{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:15:52Z","timestamp":1776510952832,"version":"3.51.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Streptococcus agalactiae constitutes an important cause of neonatal infections in sub-Saharan Africa. Sulfadoxine\/pyrimethamine\u2014the current intermittent preventive treatment of malaria in pregnancy (IPTp)\u2014has proven in vitro activity against group B Streptococcus (GBS). Because of specific drug resistance to sulfadoxine\/pyrimethamine, mefloquine\u2014an antimalarial without in vitro activity against GBS\u2014was evaluated as a potential alternative. This study assessed the potential of sulfadoxine\/pyrimethamine-IPTp to reduce the prevalence of GBS colonization in pregnant women in Gabon when compared with the inactive control mefloquine-IPTp.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Pregnant women participating in a randomized controlled clinical trial evaluating mefloquine-IPTp versus sulfadoxine\/pyrimethamine-IPTp were invited to participate and recto-vaginal swabs were collected at delivery for detection of GBS colonization. Prevalence of recto-vaginal GBS colonization was compared between IPTp regimens and risk factor and birth outcome analyses were computed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 549 participants, 106 were positive for GBS colonization at delivery (19%; 95% CI\u200a=\u200a16%\u201323%). Prevalence of maternal GBS colonization showed no significant difference between the two IPTp regimens (mefloquine-IPTp: 67 of 366 women\u200a=\u200a18%; 95% CI\u200a=\u200a14%\u201322%; sulfadoxine\/pyrimethamine-IPTp: 39 of 183 women\u200a=\u200a21%; 95% CI\u200a=\u200a15%\u201327%). Risk factor analysis for GBS colonization demonstrated a significant association with illiteracy (adjusted OR\u200a=\u200a2.03; 95% CI\u200a=\u200a1.25\u20133.30). GBS colonization had no impact on birth outcome, anaemia at delivery, gestational age and birth weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sulfadoxine\/pyrimethamine did not reduce colonization rates when used as the IPTp drug during pregnancy. Illiteracy was associated with GBS colonization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkv041","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T01:57:20Z","timestamp":1425002240000},"page":"1898-1902","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of intermittent preventive treatment of malaria against group B <i>Streptococcus<\/i> colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine\/pyrimethamine versus mefloquine"],"prefix":"10.1093","volume":"70","author":[{"given":"Mesk\u00fcre","family":"Capan-Melser","sequence":"first","affiliation":[{"name":"1 \u00a0Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, H\u00f4pital Albert Schweitzer, Lambar\u00e9n\u00e9, Gabon"},{"name":"2 \u00a0Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"3 \u00a0Department of Medicine I, Division of Infectious 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arti","family":"Basra","sequence":"additional","affiliation":[{"name":"1 \u00a0Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, H\u00f4pital Albert Schweitzer, Lambar\u00e9n\u00e9, Gabon"},{"name":"2 \u00a0Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"W\u00fcrbel","sequence":"additional","affiliation":[{"name":"1 \u00a0Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, H\u00f4pital Albert Schweitzer, Lambar\u00e9n\u00e9, Gabon"},{"name":"2 \u00a0Institut f\u00fcr Tropenmedizin, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Groger","sequence":"additional","affiliation":[{"name":"1 \u00a0Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, H\u00f4pital Albert Schweitzer, 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