{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:18:22Z","timestamp":1785806302474,"version":"3.56.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>All clinical isolates of group B Streptococcus (GBS; Streptococcus agalactiae) are considered uniformly susceptible to \u03b2-lactams, including penicillins. However, GBS with reduced penicillin susceptibility (PRGBS) were first identified by our group in Japan and have also been reported from North America. PRGBS are non-susceptible to penicillin because of acquisition of amino acid substitutions near the conserved active-site motifs in PBP2X. In particular, V405A and Q557E are considered the key amino acid substitutions responsible for penicillin non-susceptibility. We revealed that in addition to the substitutions in PBP2X, an amino acid substitution in PBP1A confers high-level cephalosporin resistance in GBS. As the number of publications on GBS with reduced \u03b2-lactam susceptibility (GBS-RBS), especially PRGBS, and concomitantly the need for a systematic classification of GBS-RBS is increasing, we propose here a classification of GBS-RBS based on the amino acid substitutions in their PBPs.<\/jats:p>","DOI":"10.1093\/jac\/dkv022","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T04:16:05Z","timestamp":1423541765000},"page":"1601-1603","source":"Crossref","is-referenced-by-count":35,"title":["Classification of group B streptococci with reduced \u03b2-lactam susceptibility (GBS-RBS) based on the amino acid substitutions in PBPs"],"prefix":"10.1093","volume":"70","author":[{"given":"Kouji","family":"Kimura","sequence":"first","affiliation":[{"name":"1 \u00a0Department of Bacteriology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nagano","sequence":"additional","affiliation":[{"name":"2 \u00a0Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshichika","family":"Arakawa","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Bacteriology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"2022020123122931200_DKV022C1","first-page":"222","article-title":"Group B streptococcal infections","volume-title":"Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular 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