{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:51:23Z","timestamp":1790077883403,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1093\/jac\/dkr375","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T20:53:48Z","timestamp":1316638428000},"page":"715-722","source":"Crossref","is-referenced-by-count":267,"title":["The Deferasirox\u2013AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial"],"prefix":"10.1093","volume":"67","author":[{"given":"Brad","family":"Spellberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf S.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Chin-Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Perfect","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fredricks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P.","family":"Brass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"key\n\t\t\t\t20170425170714_DKR375C1","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1172\/JCI32338","article-title":"The iron chelator deferasirox protects mice from mucormycosis through iron starvation","volume":"117","author":"Ibrahim","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425170714_DKR375C2","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI42164","article-title":"The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice","volume":"120","author":"Liu","year":"2010","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425170714_DKR375C3","first-page":"1507","article-title":"Mucormycosis in diabetic ketoacidosis. Role of unbound iron binding capacity of transferrin","volume":"36","author":"Abe","year":"1986","journal-title":"Acta Pathol Jpn"},{"key":"key\n\t\t\t\t20170425170714_DKR375C4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2337\/diacare.31.12.1109","article-title":"A mechanism of susceptibility to mucormycosis in diabetic ketoacidosis: transferrin and iron availability","volume":"31","author":"Artis","year":"1982","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170425170714_DKR375C5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0272-6386(87)80015-X","article-title":"Intestinal mucormycosis in hemodialysis patients following deferoxamine","volume":"10","author":"Eiser","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.7326\/0003-4819-107-5-678","article-title":"Fatal Rhizopus infections in hemodialysis patients receiving deferoxamine","volume":"107","author":"Windus","year":"1987","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20170425170714_DKR375C7","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0002-9343(89)80836-8","article-title":"Mucormycosis: association with deferoxamine therapy","volume":"87","author":"Daly","year":"1989","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t20170425170714_DKR375C8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0272-6386(12)80606-8","article-title":"Deferoxamine therapy and mucormycosis in dialysis patients: report of an international registry","volume":"18","author":"Boelaert","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C9","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI116419","article-title":"Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies","volume":"91","author":"Boelaert","year":"1993","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170425170714_DKR375C10","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/0006-2952(94)90314-X","article-title":"Iron uptake from ferrioxamine and from ferrirhizoferrin by germinating spores of Rhizopus microsporus","volume":"47","author":"de Locht","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170425170714_DKR375C11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/infdis\/169.1.231","article-title":"The effect of deferoxamine on different zygomycetes","volume":"169","author":"Boelaert","year":"1994","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ki.1994.89","article-title":"Deferoxamine augments growth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect","volume":"45","author":"Boelaert","year":"1994","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170425170714_DKR375C13","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ki.1989.301","article-title":"Effects of deferoxamine, feroxamine and iron on experimental mucormycosis (zygomycosis)","volume":"36","author":"Van Cutsem","year":"1989","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170425170714_DKR375C14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00446996","article-title":"Effects of iron and desferrioxamine on Rhizopus infection","volume":"110","author":"Abe","year":"1990","journal-title":"Mycopathologia"},{"key":"key\n\t\t\t\t20170425170714_DKR375C15","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/jac\/dkl350","article-title":"Deferiprone iron chelation as a novel therapy for experimental mucormycosis","volume":"58","author":"Ibrahim","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170425170714_DKR375C16","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1073\/pnas.0709578105","article-title":"Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis","volume":"105","author":"Chamilos","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170425170714_DKR375C17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.beha.2004.09.002","article-title":"Iron-chelating therapy with the new oral agent ICL670 (Exjade)","volume":"18","author":"Cappellini","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"key\n\t\t\t\t20170425170714_DKR375C18","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/AAC.01065-06","article-title":"Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis","volume":"50","author":"Reed","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425170714_DKR375C19","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1128\/AAC.00361-09","article-title":"Safety and outcomes of open-label deferasirox iron chelation therapy for mucormycosis","volume":"53","author":"Spellberg","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425170714_DKR375C20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/590004","article-title":"Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis","volume":"47","author":"Chamilos","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C22","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1086\/599105","article-title":"Recent advances in the management of mucormycosis: from bench to bedside","volume":"48","author":"Spellberg","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: a review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/13693780903311944","article-title":"Primary treatment of zygomycosis with liposomal amphotericin B: analysis of 28 cases","volume":"48","author":"Shoham","year":"2010","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20170425170714_DKR375C25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.eimc.2010.09.008","article-title":"Mortality risk factors in patients with zygomycosis: a retrospective and multicentre study of 25 cases","volume":"29","author":"Llorente","year":"2011","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"key\n\t\t\t\t20170425170714_DKR375C26","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(03)13309-0","article-title":"Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial","volume":"361","author":"Nisbet-Brown","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170425170714_DKR375C27","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3201\/eid1509.090334","article-title":"Increasing incidence of zygomycosis (mucormycosis), France, 1997\u20132006","volume":"15","author":"Bitar","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/pgmj.2008.076463","article-title":"Invasive zygomycosis in India: experience in a tertiary care hospital","volume":"85","author":"Chakrabarti","year":"2009","journal-title":"Postgrad Med J"},{"key":"key\n\t\t\t\t20170425170714_DKR375C29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/jinf.2001.0831","article-title":"Ten years\u2019 experience in zygomycosis at a tertiary care centre in India","volume":"42","author":"Chakrabarti","year":"2001","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20170425170714_DKR375C30","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1128\/AAC.47.10.3343-3344.2003","article-title":"Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae","volume":"47","author":"Ibrahim","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170425170714_DKR375C31","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1086\/605445","article-title":"Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome","volume":"200","author":"Singh","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170425170714_DKR375C32","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1080\/10428190310001653691","article-title":"Improved outcome of zygomycosis in patients with hematological diseases?","volume":"45","author":"Gleissner","year":"2004","journal-title":"Leuk Lymphoma"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/67\/3\/715\/13762212\/dkr375.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T12:28:44Z","timestamp":1503491324000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkr375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,20]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,9,20]]},"published-print":{"date-parts":[[2012,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkr375","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13357283.793453065","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13357283.14742080","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13357283.14726664","asserted-by":"object"}]},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9,20]]}}}