruses","volume":"17","author":"Hayden","year":"1980","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C20","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s007050170002","article-title":"Universal primer set for the full-length amplification of all influenza A viruses","volume":"146","author":"Hoffmann","year":"2001","journal-title":"Arch Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C21","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/JVI.67.6.2972-2980.1993","article-title":"Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase","volume":"67","author":"Colman","year":"1993","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0042-6822(03)00068-0","article-title":"X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus","volume":"309","author":"Ha","year":"2003","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C23","doi-asserted-by":"crossref","first-page":"16874","DOI":"10.1073\/pnas.0708363104","article-title":"Structural basis for receptor specificity of influenza B virus hemagglutinin","volume":"104","author":"Wang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C24","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/pro.5560040606","article-title":"Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase","volume":"4","author":"Varghese","year":"1995","journal-title":"Protein Sci"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C25","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano","year":"2002"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C26","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1099\/0022-1317-83-11-2683","article-title":"A release-competent influenza A virus mutant lacking the coding capacity for the neuraminidase active site","volume":"83","author":"Gubareva","year":"2002","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C27","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1128\/JVI.73.8.6743-6751.1999","article-title":"Amino acid residues contributing to the substrate specificity of the influenza A virus neuraminidase","volume":"73","author":"Kobasa","year":"1999","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C28","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1128\/AAC.47.7.2264-2272.2003","article-title":"Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir","volume":"47","author":"McKimm-Breschkin","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C29","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/JVI.74.18.8502-8512.2000","article-title":"Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals","volume":"74","author":"Matrosovich","year":"2000","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.biochem.69.1.531","article-title":"Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin","volume":"69","author":"Skehel","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/prot.340060402","article-title":"The neuraminidase of influenza virus","volume":"6","author":"Air","year":"1989","journal-title":"Proteins"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C32","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1073\/pnas.0801259105","article-title":"Contemporary North American influenza H7 viruses possess human receptor specificity: implications for virus transmissibility","volume":"105","author":"Belser","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1743-422X-4-42","article-title":"Receptor binding specificity of recent human H3N2 influenza viruses","volume":"4","author":"Kumari","year":"2007","journal-title":"Virol J"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C34","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jmb.2005.11.002","article-title":"Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities","volume":"355","author":"Stevens","year":"2006","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1124513","article-title":"Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus","volume":"312","author":"Stevens","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C36","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jmb.2008.04.016","article-title":"Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity","volume":"381","author":"Stevens","year":"2008","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C37","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1128\/JCM.43.8.4139-4146.2005","article-title":"Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor","volume":"43","author":"Hatakeyama","year":"2005","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C38","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1128\/JVI.77.15.8418-8425.2003","article-title":"Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors","volume":"77","author":"Matrosovich","year":"2003","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/viro.1999.0058","article-title":"In vitro selection and characterisation of influenza B\/Beijing\/1\/87 isolates with altered susceptibility to zanamivir","volume":"265","author":"Barnett","year":"1999","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-3542(03)00011-1","article-title":"A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding","volume":"59","author":"Baum","year":"2003","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.antiviral.2006.10.012","article-title":"Characterization of drug-resistant recombinant influenza A\/H1N1 viruses selected in vitro with peramivir and zanamivir","volume":"74","author":"Baz","year":"2007","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/viro.1995.0058","article-title":"Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en","volume":"214","author":"Blick","year":"1995","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/viro.1998.9194","article-title":"The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en","volume":"246","author":"Blick","year":"1998","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.antiviral.2004.04.004","article-title":"In vitro generation and characterisation of an influenza B variant with reduced sensitivity to neuraminidase inhibitors","volume":"63","author":"Cheam","year":"2004","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.virusres.2007.07.010","article-title":"Characterization of human H1N1 influenza virus variants selected in vitro with zanamivir in the presence of sialic acid-containing molecules","volume":"129","author":"Giannecchini","year":"2007","journal-title":"Virus Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C46","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1128\/JVI.70.3.1818-1827.1996","article-title":"Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en","volume":"70","author":"Gubareva","year":"1996","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C47","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/JVI.71.5.3385-3390.1997","article-title":"Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en","volume":"71","author":"Gubareva","year":"1997","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C48","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1128\/JVI.72.3.2456-2462.1998","article-title":"Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors","volume":"72","author":"McKimm-Breschkin","year":"1998","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C49","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1128\/JVI.76.11.5380-5386.2002","article-title":"In vitro selection and characterization of influenza A (A\/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675","volume":"76","author":"Molla","year":"2002","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C50","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1086\/339358","article-title":"Accumulation of defective neuraminidase (NA) genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA","volume":"185","author":"Nedyalkova","year":"2002","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0166-3542(01)00168-1","article-title":"Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201","volume":"52","author":"Smee","year":"2001","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C52","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1128\/AAC.42.12.3234","article-title":"Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071","volume":"42","author":"Tai","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C53","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1128\/AAC.46.12.3809-3816.2002","article-title":"Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir","volume":"46","author":"Wang","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C54","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/jama.2009.297","article-title":"Morbidity and mortality associated with nosocomial transmission of oseltamivir-resistant influenza A(H1N1) virus","volume":"301","author":"Gooskens","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C55","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.2165\/11531450-000000000-00000","article-title":"Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses","volume":"69","author":"Hurt","year":"2009","journal-title":"Drugs"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nbt1375","article-title":"Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin","volume":"26","author":"Chandrasekaran","year":"2008","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C57","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature05264","article-title":"Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors","volume":"444","author":"Yamada","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1006\/viro.1993.1276","article-title":"Selection and characterization of a neuraminidase-minus mutant of influenza virus and its rescue by cloned neuraminidase genes","volume":"194","author":"Liu","year":"1993","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/viro.1996.8421","article-title":"Hemagglutinin specificity and neuraminidase coding capacity of neuraminidase-deficient influenza viruses","volume":"229","author":"Yang","year":"1997","journal-title":"Virology"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C60","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/AAC.42.4.801","article-title":"Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140","volume":"42","author":"Bantia","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0166-3542(01)00124-3","article-title":"Position statement: global neuraminidase inhibitor susceptibility network","volume":"49","author":"Zambon","year":"2001","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20170425183809_DKQ387C62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1099-1654(200001\/02)10:1<45::AID-RMV265>3.0.CO;2-R","article-title":"Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors","volume":"10","author":"Tisdale","year":"2000","journal-title":"Rev Med Virol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/66\/1\/15\/13760175\/dkq387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T01:08:28Z","timestamp":1592096908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkq387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,21]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,11,21]]},"published-print":{"date-parts":[[2011,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkq387","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11,21]]}}}