{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:23:06Z","timestamp":1790518986531,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1093\/jac\/dkt334","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T20:19:54Z","timestamp":1377375594000},"page":"139-149","source":"Crossref","is-referenced-by-count":27,"title":["Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival"],"prefix":"10.1093","volume":"69","author":[{"given":"Maria Adelaida","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Navas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Jimena","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deninson Alejandro","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Manuel","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zilberstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Gore","family":"Saravia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,8,24]]},"reference":[{"key":"key\n\t\t\t\t20170511115815_DKT334C1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/IAI.68.1.288-293.2000","article-title":"Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis","volume":"68","author":"Murray","year":"2000","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511115815_DKT334C2","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1128\/IAI.68.11.6289-6293.2000","article-title":"Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment","volume":"68","author":"Murray","year":"2000","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511115815_DKT334C3","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/315890","article-title":"Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis","volume":"182","author":"Murray","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511115815_DKT334C4","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1128\/IAI.70.12.6734-6740.2002","article-title":"Up-regulation of Th1-type responses in mucosal leishmaniasis patients","volume":"70","author":"Bacellar","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511115815_DKT334C5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1086\/653829","article-title":"T-bet, GATA-3, and Foxp3 expression and Th1\/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species","volume":"202","author":"Diaz","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511115815_DKT334C6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The relationship between leishmaniasis and AIDS: the second 10 years","volume":"21","author":"Alvar","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170511115815_DKT334C7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1086\/503371","article-title":"Resistance to antimony and treatment failure in human Leishmania (Viannia) infection","volume":"193","author":"Rojas","year":"2006","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511115815_DKT334C8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2307\/3285647","article-title":"Sensitivity to Glucantime of Leishmania viannia isolated from patients prior to treatment","volume":"85","author":"Robledo","year":"1999","journal-title":"J Parasitol"},{"key":"key\n\t\t\t\t20170511115815_DKT334C9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4269\/ajtmh.1990.43.464","article-title":"Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania ssp. from patients unresponsive to pentavalent antimony therapy","volume":"43","author":"Jackson","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170511115815_DKT334C10","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1086\/510860","article-title":"Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate","volume":"195","author":"Cruz","year":"2007","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170511115815_DKT334C11","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1128\/AAC.01196-07","article-title":"Inhibition of ABC transporters abolishes antimony resistance in Leishmania infection","volume":"52","author":"Mookerjee Basu","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C12","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1128\/JCM.00216-12","article-title":"Novel approach to in vitro drug susceptibility assessment of clinical strains of Leishmania spp","volume":"50","author":"Fernandez","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170511115815_DKT334C13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-6851(00)00270-X","article-title":"Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models","volume":"110","author":"Roy","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"key\n\t\t\t\t20170511115815_DKT334C14","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/nar\/gkm049","article-title":"The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase","volume":"35","author":"Yu","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170511115815_DKT334C15","doi-asserted-by":"crossref","first-page":"e31752","DOI":"10.1371\/journal.pone.0031752","article-title":"Genome-wide RNAi screen in IFN-\u03b3-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170511115815_DKT334C16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170511115815_DKT334C17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nature05125","article-title":"Identification of a mammalian mitochondrial porphyrin transporter","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170511115815_DKT334C18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/toxsci\/kfr008","article-title":"The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic cytotoxicity","volume":"120","author":"Chavan","year":"2011","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170511115815_DKT334C19","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1021\/bi700015m","article-title":"Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane","volume":"46","author":"Paterson","year":"2007","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170511115815_DKT334C20","doi-asserted-by":"crossref","first-page":"C579","DOI":"10.1152\/ajpcell.00612.2006","article-title":"Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6","volume":"294","author":"Jalil","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170511115815_DKT334C21","doi-asserted-by":"crossref","first-page":"e37378","DOI":"10.1371\/journal.pone.0037378","article-title":"Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes","volume":"7","author":"Kiss","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170511115815_DKT334C22","doi-asserted-by":"crossref","first-page":"M110.006403","DOI":"10.1074\/mcp.M110.006403","article-title":"Classification of subcellular location by comparative proteomic analysis of native and density-shifted lysosomes","volume":"10","author":"Della Valle","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"key\n\t\t\t\t20170511115815_DKT334C23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host\u2013pathogen interface","volume":"9","author":"Kaye","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20170511115815_DKT334C24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/jac\/dkg224","article-title":"Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy","volume":"51","author":"Van Bambeke","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/jac\/dkg225","article-title":"Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics","volume":"51","author":"Van Bambeke","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/jac\/dkh487","article-title":"The intracellular pharmacology of antiretroviral protease inhibitors","volume":"54","author":"Ford","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C27","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1128\/AAC.01724-09","article-title":"Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila","volume":"54","author":"Lemaire","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C28","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbrc.2004.08.002","article-title":"Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9","volume":"322","author":"Bhattacharjee","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170511115815_DKT334C29","doi-asserted-by":"crossref","first-page":"37423","DOI":"10.1074\/jbc.M506439200","article-title":"Redox imbalance in cystine\/glutamate transporter-deficient mice","volume":"280","author":"Sato","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511115815_DKT334C30","doi-asserted-by":"crossref","first-page":"22244","DOI":"10.1074\/jbc.M110.121327","article-title":"System xc\u2212 and thioredoxin reductase 1 cooperatively rescue glutathione deficiency","volume":"285","author":"Mandal","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511115815_DKT334C31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1023\/A:1022823605068","article-title":"Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione","volume":"16","author":"Ferreira Cdos","year":"2003","journal-title":"Biometals"},{"key":"key\n\t\t\t\t20170511115815_DKT334C32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0009-2797(92)90057-R","article-title":"Arsenic induces and enhances rat hepatic metallothionein production in vivo","volume":"85","author":"Albores","year":"1992","journal-title":"Chem Biol Interact"},{"key":"key\n\t\t\t\t20170511115815_DKT334C33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10534-010-9351-z","article-title":"Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs","volume":"23","author":"Sabolic","journal-title":"Biometals"},{"key":"key\n\t\t\t\t20170511115815_DKT334C34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0300-483X(00)00194-3","article-title":"Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I\/II null mice","volume":"147","author":"Liu","year":"2000","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170511115815_DKT334C35","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/toxsci\/55.2.460","article-title":"Metallothionein-I\/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals","volume":"55","author":"Liu","year":"2000","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170511115815_DKT334C36","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/IAI.01320-07","article-title":"Comparison of the effects of Leishmania major or Leishmania donovani infection on macrophage gene expression","volume":"76","author":"Gregory","year":"2008","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170511115815_DKT334C37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1128\/AAC.01183-07","article-title":"Modulation of gene expression in human macrophages treated with the anti-Leishmania pentavalent antimonial drug sodium stibogluconate","volume":"52","author":"El Fadili","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170511115815_DKT334C38","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1182\/blood-2002-10-3232","article-title":"Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites","volume":"102","author":"Chaussabel","year":"2003","journal-title":"Blood"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/69\/1\/139\/16864112\/dkt334.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T20:09:31Z","timestamp":1563739771000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkt334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,24]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,8,24]]},"published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkt334","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8,24]]}}}