{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:41:35Z","timestamp":1790055695063,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1093\/jac\/dku080","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T02:41:40Z","timestamp":1397184100000},"page":"1834-1843","source":"Crossref","is-referenced-by-count":107,"title":["Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery"],"prefix":"10.1093","volume":"69","author":[{"given":"Astha","family":"Nautiyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Neelakanteshwar","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Muniyappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"key\n\t\t\t\t20170522212131_DKU080C1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/493014a","article-title":"Infectious disease: TB's revenge","volume":"493","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522212131_DKU080C2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09657","article-title":"The challenge of new drug discovery for tuberculosis","volume":"469","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522212131_DKU080C3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/10409230701260258","article-title":"Regulation of bacterial RecA protein function","volume":"42","year":"2007","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1128\/JB.160.1.112-121.1984","article-title":"Measurement of in vivo expression of the recA gene of Escherichia coli by using lacZ gene fusions","volume":"160","year":"1984","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2958.2002.03199.x","article-title":"DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA","volume":"46","year":"2002","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/10409238.2010.480968","article-title":"A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V","volume":"45","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C7","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/MMBR.00020-08","article-title":"RecBCD enzyme and the repair of double-stranded DNA breaks","volume":"72","year":"2008","journal-title":"Microbiol Mol Biol Rev"},{"key":"key\n\t\t\t\t20170522212131_DKU080C8","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1128\/JB.180.7.1955-1958.1998","article-title":"Frequency of pilin antigenic variation in Neisseria gonorrhoeae.","volume":"180","year":"1998","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3201\/eid0605.000503","article-title":"Toxin gene expression by shiga toxin producing Escherichia coli: the role of antibiotics and the bacterial SOS response","volume":"6","year":"2000","journal-title":"Emerging Infect Dis"},{"key":"key\n\t\t\t\t20170522212131_DKU080C10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7007-5-14","article-title":"A novel role for RecA under non-stress: promotion of swarming motility in Escherichia coli K-12","volume":"5","year":"2007","journal-title":"BMC Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/AAC.50.1.171-177.2006","article-title":"Ciprofloxacin and trimethoprim cause phage induction and virulence modulation in Staphylococcus aureus","volume":"50","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170522212131_DKU080C12","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1128\/JB.00732-09","article-title":"Stress induced \u03b2-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome","volume":"191","year":"2009","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/10409230701597741","article-title":"Controlling mutation: intervening in evolution as a therapeutic strategy","volume":"42","year":"2007","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C14","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1371\/journal.pbio.0030176","article-title":"Inhibition of mutation and combating the evolution of antibiotic resistance","volume":"3","year":"2005","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C15","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/JB.02176-12","article-title":"Antibiotic resistance acquired through a DNA damage-inducible response in Acinetobacter baumannii","volume":"195","year":"2013","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C16","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1126\/science.1101630","article-title":"SOS response induction by \u03b2-lactams and bacterial defense against antibiotic lethality","volume":"305","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522212131_DKU080C17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2180-8-120","article-title":"Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant","volume":"8","year":"2008","journal-title":"BMC Microbiol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C18","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1128\/AAC.00168-10","article-title":"Impact of recA on levofloxacin exposure-related resistance development","volume":"54","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170522212131_DKU080C19","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1016\/S0264-410X(03)00434-1","article-title":"A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability","volume":"21","year":"2003","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170522212131_DKU080C20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1471-2180-8-234","article-title":"Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance","volume":"8","year":"2008","journal-title":"BMC Microbiol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C21","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1016\/j.bmcl.2007.04.013","article-title":"Directed molecular screening for RecA ATPase inhibitors","volume":"17","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"key\n\t\t\t\t20170522212131_DKU080C22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.pa.35.040195.000521","article-title":"Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis","volume":"35","year":"1995","journal-title":"Annu Rev Pharmacol Ther"},{"key":"key\n\t\t\t\t20170522212131_DKU080C23","first-page":"2239","article-title":"Suramin: a novel antineoplastic agent with multiple potential mechanisms of action","volume":"53","year":"1993","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170522212131_DKU080C24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0031-6997(25)00445-4","article-title":"Recent research on the biological activity of suramin","volume":"45","year":"1993","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20170522212131_DKU080C25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1476-5381.1988.tb11427.x","article-title":"Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens","volume":"93","year":"1988","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C26","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0026-895X(25)08769-3","article-title":"Suramin analogues as subtype-selective G protein inhibitors","volume":"49","year":"1996","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C27","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1021\/bi9819125","article-title":"RecA protein of Mycobacterium tuberculosis possesses pH-dependent DNA pairing and strand exchange activities: implications for allele exchange in mycobacteria","volume":"38","year":"1999","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170522212131_DKU080C28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/prot.10433","article-title":"The Mycobacterium smegmatis RecA protein is structurally similar but functionally distinct from Mycobacterium tuberculosis RecA","volume":"53","year":"2003","journal-title":"Proteins"},{"key":"key\n\t\t\t\t20170522212131_DKU080C29","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1021\/bi902021d","article-title":"Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and non-cognate RecA proteins","volume":"49","year":"2010","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170522212131_DKU080C30","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1099\/00221287-143-3-929","article-title":"Characterization of Mycobacterium tuberculosis LexA: recognition of a Cheo (Bacillus-type SOS) box","volume":"143","year":"1997","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20170522212131_DKU080C31","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1021\/bi00152a044","article-title":"Nature of the interaction of growth factors with suramin","volume":"31","year":"1992","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170522212131_DKU080C32","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1073\/pnas.89.7.3025","article-title":"Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells","volume":"89","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170522212131_DKU080C33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1021\/bi1018013","article-title":"DNA-binding, coprotease and strand exchange activities of mycobacterial RecA proteins: implications for functional diversity among RecA nucleoprotein filaments","volume":"50","year":"2011","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170522212131_DKU080C34","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature09200","article-title":"Structure of the LexA-DNA complex and implications for SOS box measurement","volume":"466","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522212131_DKU080C35","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1529\/biophysj.104.045567","article-title":"Direct observation of the assembly of RecA\/DNA complexes by atomic force microscopy","volume":"87","year":"2004","journal-title":"Biophys J"},{"key":"key\n\t\t\t\t20170522212131_DKU080C36","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1128\/JB.185.14.4280-4284.2003","article-title":"Crystal structures of the Mycobacterium smegmatis RecA and its nucleotide complexes","volume":"185","year":"2003","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C37","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jmb.2007.01.058","article-title":"Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA","volume":"367","year":"2007","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C38","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/MCB.21.3.966-976.2001","article-title":"Molecular dissection of interactions between Rad51 and members of the recombination-repair group","volume":"21","year":"2001","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/cb100428c","article-title":"Identification of specific inhibitors of human Rad51 recombinase using high-throughput screening","volume":"6","year":"2011","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2958.1997.5731934.x","article-title":"SOS induction in mycobacteria: analysis of the DNA-binding activity of a LexA-like repressor and its role in DNA damage induction of the recA gene from Mycobacterium smegmatis","volume":"26","year":"1997","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C41","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1128\/AAC.00033-11","article-title":"Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis","volume":"55","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170522212131_DKU080C42","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1128\/JB.180.20.5473-5477.1998","article-title":"Characterization of the mIHF gene of Mycobacterium smegmatis","volume":"180","year":"1998","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C43","first-page":"467869","article-title":"Hepatitis C virus NS3 inhibitors: current and future perspectives","volume":"2013","year":"2013","journal-title":"Biomed Res Int"},{"key":"key\n\t\t\t\t20170522212131_DKU080C44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-pharmtox-010611-134639","article-title":"Chemical genetics-based target identification in drug discovery","volume":"52","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t20170522212131_DKU080C45","doi-asserted-by":"crossref","first-page":"e10069","DOI":"10.1371\/journal.pone.0010069","article-title":"A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine","volume":"5","year":"2010","journal-title":"PLoS One"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:12:21Z","timestamp":1746180741000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dku080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,4,9]]},"published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dku080","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}